Genetically Engineered Mice in Understanding the Basis of Neonatal Lung Disease
Advances in genetic engineering have allowed the creation of animals with additional or deleted genes. New genes may be inserted in mice, specific genes inactivated or “knocked out,” and more complex animals created in which genes can be turned on or off at different times in development or in diffe...
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| Veröffentlicht in: | Seminars in perinatology 2006-12, Vol.30 (6), p.341-349 |
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| creator | Glasser, Stephan W. Nogee, Lawrence M. |
| description | Advances in genetic engineering have allowed the creation of animals with additional or deleted genes. New genes may be inserted in mice, specific genes inactivated or “knocked out,” and more complex animals created in which genes can be turned on or off at different times in development or in different tissues. These animal models allow for more detailed studies of the proteins encoded by the manipulated gene, an improved understanding of the pathophysiology of diseases resulting from the genetic alterations, and model organisms in which to study potential new therapies. Multiple mouse models involving genes important in surfactant production and regulation relevant to lung disease observed in human newborns have been created. This review will discuss the creation of such animals and illustrate their utility in understanding human disease. |
| doi_str_mv | 10.1053/j.semperi.2006.09.001 |
| format | Article |
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This review will discuss the creation of such animals and illustrate their utility in understanding human disease.</description><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>gene expression</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>knockout</subject><subject>Lung Diseases - genetics</subject><subject>Lung Diseases - metabolism</subject><subject>Lung Diseases - physiopathology</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>pulmonary surfactant</subject><subject>Pulmonary Surfactant-Associated Proteins - genetics</subject><subject>Pulmonary Surfactant-Associated Proteins - metabolism</subject><subject>Pulmonary Surfactant-Associated Proteins - physiology</subject><subject>respiratory distress syndrome</subject><subject>Respiratory Distress Syndrome, Newborn - genetics</subject><subject>Respiratory Distress Syndrome, Newborn - metabolism</subject><subject>Respiratory Distress Syndrome, Newborn - physiopathology</subject><subject>transgenic</subject><issn>0146-0005</issn><issn>1558-075X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EgvL4BJBX7BJm7DxXiDdIhW5AYmc59gRcpU6xU6T-PUGtxJLVLObcuZrD2ClCipDLi3kaabGk4FIBUKRQpwC4wyaY51UCZf6-yyaAWZEAQH7ADmOcA8isRthnB1hiJrCACZs9kKfBGd11a37nP5wnCmT5szPEnedv3lKIg_bW-Q8-fBK_1tFF3rf8hXqvB93x6Wpc3bpIOtIx22t1F-lkO4_Y2_3d681jMp09PN1cTRMjCzkkFhurRVNiq2uwuRC1bOtWytYIaoTVjaCq0mUpWgl1oYuyso0pscGsqrOyyuURO9_cXYb-a0VxUAsXDXWd9tSvoioqgZhJHMF8A5rQxxioVcvgFjqsFYL6NanmamtS_ZpUUKvR5Jg72xasmgXZv9RW3QhcbgAa3_x2FFQ0jrwh6wKZQdne_VPxAwweh0A</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Glasser, Stephan W.</creator><creator>Nogee, Lawrence M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Genetically Engineered Mice in Understanding the Basis of Neonatal Lung Disease</title><author>Glasser, Stephan W. ; Nogee, Lawrence M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-d1bda2b71fa90d52293f9f33fc2eb2dab2e88a772f3096a678dbc71b148947853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>gene expression</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>knockout</topic><topic>Lung Diseases - genetics</topic><topic>Lung Diseases - metabolism</topic><topic>Lung Diseases - physiopathology</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Mice, Transgenic</topic><topic>pulmonary surfactant</topic><topic>Pulmonary Surfactant-Associated Proteins - genetics</topic><topic>Pulmonary Surfactant-Associated Proteins - metabolism</topic><topic>Pulmonary Surfactant-Associated Proteins - physiology</topic><topic>respiratory distress syndrome</topic><topic>Respiratory Distress Syndrome, Newborn - genetics</topic><topic>Respiratory Distress Syndrome, Newborn - metabolism</topic><topic>Respiratory Distress Syndrome, Newborn - physiopathology</topic><topic>transgenic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Glasser, Stephan W.</creatorcontrib><creatorcontrib>Nogee, Lawrence M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Glasser, Stephan W.</au><au>Nogee, Lawrence M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetically Engineered Mice in Understanding the Basis of Neonatal Lung Disease</atitle><jtitle>Seminars in perinatology</jtitle><addtitle>Semin Perinatol</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>30</volume><issue>6</issue><spage>341</spage><epage>349</epage><pages>341-349</pages><issn>0146-0005</issn><eissn>1558-075X</eissn><abstract>Advances in genetic engineering have allowed the creation of animals with additional or deleted genes. 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| fulltext | fulltext |
| identifier | ISSN: 0146-0005 |
| ispartof | Seminars in perinatology, 2006-12, Vol.30 (6), p.341-349 |
| issn | 0146-0005 1558-075X |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Disease Models, Animal gene expression Humans Infant, Newborn knockout Lung Diseases - genetics Lung Diseases - metabolism Lung Diseases - physiopathology Mice Mice, Knockout Mice, Transgenic pulmonary surfactant Pulmonary Surfactant-Associated Proteins - genetics Pulmonary Surfactant-Associated Proteins - metabolism Pulmonary Surfactant-Associated Proteins - physiology respiratory distress syndrome Respiratory Distress Syndrome, Newborn - genetics Respiratory Distress Syndrome, Newborn - metabolism Respiratory Distress Syndrome, Newborn - physiopathology transgenic |
| title | Genetically Engineered Mice in Understanding the Basis of Neonatal Lung Disease |
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