Solid Carriers for Improved Solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System
The purpose of this study was to increase the solubility of glipizide (gli) by solid dispersions SDs technique with polyvinylpyrrolidone (PVP) in aqueous media. The gli-PVP solid dispersion systems was prepared by physical mixing or spray drying method, and characterized by differential scanning cal...
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| Veröffentlicht in: | Drug development and industrial pharmacy 2007-08, Vol.33 (8), p.812-823 |
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| container_title | Drug development and industrial pharmacy |
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| creator | Mehramizi, Ali Alijani, Behnaz Pourfarzib, Mojgan Dorkoosh, Farid A. Rafiee - Tehrani, Morteza |
| description | The purpose of this study was to increase the solubility of glipizide (gli) by solid dispersions SDs technique with polyvinylpyrrolidone (PVP) in aqueous media. The gli-PVP solid dispersion systems was prepared by physical mixing or spray drying method, and characterized by differential scanning calorimetry (DSC), X-ray powder diffraction (XRD) analysis, Fourier transformation-infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The elementary osmotic pumps (EOPs) were prepared with gli-PVP complex and the effect of the PVP percentages on the enhancing of gli dissolution rate was studied. The influences of various parameters e.g., drug- PVP ratio, level of solubility modifier, coating weight gain and diameter of drug releasing orifice on drug release profiles were also investigated. The solubility and dissolution rates of gli were significantly increased by solid dispersion using spray dried method as well as their physical mixture. The obtained results indicated that gli-PVP solid dispersion system has suitable solubility behavior in EOP tablets. |
| doi_str_mv | 10.1080/03639040601128753 |
| format | Article |
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The gli-PVP solid dispersion systems was prepared by physical mixing or spray drying method, and characterized by differential scanning calorimetry (DSC), X-ray powder diffraction (XRD) analysis, Fourier transformation-infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The elementary osmotic pumps (EOPs) were prepared with gli-PVP complex and the effect of the PVP percentages on the enhancing of gli dissolution rate was studied. The influences of various parameters e.g., drug- PVP ratio, level of solubility modifier, coating weight gain and diameter of drug releasing orifice on drug release profiles were also investigated. The solubility and dissolution rates of gli were significantly increased by solid dispersion using spray dried method as well as their physical mixture. The obtained results indicated that gli-PVP solid dispersion system has suitable solubility behavior in EOP tablets.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.1080/03639040601128753</identifier><identifier>PMID: 17729098</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Administration, Oral ; Biological and medical sciences ; Calorimetry, Differential Scanning ; Delayed-Action Preparations ; differential scanning calorimetery (DSC) ; Drug Carriers ; General pharmacology ; glipizide ; Glipizide - chemistry ; Hydrogen-Ion Concentration ; Hypoglycemic Agents - chemistry ; Medical sciences ; Microscopy, Electron, Scanning ; Osmosis ; osmotic pump ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; polyvinylpyrrolidone (PVP) ; Povidone - chemistry ; solid dispersions ; Solubility ; Spectroscopy, Fourier Transform Infrared ; Tablets ; X-Ray Diffraction ; X-ray diffraction analysis (XRD)</subject><ispartof>Drug development and industrial pharmacy, 2007-08, Vol.33 (8), p.812-823</ispartof><rights>2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2007</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-a5744385149851531e6d961c1692e0f9315da1a6156c7964346b24a647c6393a3</citedby><cites>FETCH-LOGICAL-c434t-a5744385149851531e6d961c1692e0f9315da1a6156c7964346b24a647c6393a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/03639040601128753$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/03639040601128753$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19033648$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17729098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehramizi, Ali</creatorcontrib><creatorcontrib>Alijani, Behnaz</creatorcontrib><creatorcontrib>Pourfarzib, Mojgan</creatorcontrib><creatorcontrib>Dorkoosh, Farid A.</creatorcontrib><creatorcontrib>Rafiee - Tehrani, Morteza</creatorcontrib><title>Solid Carriers for Improved Solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System</title><title>Drug development and industrial pharmacy</title><addtitle>Drug Dev Ind Pharm</addtitle><description>The purpose of this study was to increase the solubility of glipizide (gli) by solid dispersions SDs technique with polyvinylpyrrolidone (PVP) in aqueous media. The gli-PVP solid dispersion systems was prepared by physical mixing or spray drying method, and characterized by differential scanning calorimetry (DSC), X-ray powder diffraction (XRD) analysis, Fourier transformation-infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The elementary osmotic pumps (EOPs) were prepared with gli-PVP complex and the effect of the PVP percentages on the enhancing of gli dissolution rate was studied. The influences of various parameters e.g., drug- PVP ratio, level of solubility modifier, coating weight gain and diameter of drug releasing orifice on drug release profiles were also investigated. The solubility and dissolution rates of gli were significantly increased by solid dispersion using spray dried method as well as their physical mixture. The obtained results indicated that gli-PVP solid dispersion system has suitable solubility behavior in EOP tablets.