The Distribution of Fluoxetine in Human Fluids and Tissues
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that was introduced in 1986. Certain side effects of this medication—drowsiness, dizziness, abnormal vision, diarrhea, and headache—could affect pilot performance and become a factor in an aviation accident. Our laboratory has determined...
Gespeichert in:
| Veröffentlicht in: | Journal of analytical toxicology 2007-09, Vol.31 (7), p.409-414 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 414 |
|---|---|
| container_issue | 7 |
| container_start_page | 409 |
| container_title | Journal of analytical toxicology |
| container_volume | 31 |
| creator | Johnson, Robert D. Lewis, Russell J. Angier, Mike K. |
| description | Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that was introduced in 1986. Certain side effects of this medication—drowsiness, dizziness, abnormal vision, diarrhea, and headache—could affect pilot performance and become a factor in an aviation accident. Our laboratory has determined the distribution of fluoxetine and its desmethyl metabolite, norfluoxetine, in various postmortem tissues and fluids from 10 fatal aviation accident cases. When available, 11 specimen types were analyzed for each case, including blood, urine, vitreous humor, bile, liver, kidney, skeletal muscle, lung, spleen, heart muscle, and brain. Blood fluoxetine concentrations in these 10 cases ranged from 21 to 1480 ng/mL. The distribution coefficients for both fluoxetine and norfluoxetine, expressed as specimen/blood ratios, were determined. The distribution coefficients for fluoxetine were determined to be 0.9 ± 0.4 for urine, 0.10 ± 0.03 for vitreous humor, 9 ± 1 for bile, 38 ± 10 for liver, 60 ± 17 for lung, 9 ± 3 for kidney, 20 ± 5 for spleen, 2.2 ± 0.3 for muscle, 15 ± 3 for brain, and 10 ± 2 for heart. To our knowledge, this is the first report presenting the distribution of fluoxetine in humans at therapeutic concentrations. |
| doi_str_mv | 10.1093/jat/31.7.409 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68215459</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/jat/31.7.409</oup_id><sourcerecordid>68215459</sourcerecordid><originalsourceid>FETCH-LOGICAL-c586t-e1f245612875fcf773a60416a399e4b6d90907ea05189ae1a34ae8ae5fc781823</originalsourceid><addsrcrecordid>eNqF0U1P20AQBuAVagXh49Zz5UvLBYeZ_V5uiBJSCbUHgkBcVhNnLRYcO3htCf59DYnKMaeRRo_mHell7BvCGMGJ0yfqTgWOzViC22EjdFLlXIL4wkaAUufSaNhj-yk9AaC2WuyyPTSGK2vdiJ3NHkP2K6aujfO-i02dNWU2qfrmNXSxDlmss2m_pPp9Fxcpo3qRzWJKfUiH7GtJVQpHm3nAbieXs4tpfv336vfF-XVeKKu7PGDJpdLIrVFlURojSINETcK5IOd64cCBCQQKraOAJCQFS2HAxqLl4oD9XN9dtc3LkNv5ZUxFqCqqQ9Mnry1HJZXbCjmCMNbK7RCs4sptj0bHrRIfP56sYdE2KbWh9Ks2Lql98wj-vSY_1OQFeuOHmgb-fXO3ny_D4hNvehnAjw2gVFBVtlQXMX06BwKRw-CO167pV9si87Ucug6v_y21z14bYZSf3j_4P-rqRj9M7vxE_AO22LQT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19285382</pqid></control><display><type>article</type><title>The Distribution of Fluoxetine in Human Fluids and Tissues</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Johnson, Robert D. ; Lewis, Russell J. ; Angier, Mike K.</creator><creatorcontrib>Johnson, Robert D. ; Lewis, Russell J. ; Angier, Mike K.</creatorcontrib><description>Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that was introduced in 1986. Certain side effects of this medication—drowsiness, dizziness, abnormal vision, diarrhea, and headache—could affect pilot performance and become a factor in an aviation accident. Our laboratory has determined the distribution of fluoxetine and its desmethyl metabolite, norfluoxetine, in various postmortem tissues and fluids from 10 fatal aviation accident cases. When available, 11 specimen types were analyzed for each case, including blood, urine, vitreous humor, bile, liver, kidney, skeletal muscle, lung, spleen, heart muscle, and brain. Blood fluoxetine concentrations in these 10 cases ranged from 21 to 1480 ng/mL. The distribution coefficients for both fluoxetine and norfluoxetine, expressed as specimen/blood ratios, were determined. The distribution coefficients for fluoxetine were determined to be 0.9 ± 0.4 for urine, 0.10 ± 0.03 for vitreous humor, 9 ± 1 for bile, 38 ± 10 for liver, 60 ± 17 for lung, 9 ± 3 for kidney, 20 ± 5 for spleen, 2.2 ± 0.3 for muscle, 15 ± 3 for brain, and 10 ± 2 for heart. To our knowledge, this is the first report presenting the distribution of fluoxetine in humans at therapeutic concentrations.