Does regional brain perfusion correlate with eating disorder symptoms in anorexia and bulimia nervosa patients?
Abstract Objective Using single photon emission computed tomography (SPECT), we sought brain perfusion correlates of eating disorder symptoms in anorexia and bulimia nervosa patients. Method We investigated 67 female eating disordered (ED) patients. Eating disorder symptoms were measured by the Eati...
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| Veröffentlicht in: | Journal of psychiatric research 2007-12, Vol.41 (12), p.1005-1011 |
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| creator | Goethals, Ingeborg Vervaet, Myriam Audenaert, Kurt Jacobs, Filip Ham, Hamphrey Van Heeringen, Cees |
| description | Abstract Objective Using single photon emission computed tomography (SPECT), we sought brain perfusion correlates of eating disorder symptoms in anorexia and bulimia nervosa patients. Method We investigated 67 female eating disordered (ED) patients. Eating disorder symptoms were measured by the Eating Disorders Inventory (EDI). Determination of brain areas in which regional perfusion co-varied with drive for thinness, bulimia, body dissatisfaction, ineffectiveness, perfectionism, interpersonal distrust, interoceptive awareness and maturity fears was done by open explorative correlation analysis using Statistical Parametrical Mapping (SPM). Results A significant positive correlation between scores on body dissatisfaction and ineffectiveness, and brain perfusion in the prefrontal and parietal cortex was demonstrated. There were no correlations between other eating disorder symptoms and brain perfusion. Conclusion Based on the finding of an association between regional brain flow and body dissatisfaction and ineffectiveness, we argue that neurobiological findings in ED patients may not only reflect emotional and behavioural factors but cognitive–evaluative features as well. |
| doi_str_mv | 10.1016/j.jpsychires.2006.09.003 |
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Method We investigated 67 female eating disordered (ED) patients. Eating disorder symptoms were measured by the Eating Disorders Inventory (EDI). Determination of brain areas in which regional perfusion co-varied with drive for thinness, bulimia, body dissatisfaction, ineffectiveness, perfectionism, interpersonal distrust, interoceptive awareness and maturity fears was done by open explorative correlation analysis using Statistical Parametrical Mapping (SPM). Results A significant positive correlation between scores on body dissatisfaction and ineffectiveness, and brain perfusion in the prefrontal and parietal cortex was demonstrated. There were no correlations between other eating disorder symptoms and brain perfusion. Conclusion Based on the finding of an association between regional brain flow and body dissatisfaction and ineffectiveness, we argue that neurobiological findings in ED patients may not only reflect emotional and behavioural factors but cognitive–evaluative features as well.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2006.09.003</identifier><identifier>PMID: 17054991</identifier><identifier>CODEN: JPYRA3</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Anorexia nervosa ; Anorexia Nervosa - diagnostic imaging ; Anorexia Nervosa - physiopathology ; Biological and medical sciences ; Brain - blood supply ; Brain - diagnostic imaging ; Bulimia ; Bulimia Nervosa - diagnostic imaging ; Bulimia Nervosa - physiopathology ; Cerebrovascular Circulation ; Correlation analysis ; Eating behavior disorders ; Eating disorders ; Female ; Humans ; Medical sciences ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Regional cerebral blood flow ; Single photon emission computed tomography ; Statistical Parametrical Mapping ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Journal of psychiatric research, 2007-12, Vol.41 (12), p.1005-1011</ispartof><rights>Elsevier Ltd</rights><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-a731ac66e3165405ba6e4888041bb33ad7a6030eee2238901636bbfa6bd342a43</citedby><cites>FETCH-LOGICAL-c457t-a731ac66e3165405ba6e4888041bb33ad7a6030eee2238901636bbfa6bd342a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S002239560600183X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19050823$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17054991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goethals, Ingeborg</creatorcontrib><creatorcontrib>Vervaet, Myriam</creatorcontrib><creatorcontrib>Audenaert, Kurt</creatorcontrib><creatorcontrib>Jacobs, Filip</creatorcontrib><creatorcontrib>Ham, Hamphrey</creatorcontrib><creatorcontrib>Van Heeringen, Cees</creatorcontrib><title>Does regional brain perfusion correlate with eating disorder symptoms in anorexia and bulimia nervosa patients?</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>Abstract Objective Using single photon emission computed tomography (SPECT), we sought brain perfusion correlates of eating disorder symptoms in anorexia and bulimia nervosa patients. Method We investigated 67 female eating disordered (ED) patients. Eating disorder symptoms were measured by the Eating Disorders Inventory (EDI). Determination of brain areas in which regional perfusion co-varied with drive for thinness, bulimia, body dissatisfaction, ineffectiveness, perfectionism, interpersonal distrust, interoceptive awareness and maturity fears was done by open explorative correlation analysis using Statistical Parametrical Mapping (SPM). Results A significant positive correlation between scores on body dissatisfaction and ineffectiveness, and brain perfusion in the prefrontal and parietal cortex was demonstrated. There were no correlations between other eating disorder symptoms and brain perfusion. Conclusion Based on the finding of an association between regional brain flow and body dissatisfaction and ineffectiveness, we argue that neurobiological findings in ED patients may not only reflect emotional and behavioural factors but cognitive–evaluative features as well.