High intake of palatable food predicts binge-eating independent of susceptibility to obesity: an animal model of lean vs obese binge-eating and obesity with and without binge-eating
Objective: To determine the stability of individual differences in non-nutritive 'junk' palatable food (PF) intake in rats; assess the relationship of these differences to binge-eating characteristics and susceptibility to obesity; and evaluate the practicality of using these differences t...
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| Veröffentlicht in: | International Journal of Obesity 2007-09, Vol.31 (9), p.1357-1367 |
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| container_title | International Journal of Obesity |
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| creator | Boggiano, M.M Artiga, A.I Pritchett, C.E Chandler-Laney, P.C Smith, M.L Eldridge, A.J |
| description | Objective: To determine the stability of individual differences in non-nutritive 'junk' palatable food (PF) intake in rats; assess the relationship of these differences to binge-eating characteristics and susceptibility to obesity; and evaluate the practicality of using these differences to model binge-eating and obesity. Design: Binge-eating prone (BEP) and resistant (BER) groups were identified. Differential responses to stress, hunger, macronutrient-varied PFs, a diet-induced obesity (DIO) regimen and daily vs intermittent access to a PF+chow diet, were assessed. Subjects: One hundred and twenty female Sprague-Dawley rats. Measurements: Reliability of intake patterns within rats; food intake and body weight after various challenges over acute (1, 2, 4 h), 24-h and 2-week periods. Results: Although BEP and BER rats did not differ in amount of chow consumed, BEPs consumed >50% more intermittent PF than BERs (P |
| doi_str_mv | 10.1038/sj.ijo.0803614 |
| format | Article |
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Design: Binge-eating prone (BEP) and resistant (BER) groups were identified. Differential responses to stress, hunger, macronutrient-varied PFs, a diet-induced obesity (DIO) regimen and daily vs intermittent access to a PF+chow diet, were assessed. Subjects: One hundred and twenty female Sprague-Dawley rats. Measurements: Reliability of intake patterns within rats; food intake and body weight after various challenges over acute (1, 2, 4 h), 24-h and 2-week periods. Results: Although BEP and BER rats did not differ in amount of chow consumed, BEPs consumed >50% more intermittent PF than BERs (P<0.001) and consistently so (alpha=0.86). BEPs suppressed chow but not PF intake when stressed, and ate as much when sated as when hungry. Conversely, BERs were more affected by stress and ate less PF, not chow, when stressed and were normally hyperphagic to energy deficit. BEP overeating generalized to other PFs varying in sucrose, fat and nutrition content. Half the rats in each group proved to be obesity prone after a no-choice high fat diet (DIO diet) but a continuous diet of PF+chow normalized the BEPs high drive for PF. Conclusion: Greater intermittent intake of PF predicts binge-eating independent of susceptibility to weight gain. Daily fat consumption in a nutritious source (DIO-diet; analogous to a fatty meal) promoted overeating and weight gain but limiting fat to daily non-nutritive food (PF+chow; analogous to a snack with a low fat meal), did not. The data offer an animal model of lean and obese binge-eating, and obesity with and without binge-eating that can be used to identify the unique physiology of these groups and henceforth suggest more specifically targeted treatments for binge-eating and obesity.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0803614</identifier><identifier>PMID: 17372614</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult and adolescent clinical studies ; Animal models ; Animals ; Binge eating ; binging ; Biological and medical sciences ; Body weight ; Bulimia ; Compulsive eating ; Diet ; Disease Models, Animal ; disease resistance ; Eating behavior ; Eating behavior disorders ; epidemiological studies ; Epidemiology ; etiology ; Feeding. Feeding behavior ; Female ; Food ; food intake ; food quality ; Food Supply ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Health aspects ; Health Promotion and Disease Prevention ; human behavior ; Hunger ; Hunger - physiology ; Internal Medicine ; Junk food ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Miscellaneous ; Motivation ; nutritive value ; Obesity ; Obesity - etiology ; original-article ; palatability ; Physiology ; prediction ; psychological stress ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Public Health ; Rats ; Rats, Sprague-Dawley ; Stress, Psychological - complications ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; weight gain</subject><ispartof>International Journal of Obesity, 2007-09, Vol.31 (9), p.1357-1367</ispartof><rights>Springer Nature Limited 