Exposure to marijuana during pregnancy alters neurobehavior in the early neonatal period
To assess the neurobehavior of full-term neonates of adolescent mothers exposed to marijuana during pregnancy. This prospective cross-sectional study included full-term infants within 24 to 72 hours of life born to adolescent mothers at a single center in Brazil. Data on sociodemographic and obstetr...
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| Veröffentlicht in: | The Journal of pediatrics 2006-12, Vol.149 (6), p.781-787 |
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| container_title | The Journal of pediatrics |
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| creator | de Moraes Barros, Marina Carvalho Guinsburg, Ruth de Araújo Peres, Clovis Mitsuhiro, Sandro Chalem, Elisa Laranjeira, Ronaldo Ramos |
| description | To assess the neurobehavior of full-term neonates of adolescent mothers exposed to marijuana during pregnancy.
This prospective cross-sectional study included full-term infants within 24 to 72 hours of life born to adolescent mothers at a single center in Brazil. Data on sociodemographic and obstetrical and neonatal characteristics were collected. The mothers underwent the Composite International Diagnostic Interview, and the infants were assessed with the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS). Maternal hair and neonatal meconium were analyzed. Neonates exposed in utero to tobacco, alcohol, cocaine, and/or any other drugs except marijuana were excluded.
Of 3685 infants born in the study hospital, 928 (25%) were born to adolescent mothers. Of these, 561 infants met the inclusion criteria and were studied. Marijuana exposure was detected in 26 infants (4.6%). Infants exposed (E) or not exposed (NE) to marijuana differed in the following NNNS variables: arousal (E, 4.05 ± 1.19 vs NE, 3.68 ± 0.70), regulation (E, 5.75 ± 0.62 vs NE, 6.04 ± 0.72), and excitability (E, 3.27 ± 1.40 vs NE, 2.40 ± 1.57). After controlling for confounding variables, the effect of marijuana exposure on these scores remained significant.
Marijuana exposure during pregnancy alters the neurobehavioral performance of term newborn infants of adolescent mothers. |
| doi_str_mv | 10.1016/j.jpeds.2006.08.046 |
| format | Article |
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This prospective cross-sectional study included full-term infants within 24 to 72 hours of life born to adolescent mothers at a single center in Brazil. Data on sociodemographic and obstetrical and neonatal characteristics were collected. The mothers underwent the Composite International Diagnostic Interview, and the infants were assessed with the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS). Maternal hair and neonatal meconium were analyzed. Neonates exposed in utero to tobacco, alcohol, cocaine, and/or any other drugs except marijuana were excluded.
Of 3685 infants born in the study hospital, 928 (25%) were born to adolescent mothers. Of these, 561 infants met the inclusion criteria and were studied. Marijuana exposure was detected in 26 infants (4.6%). Infants exposed (E) or not exposed (NE) to marijuana differed in the following NNNS variables: arousal (E, 4.05 ± 1.19 vs NE, 3.68 ± 0.70), regulation (E, 5.75 ± 0.62 vs NE, 6.04 ± 0.72), and excitability (E, 3.27 ± 1.40 vs NE, 2.40 ± 1.57). After controlling for confounding variables, the effect of marijuana exposure on these scores remained significant.
Marijuana exposure during pregnancy alters the neurobehavioral performance of term newborn infants of adolescent mothers.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2006.08.046</identifier><identifier>PMID: 17137892</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Biological and medical sciences ; Cross-Sectional Studies ; Female ; General aspects ; Humans ; Infant Behavior - drug effects ; Infant, Newborn ; Male ; Marijuana Smoking - adverse effects ; Medical sciences ; Nervous System - drug effects ; Nervous System - physiopathology ; Pregnancy ; Prospective Studies</subject><ispartof>The Journal of pediatrics, 2006-12, Vol.149 (6), p.781-787</ispartof><rights>2006 Mosby, Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-6f82e3927dad91b92d433a2c22d05816529816d2e0d2deaa973470c82edb26913</citedby><cites>FETCH-LOGICAL-c387t-6f82e3927dad91b92d433a2c22d05816529816d2e0d2deaa973470c82edb26913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347606007992$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18404555$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17137892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Moraes Barros, Marina Carvalho</creatorcontrib><creatorcontrib>Guinsburg, Ruth</creatorcontrib><creatorcontrib>de Araújo Peres, Clovis</creatorcontrib><creatorcontrib>Mitsuhiro, Sandro</creatorcontrib><creatorcontrib>Chalem, Elisa</creatorcontrib><creatorcontrib>Laranjeira, Ronaldo Ramos</creatorcontrib><title>Exposure to marijuana during pregnancy alters neurobehavior in the early neonatal period</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To assess the neurobehavior of full-term neonates of adolescent mothers exposed to marijuana during pregnancy.
This prospective cross-sectional study included full-term infants within 24 to 72 hours of life born to adolescent mothers at a single center in Brazil. Data on sociodemographic and obstetrical and neonatal characteristics were collected. The mothers underwent the Composite International Diagnostic Interview, and the infants were assessed with the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS). Maternal hair and neonatal meconium were analyzed. Neonates exposed in utero to tobacco, alcohol, cocaine, and/or any other drugs except marijuana were excluded.
