Solid Carriers for Improved Solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System

The purpose of this study was to increase the solubility of glipizide (gli) by solid dispersions SDs technique with polyvinylpyrrolidone (PVP) in aqueous media. The gli-PVP solid dispersion systems was prepared by physical mixing or spray drying method, and characterized by differential scanning cal...

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Veröffentlicht in:	Drug development and industrial pharmacy 2007-08, Vol.33 (8), p.812-823
Hauptverfasser:	Mehramizi, Ali, Alijani, Behnaz, Pourfarzib, Mojgan, Dorkoosh, Farid A., Rafiee - Tehrani, Morteza
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Biological and medical sciences Calorimetry, Differential Scanning Delayed-Action Preparations differential scanning calorimetery (DSC) Drug Carriers General pharmacology glipizide Glipizide - chemistry Hydrogen-Ion Concentration Hypoglycemic Agents - chemistry Medical sciences Microscopy, Electron, Scanning Osmosis osmotic pump Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments polyvinylpyrrolidone (PVP) Povidone - chemistry solid dispersions Solubility Spectroscopy, Fourier Transform Infrared Tablets X-Ray Diffraction X-ray diffraction analysis (XRD)
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