Mammalian Lin-7 Stabilizes Polarity Protein Complexes

Mammalian Lin-7 forms a complex with several proteins, including PALS1, that have a role in polarity determination in epithelial cells. In this study we have found that loss of Lin-7 protein from the polarized epithelial cell line Madin-Darby canine kidney II by small hairpin RNA results in defects...

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Veröffentlicht in:	The Journal of biological chemistry 2006-12, Vol.281 (49), p.37738-37747
Hauptverfasser:	Straight, Samuel W., Pieczynski, Jay N., Whiteman, Eileen L., Liu, Chia-Jen, Margolis, Ben
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Cell Line Cell Polarity - physiology Dogs Drug Stability Humans Membrane Proteins - antagonists & inhibitors Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Mice Protein Structure, Tertiary Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism RNA - genetics Tight Junctions - metabolism
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