Solid lipid nanoparticles (SLN) as carriers for the topical delivery of econazole nitrate: in-vitro characterization, ex-vivo and in-vivo studies

Solid lipid nanoparticles (SLN) designed for topical administration of econazole nitrate (ECN), were prepared by o/w high‐shear homogenization method using different ratios of lipid and drug (5:1 and 10:1). SLN were characterized in terms of particle size, morphology, encapsulation efficiency and cr...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2007-08, Vol.59 (8), p.1057-1064
Hauptverfasser:	Sanna, Vanna, Gavini, Elisabetta, Cossu, Massimo, Rassu, Giovanna, Giunchedi, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Adult Animals Antifungal Agents - administration & dosage Antifungal Agents - chemistry Antifungal Agents - pharmacokinetics Calorimetry, Differential Scanning Crystallization Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Carriers - pharmacokinetics Econazole - administration & dosage Econazole - chemistry Econazole - pharmacokinetics Female Humans Hydrogels - chemistry Hydrogels - pharmacokinetics Lipids - chemistry Microscopy, Electron, Scanning Nanoparticles - chemistry Particle Size Skin - drug effects Skin - metabolism Skin Absorption Swine
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