The value of preoperative platelet count in the prediction of cervical involvement and poor prognostic variables in patients with endometrial carcinoma

To evaluate the relationship between preoperative platelet counts and prognostic factors extensively, among endometrial cancer patients, especially with respect to cervical involvement. One-hundred fifty-five patients with endometrial carcinoma, who underwent surgery as the initial treatment consist...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Gynecologic oncology 2006-12, Vol.103 (3), p.902-905
Hauptverfasser: Ayhan, Ali, Bozdag, Gurkan, Taskiran, Cagatay, Gultekin, Murat, Yuce, Kunter, Kucukali, Turkan
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 905
container_issue 3
container_start_page 902
container_title Gynecologic oncology
container_volume 103
creator Ayhan, Ali
Bozdag, Gurkan
Taskiran, Cagatay
Gultekin, Murat
Yuce, Kunter
Kucukali, Turkan
description To evaluate the relationship between preoperative platelet counts and prognostic factors extensively, among endometrial cancer patients, especially with respect to cervical involvement. One-hundred fifty-five patients with endometrial carcinoma, who underwent surgery as the initial treatment consisting peritoneal cytology, total abdominal hysterectomy, bilateral salpingo-oophorectomy, systematic pelvic-paraaortic lymphadenectomy, and omentectomy were retrospectively analyzed. There were no differences with respect to age, histological type (endometrioid vs. non-endometrioid), depth of myometrial invasion, peritoneal cytology, LVSI, and lymphatic metastasis. However, advanced stage (stages III and IV), poorly differentiated tumor grade (grade 3), the presence of cervical and adnexal involvements were associated with significantly higher median preoperative platelet counts. Accepting 325.000/μl platelet count as a threshold value, multivariate analysis revealed cervical involvement ( P = 0.008; OR = 1.84, 95% CI:1.17–2.89) and presence of high grade histology ( P = 0.014; OR = 2.23, 95% CI:1.18–4.23, for grade 3 disease) to be significantly associated with higher platelet count. At a cut-off value of 326.000/μl, 42.3% sensitivity and 82.8% specificity for the prediction of cervical involvement was observed under receiver operator characteristic curve method. Higher preoperative platelet counts, even in conditions with normal range (150.000–400.000/μl), may reflect poor prognostic factors such as cervical involvement and high grade among patients with endometrial carcinoma. Also, the higher platelet count should be taken into consideration for the necessity of radical hysterectomy.
doi_str_mv 10.1016/j.ygyno.2006.05.034
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68209350</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0090825806004318</els_id><sourcerecordid>68209350</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-477536b6b679aff371edc6e03364c2015bfb6a1a378b0d1d7b8ae9f3aa34e4aa3</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxi0EotvCEyAhn7glHcf5e-CAqtJWqtRLOVuOM2m9cuJgO0H7JLwus-xK3JAl-zC_75vxfIx9EpALEPX1Pj-8HGafFwB1DlUOsnzDdgK6KqvbqnvLdgAdZG1RtRfsMsY9AEgQxXt2Ieq2aNuy2bHfz6_IN-1W5H7kS0C_YNDJbsgXpxM6TNz4dU7czjwRS8hgTbJ-PgoMhs0a7ai6ebfhhETqeeCL94FY_zL7mKyhFsHq3mE8-izUgMDIf9n0ynEe_ISJ6o4bHYyd_aQ_sHejdhE_nt8r9uP77fPNffb4dPdw8-0xM7JqUlY2TSXrnk7T6XGUjcDB1AhS1qUpQFT92NdaaNm0PQxiaPpWYzdKrWWJJd1X7MvJl2b9uWJMarLRoHN6Rr9GRYuCTlZAoDyBJvgYA45qCXbS4aAEqGMeaq_-5qGOeSioFOVBqs9n-7WfcPinOQdAwNcTgPTJzWJQ0dBuDC05oElq8Pa_Df4A6QaiSw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68209350</pqid></control><display><type>article</type><title>The value of preoperative platelet count in the prediction of cervical involvement and poor prognostic variables in patients with endometrial carcinoma</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Ayhan, Ali ; Bozdag, Gurkan ; Taskiran, Cagatay ; Gultekin, Murat ; Yuce, Kunter ; Kucukali, Turkan</creator><creatorcontrib>Ayhan, Ali ; Bozdag, Gurkan ; Taskiran, Cagatay ; Gultekin, Murat ; Yuce, Kunter ; Kucukali, Turkan</creatorcontrib><description>To