Identification of a mitotic recombination hotspot on chromosome III of the asexual fungus Aspergillus niger and its possible correlation with [corrected] elevated basal transcription
Genetic recombination is an important tool in strain breeding in many organisms. We studied the possibilities of mitotic recombination in strain breeding of the asexual fungus Aspergillus niger. By identifying genes that complemented mapped auxotrophic mutations, the physical map was compared to the...
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| Veröffentlicht in: | Current genetics 2007-09, Vol.52 (3-4), p.107-114 |
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| container_title | Current genetics |
| container_volume | 52 |
| creator | van de Vondervoort, Peter J I Langeveld, Sandra M J Visser, Jaap van Peij, Noël N M E Pel, Herman J van den Hondel, Cees A M J J Ram, Arthur F J |
| description | Genetic recombination is an important tool in strain breeding in many organisms. We studied the possibilities of mitotic recombination in strain breeding of the asexual fungus Aspergillus niger. By identifying genes that complemented mapped auxotrophic mutations, the physical map was compared to the genetic map of chromosome III using the genome sequence. In a program to construct a chromosome III-specific marker strain by selecting mitotic crossing-over in diploids, a mitotic recombination hotspot was identified. Analysis of the mitotic recombination hotspot revealed some physical features, elevated basal transcription and a possible correlation with purine stretches. |
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We studied the possibilities of mitotic recombination in strain breeding of the asexual fungus Aspergillus niger. By identifying genes that complemented mapped auxotrophic mutations, the physical map was compared to the genetic map of chromosome III using the genome sequence. In a program to construct a chromosome III-specific marker strain by selecting mitotic crossing-over in diploids, a mitotic recombination hotspot was identified. 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We studied the possibilities of mitotic recombination in strain breeding of the asexual fungus Aspergillus niger. By identifying genes that complemented mapped auxotrophic mutations, the physical map was compared to the genetic map of chromosome III using the genome sequence. In a program to construct a chromosome III-specific marker strain by selecting mitotic crossing-over in diploids, a mitotic recombination hotspot was identified. Analysis of the mitotic recombination hotspot revealed some physical features, elevated basal transcription and a possible correlation with purine stretches.</description><subject>Aspergillus niger - genetics</subject><subject>Chromosome Mapping</subject><subject>Chromosome Segregation</subject><subject>Chromosomes, Fungal - genetics</subject><subject>Crossing Over, Genetic</subject><subject>Diploidy</subject><subject>Genes, Fungal</subject><subject>Genetic Linkage</subject><subject>Genetic Markers</subject><subject>Microarray Analysis</subject><subject>Mitosis</subject><subject>Mutation</subject><subject>Purines - chemistry</subject><subject>Recombination, Genetic</subject><subject>Transcription, Genetic</subject><issn>0172-8083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMlOw0AQRH0AkRD4BdQnbpbGu32MIhZLkbjkhpA1HrfjQbOY6THLj_F9OAunru56XYe6CJYsKuKwZGWyCK6J3hmL4rIqroJFVORlWqTZMvitOzRe9lJwL60B2wMHLb31UoBDYXUrzckarKfRepilGJzVlqxGqOv68OQHBE74PXEF_WT2E8GaRnR7qdSsjdyjA246kJ5gtESyVQjCOofqFP8l_QCvx4vw2L0BKvzks4KW05zqHTcknBwP9E1w2XNFeHueq2D3-LDbPIfbl6d6s96GY5ZmYSIyFFledlXSsozxOOJp36a8akXMuwgZYsFYnCFLsToa1bwUUY45S-MoTlbB_Sl2dPZjQvKNliRQKW7QTtTk5YGqkhm8O4NTq7FrRic1dz_Nf9HJH3fifnU</recordid><startdate>200709</startdate><enddate>200709</enddate><creator>van de Vondervoort, Peter J I</creator><creator>Langeveld, Sandra M J</creator><creator>Visser, Jaap</creator><creator>van Peij, Noël N M E</creator><creator>Pel, Herman J</creator><creator>van den Hondel, Cees A M J J</creator><creator>Ram, Arthur F J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200709</creationdate><title>Identification of a mitotic recombination hotspot on chromosome III of the asexual fungus Aspergillus niger and its possible correlation with [corrected] elevated basal transcription</title><author>van de Vondervoort, Peter J I ; Langeveld, Sandra M J ; Visser, Jaap ; van Peij, Noël N M E ; Pel, Herman J ; van den Hondel, Cees A M J J ; Ram, Arthur F J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p545-3c5ec568d93b050a21a4fb4a9bc2ad1e0ee70025e04e9fb4a9925e716e6042123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aspergillus niger - genetics</topic><topic>Chromosome Mapping</topic><topic>Chromosome Segregation</topic><topic>Chromosomes, Fungal - genetics</topic><topic>Crossing Over, Genetic</topic><topic>Diploidy</topic><topic>Genes, Fungal</topic><topic>Genetic Linkage</topic><topic>Genetic Markers</topic><topic>Microarray Analysis</topic><topic>Mitosis</topic><topic>Mutation</topic><topic>Purines - chemistry</topic><topic>Recombination, Genetic</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van de Vondervoort, Peter J I</creatorcontrib><creatorcontrib>Langeveld, Sandra M J</creatorcontrib><creatorcontrib>Visser, Jaap</creatorcontrib><creatorcontrib>van Peij, Noël N M E</creatorcontrib><creatorcontrib>Pel, Herman J</creatorcontrib><creatorcontrib>van den Hondel, Cees A M J J</creatorcontrib><creatorcontrib>Ram, Arthur F J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Current genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van de Vondervoort, Peter J I</au><au>Langeveld, Sandra M J</au><au>Visser, Jaap</au><au>van Peij, Noël N M E</au><au>Pel, Herman J</au><au>van den Hondel, Cees A M J J</au><au>Ram, Arthur F J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of a mitotic recombination hotspot on chromosome III of the asexual fungus Aspergillus niger and its possible correlation with [corrected] elevated basal transcription</atitle><jtitle>Current genetics</jtitle><addtitle>Curr Genet</addtitle><date>2007-09</date><risdate>2007</risdate><volume>52</volume><issue>3-4</issue><spage>107</spage><epage>114</epage><pages>107-114</pages><issn>0172-8083</issn><abstract>Genetic recombination is an important tool in strain breeding in many organisms. We studied the possibilities of mitotic recombination in strain breeding of the asexual fungus Aspergillus niger. By identifying genes that complemented mapped auxotrophic mutations, the physical map was compared to the genetic map of chromosome III using the genome sequence. In a program to construct a chromosome III-specific marker strain by selecting mitotic crossing-over in diploids, a mitotic recombination hotspot was identified. Analysis of the mitotic recombination hotspot revealed some physical features, elevated basal transcription and a possible correlation with purine stretches.</abstract><cop>United States</cop><pmid>17684745</pmid><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0172-8083 |
| ispartof | Current genetics, 2007-09, Vol.52 (3-4), p.107-114 |
| issn | 0172-8083 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aspergillus niger - genetics Chromosome Mapping Chromosome Segregation Chromosomes, Fungal - genetics Crossing Over, Genetic Diploidy Genes, Fungal Genetic Linkage Genetic Markers Microarray Analysis Mitosis Mutation Purines - chemistry Recombination, Genetic Transcription, Genetic |
| title | Identification of a mitotic recombination hotspot on chromosome III of the asexual fungus Aspergillus niger and its possible correlation with [corrected] elevated basal transcription |
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