Wnt signalling and the actin cytoskeleton

The tumour suppressor adenomatous polyposis coli (APC) is mutated in sporadic and familial colorectal tumours. APC binds to β -catenin, a key component of the Wnt signalling pathway, and induces its degradation. In addition to this role, there is increasing evidence for additional roles of APC, incl...

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Veröffentlicht in:	Oncogene 2006-12, Vol.25 (57), p.7538-7544
Hauptverfasser:	Akiyama, T, Kawasaki, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - chemistry Actins - metabolism Adenoma Adenomatous polyposis coli Animals Apoptosis Astrocytes - metabolism Binding sites Cdc42 protein Cell Biology Cell Membrane - metabolism Cell migration Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Cytology Cytoskeleton Cytoskeleton - metabolism Genes Genes, APC Genes, Tumor Suppressor Guanine Guanine nucleotide exchange factor Human Genetics Humans Internal Medicine IQGAP1 protein Kinesin - metabolism Malignancy Medicine Medicine & Public Health Microtubules Microtubules - metabolism Models, Biological Molecular biology Mutation Oncology Polyposis coli Rac1 protein review Signal Transduction Tumor suppressor genes Tumors Wnt protein Wnt Proteins - metabolism β-Catenin
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