</description><subject>Administration, Oral</subject><subject>Biological and medical sciences</subject><subject>Calorimetry, Differential Scanning</subject><subject>Delayed-Action Preparations</subject><subject>differential scanning calorimetery (DSC)</subject><subject>Drug Carriers</subject><subject>General pharmacology</subject><subject>glipizide</subject><subject>Glipizide - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hypoglycemic Agents - chemistry</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Osmosis</subject><subject>osmotic pump</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>polyvinylpyrrolidone (PVP)</subject><subject>Povidone - chemistry</subject><subject>solid dispersions</subject><subject>Solubility</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Tablets</subject><subject>X-Ray Diffraction</subject><subject>X-ray diffraction analysis (XRD)</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQQC0EokvhB3BBvsAt4O_EggvallKp0h4K52jWcVpXTryMk6Lw6-vVLqoQUi_2we-NPI-Qt5x95Kxhn5g00jLFDONcNLWWz8iKa8EqXRvxnKz271UB9Al5lfMdY1xYrV-SE17XwjLbrMjNdYqho2tADB4z7RPSy2GH6d53tLzN2xDDtNDU04sYduFP6DwNI93kIU3BQYwLXadxwhRjMTYIkZ7hfEPPfAz3Hhd6veTJD6_Jix5i9m-O9yn5-e38x_p7dbW5uFx_vaqckmqqQNdKyUZzZcuhJfems4Y7bqzwrLeS6w44GK6Nq60pjtkKBUbVrqSQIE_Jh8PcssKv2eepHUJ2PkYYfZpzaxrBSyxRQH4AHaac0fftDsMAuLSctfu67X91i_PuOHzeDr57NI45C_D-CEAubXqE0YX8yFkmpVF77suBC2MJPsDvhLFrJ1hiwr-SfOofn__Rbz3E6dYB-vYuzTiWwE9s8QAspqXE</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Mehramizi, Ali</creator><creator>Alijani, Behnaz</creator><creator>Pourfarzib, Mojgan</creator><creator>Dorkoosh, Farid A.</creator><creator>Rafiee - Tehrani, Morteza</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Solid Carriers for Improved Solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System</title><author>Mehramizi, Ali ; Alijani, Behnaz ; Pourfarzib, Mojgan ; Dorkoosh, Farid A. ; Rafiee - Tehrani, Morteza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-a5744385149851531e6d961c1692e0f9315da1a6156c7964346b24a647c6393a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Administration, Oral</topic><topic>Biological and medical sciences</topic><topic>Calorimetry, Differential Scanning</topic><topic>Delayed-Action Preparations</topic><topic>differential scanning calorimetery (DSC)</topic><topic>Drug Carriers</topic><topic>General pharmacology</topic><topic>glipizide</topic><topic>Glipizide - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hypoglycemic Agents - chemistry</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Osmosis</topic><topic>osmotic pump</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>polyvinylpyrrolidone (PVP)</topic><topic>Povidone - chemistry</topic><topic>solid dispersions</topic><topic>Solubility</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Tablets</topic><topic>X-Ray Diffraction</topic><topic>X-ray diffraction analysis (XRD)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehramizi, Ali</creatorcontrib><creatorcontrib>Alijani, Behnaz</creatorcontrib><creatorcontrib>Pourfarzib, Mojgan</creatorcontrib><creatorcontrib>Dorkoosh, Farid A.</creatorcontrib><creatorcontrib>Rafiee - Tehrani, Morteza</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug development and industrial pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehramizi, Ali</au><au>Alijani, Behnaz</au><au>Pourfarzib, Mojgan</au><au>Dorkoosh, Farid A.</au><au>Rafiee - Tehrani, Morteza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solid Carriers for Improved Solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System</atitle><jtitle>Drug development and industrial pharmacy</jtitle><addtitle>Drug Dev Ind Pharm</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>33</volume><issue>8</issue><spage>812</spage><epage>823</epage><pages>812-823</pages><issn>0363-9045</issn><eissn>1520-5762</eissn><abstract>The purpose of this study was to increase the solubility of glipizide (gli) by solid dispersions SDs technique with polyvinylpyrrolidone (PVP) in aqueous media. The gli-PVP solid dispersion systems was prepared by physical mixing or spray drying method, and characterized by differential scanning calorimetry (DSC), X-ray powder diffraction (XRD) analysis, Fourier transformation-infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The elementary osmotic pumps (EOPs) were prepared with gli-PVP complex and the effect of the PVP percentages on the enhancing of gli dissolution rate was studied. The influences of various parameters e.g., drug- PVP ratio, level of solubility modifier, coating weight gain and diameter of drug releasing orifice on drug release profiles were also investigated. The solubility and dissolution rates of gli were significantly increased by solid dispersion using spray dried method as well as their physical mixture. The obtained results indicated that gli-PVP solid dispersion system has suitable solubility behavior in EOP tablets.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>17729098</pmid><doi>10.1080/03639040601128753</doi><tpages>12</tpages></addata></record> |
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| subjects | Administration, Oral Biological and medical sciences Calorimetry, Differential Scanning Delayed-Action Preparations differential scanning calorimetery (DSC) Drug Carriers General pharmacology glipizide Glipizide - chemistry Hydrogen-Ion Concentration Hypoglycemic Agents - chemistry Medical sciences Microscopy, Electron, Scanning Osmosis osmotic pump Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments polyvinylpyrrolidone (PVP) Povidone - chemistry solid dispersions Solubility Spectroscopy, Fourier Transform Infrared Tablets X-Ray Diffraction X-ray diffraction analysis (XRD) |
| title | Solid Carriers for Improved Solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System |
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