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Anorexia nervosa</subject><subject>Anorexia Nervosa - diagnostic imaging</subject><subject>Anorexia Nervosa - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Brain - blood supply</subject><subject>Brain - diagnostic imaging</subject><subject>Bulimia</subject><subject>Bulimia Nervosa - diagnostic imaging</subject><subject>Bulimia Nervosa - physiopathology</subject><subject>Cerebrovascular Circulation</subject><subject>Correlation analysis</subject><subject>Eating behavior disorders</subject><subject>Eating disorders</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Regional cerebral blood flow</subject><subject>Single photon emission computed tomography</subject><subject>Statistical Parametrical Mapping</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2L1TAUhoMoznX0L0g2ums9Sdq03SjO-AkDLlRwF9L0dCbXtqk57ej996bcCxdcucohvB_hyWGMC8gFCP1qn-9nOrg7H5FyCaBzaHIA9YDtRF01mVBV85DtAKTMVFPqC_aEaA8AlRTFY3YhKiiLphE7Ft4FJB7x1ofJDryN1k98xtivlG64CzHiYBfkv_1yx9EufrrlnacQO4ycDuO8hJF4MtkpRPzjbRo63q6DH9M8YbwPZPmcjDgt9OYpe9TbgfDZ6bxk3z-8_3b9Kbv58vHz9dubzBVltWS2UsI6rVEJXRZQtlZjUdc1FKJtlbJdZTUoQEQpVd0kJkq3bW9126lC2kJdspfH3DmGXyvSYkZPDofBThhWMrqW0JRKJmF9FLoYiCL2Zo5-tPFgBJgNttmbM2yzwTbQmAQ7WZ-fOtZ2xO5sPNFNghcngSVnhz7ayXk66xoooZZb0NVRh4nIvcdoyCVcDrvU6RbTBf8_r3n9T4gb_ORT7088IO3DGtMPkxGGpAHzdVuObTdAA4ha_VB_AXrzuZo</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Goethals, Ingeborg</creator><creator>Vervaet, Myriam</creator><creator>Audenaert, Kurt</creator><creator>Jacobs, Filip</creator><creator>Ham, Hamphrey</creator><creator>Van Heeringen, Cees</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>Does regional brain perfusion correlate with eating disorder symptoms in anorexia and bulimia nervosa patients?</title><author>Goethals, Ingeborg ; Vervaet, Myriam ; Audenaert, Kurt ; Jacobs, Filip ; Ham, Hamphrey ; Van Heeringen, Cees</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-a731ac66e3165405ba6e4888041bb33ad7a6030eee2238901636bbfa6bd342a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Anorexia nervosa</topic><topic>Anorexia Nervosa - diagnostic imaging</topic><topic>Anorexia Nervosa - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Brain - blood supply</topic><topic>Brain - diagnostic imaging</topic><topic>Bulimia</topic><topic>Bulimia Nervosa - diagnostic imaging</topic><topic>Bulimia Nervosa - physiopathology</topic><topic>Cerebrovascular Circulation</topic><topic>Correlation analysis</topic><topic>Eating behavior disorders</topic><topic>Eating disorders</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Regional cerebral blood flow</topic><topic>Single photon emission computed tomography</topic><topic>Statistical Parametrical Mapping</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goethals, Ingeborg</creatorcontrib><creatorcontrib>Vervaet, Myriam</creatorcontrib><creatorcontrib>Audenaert, Kurt</creatorcontrib><creatorcontrib>Jacobs, Filip</creatorcontrib><creatorcontrib>Ham, Hamphrey</creatorcontrib><creatorcontrib>Van Heeringen, Cees</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goethals, Ingeborg</au><au>Vervaet, Myriam</au><au>Audenaert, Kurt</au><au>Jacobs, Filip</au><au>Ham, Hamphrey</au><au>Van Heeringen, Cees</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does regional brain perfusion correlate with eating disorder symptoms in anorexia and bulimia nervosa patients?</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>41</volume><issue>12</issue><spage>1005</spage><epage>1011</epage><pages>1005-1011</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><coden>JPYRA3</coden><abstract>Abstract Objective Using single photon emission computed tomography (SPECT), we sought brain perfusion correlates of eating disorder symptoms in anorexia and bulimia nervosa patients. Method We investigated 67 female eating disordered (ED) patients. Eating disorder symptoms were measured by the Eating Disorders Inventory (EDI). Determination of brain areas in which regional perfusion co-varied with drive for thinness, bulimia, body dissatisfaction, ineffectiveness, perfectionism, interpersonal distrust, interoceptive awareness and maturity fears was done by open explorative correlation analysis using Statistical Parametrical Mapping (SPM). Results A significant positive correlation between scores on body dissatisfaction and ineffectiveness, and brain perfusion in the prefrontal and parietal cortex was demonstrated. There were no correlations between other eating disorder symptoms and brain perfusion. Conclusion Based on the finding of an association between regional brain flow and body dissatisfaction and ineffectiveness, we argue that neurobiological findings in ED patients may not only reflect emotional and behavioural factors but cognitive–evaluative features as well.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17054991</pmid><doi>10.1016/j.jpsychires.2006.09.003</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Anorexia nervosa Anorexia Nervosa - diagnostic imaging Anorexia Nervosa - physiopathology Biological and medical sciences Brain - blood supply Brain - diagnostic imaging Bulimia Bulimia Nervosa - diagnostic imaging Bulimia Nervosa - physiopathology Cerebrovascular Circulation Correlation analysis Eating behavior disorders Eating disorders Female Humans Medical sciences Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Regional cerebral blood flow Single photon emission computed tomography Statistical Parametrical Mapping Tomography, Emission-Computed, Single-Photon |
| title | Does regional brain perfusion correlate with eating disorder symptoms in anorexia and bulimia nervosa patients? |
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