evaluate the relationship between preoperative platelet counts and prognostic factors extensively, among endometrial cancer patients, especially with respect to cervical involvement. One-hundred fifty-five patients with endometrial carcinoma, who underwent surgery as the initial treatment consisting peritoneal cytology, total abdominal hysterectomy, bilateral salpingo-oophorectomy, systematic pelvic-paraaortic lymphadenectomy, and omentectomy were retrospectively analyzed. There were no differences with respect to age, histological type (endometrioid vs. non-endometrioid), depth of myometrial invasion, peritoneal cytology, LVSI, and lymphatic metastasis. However, advanced stage (stages III and IV), poorly differentiated tumor grade (grade 3), the presence of cervical and adnexal involvements were associated with significantly higher median preoperative platelet counts. Accepting 325.000/μl platelet count as a threshold value, multivariate analysis revealed cervical involvement ( P = 0.008; OR = 1.84, 95% CI:1.17–2.89) and presence of high grade histology ( P = 0.014; OR = 2.23, 95% CI:1.18–4.23, for grade 3 disease) to be significantly associated with higher platelet count. At a cut-off value of 326.000/μl, 42.3% sensitivity and 82.8% specificity for the prediction of cervical involvement was observed under receiver operator characteristic curve method. Higher preoperative platelet counts, even in conditions with normal range (150.000–400.000/μl), may reflect poor prognostic factors such as cervical involvement and high grade among patients with endometrial carcinoma. Also, the higher platelet count should be taken into consideration for the necessity of radical hysterectomy.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/j.ygyno.2006.05.034</identifier><identifier>PMID: 16828847</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cervical involvement ; Endometrial carcinoma ; Endometrial Neoplasms - blood ; Endometrial Neoplasms - diagnosis ; Endometrial Neoplasms - pathology ; Endometrial Neoplasms - surgery ; Female ; Humans ; Hysterectomy ; Lymph Node Excision ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Pelvis ; Platelet Count ; Predictive Value of Tests ; Preoperative Care ; Prognosis ; ROC Curve ; Sensitivity and Specificity ; Thrombocytosis ; Uterine Cervical Neoplasms - blood ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - secondary ; Uterine Cervical Neoplasms - surgery</subject><ispartof>Gynecologic oncology, 2006-12, Vol.103 (3), p.902-905</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-477536b6b679aff371edc6e03364c2015bfb6a1a378b0d1d7b8ae9f3aa34e4aa3</citedby><cites>FETCH-LOGICAL-c357t-477536b6b679aff371edc6e03364c2015bfb6a1a378b0d1d7b8ae9f3aa34e4aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ygyno.2006.05.034$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16828847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ayhan, Ali</creatorcontrib><creatorcontrib>Bozdag, Gurkan</creatorcontrib><creatorcontrib>Taskiran, Cagatay</creatorcontrib><creatorcontrib>Gultekin, Murat</creatorcontrib><creatorcontrib>Yuce, Kunter</creatorcontrib><creatorcontrib>Kucukali, Turkan</creatorcontrib><title>The value of preoperative platelet count in the prediction of cervical involvement and poor prognostic variables in patients with endometrial carcinoma</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>To evaluate the relationship between preoperative platelet counts and prognostic factors extensively, among endometrial cancer patients, especially with respect to cervical involvement. One-hundred fifty-five patients with endometrial carcinoma, who underwent surgery as the initial treatment consisting peritoneal cytology, total abdominal hysterectomy, bilateral salpingo-oophorectomy, systematic pelvic-paraaortic lymphadenectomy, and omentectomy were retrospectively analyzed. There were no differences with respect to age, histological type (endometrioid vs. non-endometrioid), depth of myometrial invasion, peritoneal cytology, LVSI, and lymphatic metastasis. However, advanced