Simultaneous determination of desloratadine and pseudoephedrine in human plasma using micro solid-phase extraction tips and aqueous normal-phase liquid chromatography/tandem mass spectrometry

Cation‐exchange micro solid‐phase extraction (SPE) tips and aqueous normal‐phase (ANP) chromatography coupled with tandem mass spectrometry were explored for the rapid, selective and sensitive quantitation of desloratadine and pseudoephedrine in human plasma. A novel micro‐SPE device was evaluated f...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2007-09, Vol.21 (18), p.3145-3155
Hauptverfasser:	Shen, Jim X., Xu, Yan, Tama, Cristina I., Merka, Eric A., Clement, Robert P., Hayes, Roger N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Chemical Analysis - methods Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Complex Mixtures - blood Ephedrine - blood Humans Loratadine - analogs & derivatives Loratadine - blood Reproducibility of Results Sensitivity and Specificity Solid Phase Microextraction - instrumentation Solid Phase Microextraction - methods Spectrometry, Mass, Electrospray Ionization - instrumentation Spectrometry, Mass, Electrospray Ionization - methods
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