The Natural Inverse Agonist Agouti-related Protein Induces Arrestin-mediated Endocytosis of Melanocortin-3 and -4 Receptors

Agouti-related protein (Agrp), one of the two naturally occurring inverse agonists known to inhibit G protein-coupled receptor activity, regulates energy expenditure by decreasing basal and blocking agonist-promoted melanocortin receptor (MCR) signaling. Here we report that, in addition to its inver...

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Veröffentlicht in:	The Journal of biological chemistry 2006-12, Vol.281 (49), p.37447-37456
Hauptverfasser:	Breit, Andreas, Wolff, Katharina, Kalwa, Hermann, Jarry, Hubertus, Büch, Thomas, Gudermann, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Agouti-Related Protein Animals Arrestins - antagonists & inhibitors Arrestins - genetics Arrestins - metabolism Base Sequence beta-Arrestins Cell Line Chlorocebus aethiops COS Cells Cyclic AMP - biosynthesis Endocytosis - physiology Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Mice Protein Binding Receptor, Melanocortin, Type 3 - antagonists & inhibitors Receptor, Melanocortin, Type 3 - genetics Receptor, Melanocortin, Type 3 - metabolism Receptor, Melanocortin, Type 4 - antagonists & inhibitors Receptor, Melanocortin, Type 4 - genetics Receptor, Melanocortin, Type 4 - metabolism Recombinant Fusion Proteins - antagonists & inhibitors Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism RNA, Small Interfering - genetics Signal Transduction Transfection
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