Variability and memory of protein levels in human cells

Feel the noise Genetically identical cells produce variable levels of a given protein at a given time. This 'noise' in genetic expression is implicated in many important processes including cell fate determination and resistance to drugs. So far the phenomenon has been observed directly on...

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Veröffentlicht in:	Nature 2006-11, Vol.444 (7119), p.643-646
Hauptverfasser:	Sigal, Alex, Milo, Ron, Cohen, Ariel, Geva-Zatorsky, Naama, Klein, Yael, Liron, Yuvalal, Rosenfeld, Nitzan, Danon, Tamar, Perzov, Natalie, Alon, Uri
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Biodiversity Biological and medical sciences Cell Line, Tumor Cellular biology Chromosomes DNA Topoisomerases, Type I - metabolism Endopeptidases - metabolism Fluctuations Fundamental and applied biological sciences. Psychology Genotype & phenotype HMGA2 Protein - metabolism Humanities and Social Sciences Humans letter Luminescent Proteins - genetics Microorganisms Microscopy, Fluorescence Molecular and cellular biology Molecular genetics multidisciplinary Phenotypic variations Proteins Proteins - genetics Proteins - metabolism Science Standard deviation Stochastic processes Translation. Translation factors. Protein processing Ubiquitin Thiolesterase Ubiquitin-Specific Peptidase 7 Variability
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