Direct effect of cholesterol on insulin secretion : A novel mechanism for pancreatic β-cell dysfunction

Type 2 diabetes is often accompanied by abnormal blood lipid and lipoprotein levels, but most studies on the link between hyperlipidemia and diabetes have focused on free fatty acids (FFAs). In this study, we examined the relationship between cholesterol and insulin secretion from pancreatic beta-ce...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2007-09, Vol.56 (9), p.2328-2338
Hauptverfasser:	MINGMING HAO, HEAD, W. Steven, GUNAWARDANA, Subhadra C, HASTY, Alyssa H, PISTON, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Survival - drug effects Cholesterol - pharmacology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty Acids, Nonesterified - blood Glucokinase - metabolism Glucose - pharmacology Humans Hyperlipidemias - epidemiology Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - physiology Islets of Langerhans - physiopathology Medical sciences Mevalonic Acid - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Nitric Oxide Synthase Type I - deficiency Nitric Oxide Synthase Type I - genetics
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