Of 3685 infants born in the study hospital, 928 (25%) were born to adolescent mothers. Of these, 561 infants met the inclusion criteria and were studied. Marijuana exposure was detected in 26 infants (4.6%). Infants exposed (E) or not exposed (NE) to marijuana differed in the following NNNS variables: arousal (E, 4.05 ± 1.19 vs NE, 3.68 ± 0.70), regulation (E, 5.75 ± 0.62 vs NE, 6.04 ± 0.72), and excitability (E, 3.27 ± 1.40 vs NE, 2.40 ± 1.57). After controlling for confounding variables, the effect of marijuana exposure on these scores remained significant.
Marijuana exposure during pregnancy alters the neurobehavioral performance of term newborn infants of adolescent mothers.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infant Behavior - drug effects</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Marijuana Smoking - adverse effects</subject><subject>Medical sciences</subject><subject>Nervous System - drug effects</subject><subject>Nervous System - physiopathology</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhq0KVLbQX1Cp8gVuCWM7cewDB4Toh4TUC0jcLK89C46ycWoniP33mO5K3HqZOczzjmYeQr4xqBkwednX_YQ-1xxA1qBqaOQnsmKgu0oqIY7ICoDzSjSdPCFfcu4BQDcAn8kJ65jolOYr8nj7OsW8JKRzpFubQr_Y0VK_pDA-0Snh02hHt6N2mDFlOuKS4hqf7UuIiYaRzs9I0aZhV0ZxtLMd6IQpRH9Gjjd2yPj10E_Jw4_b-5tf1d2fn79vru8qJ1Q3V3KjOArNO2-9ZmvNfSOE5Y5zD61isuW6VM8RPPdore7KP-BKyK-51Eyckov93inFvwvm2WxDdjgMthy0ZCMVB82gKaDYgy7FnBNuzJRC-XhnGJh3oaY3_4Sad6EGlClCS-r7Yf2y3qL_yBwMFuD8ANjs7LBJRVfIH5xqoGnbtnBXew6LjJeAyWQXcHToQ0I3Gx_Dfw95A0qElYY</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>de Moraes Barros, Marina Carvalho</creator><creator>Guinsburg, Ruth</creator><creator>de Araújo Peres, Clovis</creator><creator>Mitsuhiro, Sandro</creator><creator>Chalem, Elisa</creator><creator>Laranjeira, Ronaldo Ramos</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Exposure to marijuana during pregnancy alters neurobehavior in the early neonatal period</title><author>de Moraes Barros, Marina Carvalho ; Guinsburg, Ruth ; de Araújo Peres, Clovis ; Mitsuhiro, Sandro ; Chalem, Elisa ; Laranjeira, Ronaldo Ramos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-6f82e3927dad91b92d433a2c22d05816529816d2e0d2deaa973470c82edb26913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infant Behavior - drug effects</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Marijuana Smoking - adverse effects</topic><topic>Medical sciences</topic><topic>Nervous System - drug effects</topic><topic>Nervous System - physiopathology</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Moraes Barros, Marina Carvalho</creatorcontrib><creatorcontrib>Guinsburg, Ruth</creatorcontrib><creatorcontrib>de Araújo Peres, Clovis</creatorcontrib><creatorcontrib>Mitsuhiro, Sandro</creatorcontrib><creatorcontrib>Chalem, Elisa</creatorcontrib><creatorcontrib>Laranjeira, Ronaldo Ramos</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Moraes Barros, Marina Carvalho</au><au>Guinsburg, Ruth</au><au>de Araújo Peres, Clovis</au><au>Mitsuhiro, Sandro</au><au>Chalem, Elisa</au><au>Laranjeira, Ronaldo Ramos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to marijuana during pregnancy alters neurobehavior in the early neonatal period</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>149</volume><issue>6</issue><spage>781</spage><epage>787</epage><pages>781-787</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>To assess the neurobehavior of full-term neonates of adolescent mothers exposed to marijuana during pregnancy.
This prospective cross-sectional study included full-term infants within 24 to 72 hours of life born to adolescent mothers at a single center in Brazil. Data on sociodemographic and obstetrical and neonatal characteristics were collected. The mothers underwent the Composite International Diagnostic Interview, and the infants were assessed with the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS). Maternal hair and neonatal meconium were analyzed. Neonates exposed in utero to tobacco, alcohol, cocaine, and/or any other drugs except marijuana were excluded.
Of 3685 infants born in the study hospital, 928 (25%) were born to adolescent mothers. Of these, 561 infants met the inclusion criteria and were studied. Marijuana exposure was detected in 26 infants (4.6%). Infants exposed (E) or not exposed (NE) to marijuana differed in the following NNNS variables: arousal (E, 4.05 ± 1.19 vs NE, 3.68 ± 0.70), regulation (E, 5.75 ± 0.62 vs NE, 6.04 ± 0.72), and excitability (E, 3.27 ± 1.40 vs NE, 2.40 ± 1.57). After controlling for confounding variables, the effect of marijuana exposure on these scores remained significant.
Marijuana exposure during pregnancy alters the neurobehavioral performance of term newborn infants of adolescent mothers.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>17137892</pmid><doi>10.1016/j.jpeds.2006.08.046</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences Cross-Sectional Studies Female General aspects Humans Infant Behavior - drug effects Infant, Newborn Male Marijuana Smoking - adverse effects Medical sciences Nervous System - drug effects Nervous System - physiopathology Pregnancy Prospective Studies |
| title | Exposure to marijuana during pregnancy alters neurobehavior in the early neonatal period |
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