</description><identifier>ISSN: 0146-4760</identifier><identifier>EISSN: 1945-2403</identifier><identifier>DOI: 10.1093/jat/31.7.409</identifier><identifier>PMID: 17725889</identifier><identifier>CODEN: JATOD3</identifier><language>eng</language><publisher>Niles, IL: Oxford University Press</publisher><subject>Accidents, Aviation ; Analysis ; Biological and medical sciences ; Body Fluids - metabolism ; Fluoxetine - analogs & derivatives ; Fluoxetine - blood ; Fluoxetine - pharmacokinetics ; Fluoxetine - urine ; Forensic Medicine ; General pharmacology ; Humans ; Medical sciences ; Pharmacology. Drug treatments ; Serotonin Uptake Inhibitors - blood ; Serotonin Uptake Inhibitors - pharmacokinetics ; Serotonin Uptake Inhibitors - urine ; Tissue Distribution</subject><ispartof>Journal of analytical toxicology, 2007-09, Vol.31 (7), p.409-414</ispartof><rights>2007</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c586t-e1f245612875fcf773a60416a399e4b6d90907ea05189ae1a34ae8ae5fc781823</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19031120$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17725889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Robert D.</creatorcontrib><creatorcontrib>Lewis, Russell J.</creatorcontrib><creatorcontrib>Angier, Mike K.</creatorcontrib><title>The Distribution of Fluoxetine in Human Fluids and Tissues</title><title>Journal of analytical toxicology</title><addtitle>Journal of Analytical Toxicology</addtitle><addtitle>Journal of Analytical Toxicology</addtitle><description>Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that was introduced in 1986. Certain side effects of this medication—drowsiness, dizziness, abnormal vision, diarrhea, and headache—could affect pilot performance and become a factor in an aviation accident. Our laboratory has determined the distribution of fluoxetine and its desmethyl metabolite, norfluoxetine, in various postmortem tissues and fluids from 10 fatal aviation accident cases. When available, 11 specimen types were analyzed for each case, including blood, urine, vitreous humor, bile, liver, kidney, skeletal muscle, lung, spleen, heart muscle, and brain. Blood fluoxetine concentrations in these 10 cases ranged from 21 to 1480 ng/mL. The distribution coefficients for both fluoxetine and norfluoxetine, expressed as specimen/blood ratios, were determined. The distribution coefficients for fluoxetine were determined to be 0.9 ± 0.4 for urine, 0.10 ± 0.03 for vitreous humor, 9 ± 1 for bile, 38 ± 10 for liver, 60 ± 17 for lung, 9 ± 3 for kidney, 20 ± 5 for spleen, 2.2 ± 0.3 for muscle, 15 ± 3 for brain, and 10 ± 2 for heart. To our knowledge, this is the first report presenting the distribution of fluoxetine in humans at therapeutic concentrations.</description><subject>Accidents, Aviation</subject><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Body Fluids - metabolism</subject><subject>Fluoxetine - analogs & derivatives</subject><subject>Fluoxetine - blood</subject><subject>Fluoxetine - pharmacokinetics</subject><subject>Fluoxetine - urine</subject><subject>Forensic Medicine</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Serotonin Uptake Inhibitors - blood</subject><subject>Serotonin Uptake Inhibitors - pharmacokinetics</subject><subject>Serotonin Uptake Inhibitors - urine</subject><subject>Tissue Distribution</subject><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1P20AQBuAVagXh49Zz5UvLBYeZ_V5uiBJSCbUHgkBcVhNnLRYcO3htCf59DYnKMaeRRo_mHell7BvCGMGJ0yfqTgWOzViC22EjdFLlXIL4wkaAUufSaNhj-yk9AaC2WuyyPTSGK2vdiJ3NHkP2K6aujfO-i02dNWU2qfrmNXSxDlmss2m_pPp9Fxcpo3qRzWJKfUiH7GtJVQpHm3nAbieXs4tpfv336vfF-XVeKKu7PGDJpdLIrVFlURojSINETcK5IOd64cCBCQQKraOAJCQFS2HAxqLl4oD9XN9dtc3LkNv5ZUxFqCqqQ9Mnry1HJZXbCjmCMNbK7RCs4sptj0bHrRIfP56sYdE2KbWh9Ks2Lql98wj-vSY_1OQFeuOHmgb-fXO3ny_D4hNvehnAjw2gVFBVtlQXMX06BwKRw-CO167pV9si87Ucug6v_y21z14bYZSf3j_4P-rqRj9M7vxE_AO22LQT</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Johnson, Robert D.</creator><creator>Lewis, Russell J.</creator><creator>Angier, Mike K.