stage (stages III and IV), poorly differentiated tumor grade (grade 3), the presence of cervical and adnexal involvements were associated with significantly higher median preoperative platelet counts. Accepting 325.000/μl platelet count as a threshold value, multivariate analysis revealed cervical involvement ( P = 0.008; OR = 1.84, 95% CI:1.17–2.89) and presence of high grade histology ( P = 0.014; OR = 2.23, 95% CI:1.18–4.23, for grade 3 disease) to be significantly associated with higher platelet count. At a cut-off value of 326.000/μl, 42.3% sensitivity and 82.8% specificity for the prediction of cervical involvement was observed under receiver operator characteristic curve method. Higher preoperative platelet counts, even in conditions with normal range (150.000–400.000/μl), may reflect poor prognostic factors such as cervical involvement and high grade among patients with endometrial carcinoma. Also, the higher platelet count should be taken into consideration for the necessity of radical hysterectomy.</description><subject>Cervical involvement</subject><subject>Endometrial carcinoma</subject><subject>Endometrial Neoplasms - blood</subject><subject>Endometrial Neoplasms - diagnosis</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrial Neoplasms - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Lymph Node Excision</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Staging</subject><subject>Pelvis</subject><subject>Platelet Count</subject><subject>Predictive Value of Tests</subject><subject>Preoperative Care</subject><subject>Prognosis</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Thrombocytosis</subject><subject>Uterine Cervical Neoplasms - blood</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - secondary</subject><subject>Uterine Cervical Neoplasms - surgery</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxi0EotvCEyAhn7glHcf5e-CAqtJWqtRLOVuOM2m9cuJgO0H7JLwus-xK3JAl-zC_75vxfIx9EpALEPX1Pj-8HGafFwB1DlUOsnzDdgK6KqvbqnvLdgAdZG1RtRfsMsY9AEgQxXt2Ieq2aNuy2bHfz6_IN-1W5H7kS0C_YNDJbsgXpxM6TNz4dU7czjwRS8hgTbJ-PgoMhs0a7ai6ebfhhETqeeCL94FY_zL7mKyhFsHq3mE8-izUgMDIf9n0ynEe_ISJ6o4bHYyd_aQ_sHejdhE_nt8r9uP77fPNffb4dPdw8-0xM7JqUlY2TSXrnk7T6XGUjcDB1AhS1qUpQFT92NdaaNm0PQxiaPpWYzdKrWWJJd1X7MvJl2b9uWJMarLRoHN6Rr9GRYuCTlZAoDyBJvgYA45qCXbS4aAEqGMeaq_-5qGOeSioFOVBqs9n-7WfcPinOQdAwNcTgPTJzWJQ0dBuDC05oElq8Pa_Df4A6QaiSw</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Ayhan, Ali</creator><creator>Bozdag, Gurkan</creator><creator>Taskiran, Cagatay</creator><creator>Gultekin, Murat</creator><creator>Yuce, Kunter</creator><creator>Kucukali, Turkan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>The value of preoperative platelet count in the prediction of cervical involvement and poor prognostic variables in patients with endometrial carcinoma</title><author>Ayhan, Ali ; Bozdag, Gurkan ; Taskiran, Cagatay ; Gultekin, Murat ; Yuce, Kunter ; Kucukali, Turkan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-477536b6b679aff371edc6e03364c2015bfb6a1a378b0d1d7b8ae9f3aa34e4aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Cervical involvement</topic><topic>Endometrial carcinoma</topic><topic>Endometrial Neoplasms - blood</topic><topic>Endometrial Neoplasms - diagnosis</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrial Neoplasms - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Lymph Node Excision</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Staging</topic><topic>Pelvis</topic><topic>Platelet Count</topic><topic>Predictive Value of Tests</topic><topic>Preoperative Care</topic><topic>Prognosis</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Thrombocytosis</topic><topic>Uterine Cervical Neoplasms - blood</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - secondary</topic><topic>Uterine Cervical Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ayhan, Ali</creatorcontrib><creatorcontrib>Bozdag, Gurkan</creatorcontrib><creatorcontrib>Taskiran, Cagatay</creatorcontrib><creatorcontrib>Gultekin, Murat</creatorcontrib><creatorcontrib>Yuce, Kunter</creatorcontrib><creatorcontrib>Kucukali, Turkan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ayhan, Ali</au><au>Bozdag, Gurkan</au><au>Taskiran, Cagatay</au><au>Gultekin, Murat</au><au>Yuce, Kunter</au><au>Kucukali, Turkan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The value of preoperative platelet count in the prediction of cervical involvement and poor prognostic variables in patients with endometrial carcinoma</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>103</volume><issue>3</issue><spage>902</spage><epage>905</epage><pages>902-905</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><abstract>To evaluate the relationship between preoperative platelet counts and prognostic factors extensively, among endometrial cancer patients, especially with respect to cervical involvement. One-hundred fifty-five patients with endometrial carcinoma, who underwent surgery as the initial treatment consisting peritoneal cytology, total abdominal hysterectomy, bilateral salpingo-oophorectomy, systematic pelvic-paraaortic lymphadenectomy, and omentectomy were retrospectively analyzed. There were no differences with respect to age, histological type (endometrioid vs. non-endometrioid), depth of myometrial invasion, peritoneal cytology, LVSI, and lymphatic metastasis. However, advanced stage (stages III and IV), poorly differentiated tumor grade (grade 3), the presence of cervical and adnexal involvements were associated with significantly higher median preoperative platelet counts. Accepting 325.000/μl platelet count as a threshold value, multivariate analysis revealed cervical involvement ( P = 0.008; OR = 1.84, 95% CI:1.17–2.89) and presence of high grade histology ( P = 0.014; OR = 2.23, 95% CI:1.18–4.23, for grade 3 disease) to be significantly associated with higher platelet count. At a cut-off value of 326.000/μl, 42.3% sensitivity and 82.8% specificity for the prediction of cervical involvement was observed under receiver operator characteristic curve method. Higher preoperative platelet counts, even in conditions with normal range (150.000–400.000/μl), may reflect poor prognostic factors such as cervical involvement and high grade among patients with endometrial carcinoma. Also, the higher platelet count should be taken into consideration for the necessity of radical hysterectomy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16828847</pmid><doi>10.1016/j.ygyno.2006.05.034</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0090-8258
ispartof Gynecologic oncology, 2006-12, Vol.103 (3), p.902-905
issn 0090-8258
1095-6859
language eng
recordid cdi_proquest_miscellaneous_68209350
source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Cervical involvement
Endometrial carcinoma
Endometrial Neoplasms - blood
Endometrial Neoplasms - diagnosis
Endometrial Neoplasms - pathology
Endometrial Neoplasms - surgery
Female
Humans
Hysterectomy
Lymph Node Excision
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Pelvis
Platelet Count
Predictive Value of Tests
Preoperative Care
Prognosis
ROC Curve
Sensitivity and Specificity
Thrombocytosis
Uterine Cervical Neoplasms - blood
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - secondary
Uterine Cervical Neoplasms - surgery
title The value of preoperative platelet count in the prediction of cervical involvement and poor prognostic variables in patients with endometrial carcinoma
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T12%3A30%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20value%20of%20preoperative%20platelet%20count%20in%20the%20prediction%20of%20cervical%20involvement%20and%20poor%20prognostic%20variables%20in%20patients%20with%20endometrial%20carcinoma&rft.jtitle=Gynecologic%20oncology&rft.au=Ayhan,%20Ali&rft.date=2006-12-01&rft.volume=103&rft.issue=3&rft.spage=902&rft.epage=905&rft.pages=902-905&rft.issn=0090-8258&rft.eissn=1095-6859&rft_id=info:doi/10.1016/j.ygyno.2006.05.034&rft_dat=%3Cproquest_cross%3E68209350%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68209350&rft_id=info:pmid/16828847&rft_els_id=S0090825806004318&rfr_iscdi=true