</creator><general>Oxford University Press</general><general>Preston</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>The Distribution of Fluoxetine in Human Fluids and Tissues</title><author>Johnson, Robert D. ; Lewis, Russell J. ; Angier, Mike K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c586t-e1f245612875fcf773a60416a399e4b6d90907ea05189ae1a34ae8ae5fc781823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Accidents, Aviation</topic><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Body Fluids - metabolism</topic><topic>Fluoxetine - analogs & derivatives</topic><topic>Fluoxetine - blood</topic><topic>Fluoxetine - pharmacokinetics</topic><topic>Fluoxetine - urine</topic><topic>Forensic Medicine</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Serotonin Uptake Inhibitors - blood</topic><topic>Serotonin Uptake Inhibitors - pharmacokinetics</topic><topic>Serotonin Uptake Inhibitors - urine</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Robert D.</creatorcontrib><creatorcontrib>Lewis, Russell J.</creatorcontrib><creatorcontrib>Angier, Mike K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Robert D.</au><au>Lewis, Russell J.</au><au>Angier, Mike K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Distribution of Fluoxetine in Human Fluids and Tissues</atitle><jtitle>Journal of analytical toxicology</jtitle><stitle>Journal of Analytical Toxicology</stitle><addtitle>Journal of Analytical Toxicology</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>31</volume><issue>7</issue><spage>409</spage><epage>414</epage><pages>409-414</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><coden>JATOD3</coden><abstract>Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that was introduced in 1986. Certain side effects of this medication—drowsiness, dizziness, abnormal vision, diarrhea, and headache—could affect pilot performance and become a factor in an aviation accident. Our laboratory has determined the distribution of fluoxetine and its desmethyl metabolite, norfluoxetine, in various postmortem tissues and fluids from 10 fatal aviation accident cases. When available, 11 specimen types were analyzed for each case, including blood, urine, vitreous humor, bile, liver, kidney, skeletal muscle, lung, spleen, heart muscle, and brain. Blood fluoxetine concentrations in these 10 cases ranged from 21 to 1480 ng/mL. The distribution coefficients for both fluoxetine and norfluoxetine, expressed as specimen/blood ratios, were determined. The distribution coefficients for fluoxetine were determined to be 0.9 ± 0.4 for urine, 0.10 ± 0.03 for vitreous humor, 9 ± 1 for bile, 38 ± 10 for liver, 60 ± 17 for lung, 9 ± 3 for kidney, 20 ± 5 for spleen, 2.2 ± 0.3 for muscle, 15 ± 3 for brain, and 10 ± 2 for heart. To our knowledge, this is the first report presenting the distribution of fluoxetine in humans at therapeutic concentrations.</abstract><cop>Niles, IL</cop><pub>Oxford University Press</pub><pmid>17725889</pmid><doi>10.1093/jat/31.7.409</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-4760 |
| ispartof | Journal of analytical toxicology, 2007-09, Vol.31 (7), p.409-414 |
| issn | 0146-4760 1945-2403 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68215459 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Accidents, Aviation Analysis Biological and medical sciences Body Fluids - metabolism Fluoxetine - analogs & derivatives Fluoxetine - blood Fluoxetine - pharmacokinetics Fluoxetine - urine Forensic Medicine General pharmacology Humans Medical sciences Pharmacology. Drug treatments Serotonin Uptake Inhibitors - blood Serotonin Uptake Inhibitors - pharmacokinetics Serotonin Uptake Inhibitors - urine Tissue Distribution |
| title | The Distribution of Fluoxetine in Human Fluids and Tissues |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T16%3A10%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Distribution%20of%20Fluoxetine%20in%20Human%20Fluids%20and%20Tissues&rft.jtitle=Journal%20of%20analytical%20toxicology&rft.au=Johnson,%20Robert%20D.&rft.date=2007-09-01&rft.volume=31&rft.issue=7&rft.spage=409&rft.epage=414&rft.pages=409-414&rft.issn=0146-4760&rft.eissn=1945-2403&rft.coden=JATOD3&rft_id=info:doi/10.1093/jat/31.7.409&rft_dat=%3Cproquest_cross%3E68215459%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19285382&rft_id=info:pmid/17725889&rft_oup_id=10.1093/jat/31.7.409&rfr_iscdi=true |