2007</rights><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c574t-6622dc010717ef9e73c696e7119f05ec2e3da5cb8ee4cefaa6eb99fb65a3107b3</citedby><cites>FETCH-LOGICAL-c574t-6622dc010717ef9e73c696e7119f05ec2e3da5cb8ee4cefaa6eb99fb65a3107b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ijo.0803614$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ijo.0803614$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19018645$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17372614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boggiano, M.M</creatorcontrib><creatorcontrib>Artiga, A.I</creatorcontrib><creatorcontrib>Pritchett, C.E</creatorcontrib><creatorcontrib>Chandler-Laney, P.C</creatorcontrib><creatorcontrib>Smith, M.L</creatorcontrib><creatorcontrib>Eldridge, A.J</creatorcontrib><title>High intake of palatable food predicts binge-eating independent of susceptibility to obesity: an animal model of lean vs obese binge-eating and obesity with and without binge-eating</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Objective: To determine the stability of individual differences in non-nutritive 'junk' palatable food (PF) intake in rats; assess the relationship of these differences to binge-eating characteristics and susceptibility to obesity; and evaluate the practicality of using these differences to model binge-eating and obesity. Design: Binge-eating prone (BEP) and resistant (BER) groups were identified. Differential responses to stress, hunger, macronutrient-varied PFs, a diet-induced obesity (DIO) regimen and daily vs intermittent access to a PF+chow diet, were assessed. Subjects: One hundred and twenty female Sprague-Dawley rats. Measurements: Reliability of intake patterns within rats; food intake and body weight after various challenges over acute (1, 2, 4 h), 24-h and 2-week periods. Results: Although BEP and BER rats did not differ in amount of chow consumed, BEPs consumed >50% more intermittent PF than BERs (P<0.001) and consistently so (alpha=0.86). BEPs suppressed chow but not PF intake when stressed, and ate as much when sated as when hungry. Conversely, BERs were more affected by stress and ate less PF, not chow, when stressed and were normally hyperphagic to energy deficit. BEP overeating generalized to other PFs varying in sucrose, fat and nutrition content. Half the rats in each group proved to be obesity prone after a no-choice high fat diet (DIO diet) but a continuous diet of PF+chow normalized the BEPs high drive for PF. Conclusion: Greater intermittent intake of PF predicts binge-eating independent of susceptibility to weight gain. Daily fat consumption in a nutritious source (DIO-diet; analogous to a fatty meal) promoted overeating and weight gain but limiting fat to daily non-nutritive food (PF+chow; analogous to a snack with a low fat meal), did not. The data offer an animal model of lean and obese binge-eating, and obesity with and without binge-eating that can be used to identify the unique physiology of these groups and henceforth suggest more specifically targeted treatments for binge-eating and obesity.</description><subject>Adult and adolescent clinical studies</subject><subject>Animal models</subject><subject>Animals</subject><subject>Binge eating</subject><subject>binging</subject><subject>Biological and medical sciences</subject><subject>Body weight</subject><subject>Bulimia</subject><subject>Compulsive eating</subject><subject>Diet</subject><subject>Disease Models, Animal</subject><subject>disease resistance</subject><subject>Eating behavior</subject><subject>Eating behavior disorders</subject><subject>epidemiological studies</subject><subject>Epidemiology</subject><subject>etiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Food</subject><subject>food intake</subject><subject>food quality</subject><subject>Food Supply</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>human behavior</subject><subject>Hunger</subject><subject>Hunger - physiology</subject><subject>Internal Medicine</subject><subject>Junk food</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Miscellaneous</subject><subject>Motivation</subject><subject>nutritive value</subject><subject>Obesity</subject><subject>Obesity - etiology</subject><subject>original-article</subject><subject>palatability</subject><subject>Physiology</subject><subject>prediction</subject><subject>psychological stress</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Feeding behavior</topic><topic>Female</topic><topic>Food</topic><topic>food intake</topic><topic>food quality</topic><topic>Food Supply</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>Health aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>human behavior</topic><topic>Hunger</topic><topic>Hunger - physiology</topic><topic>Internal Medicine</topic><topic>Junk food</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Miscellaneous</topic><topic>Motivation</topic><topic>nutritive value</topic><topic>Obesity</topic><topic>Obesity - etiology</topic><topic>original-article</topic><topic>palatability</topic><topic>Physiology</topic><topic>prediction</topic><topic>psychological stress</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. 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Design: Binge-eating prone (BEP) and resistant (BER) groups were identified. Differential responses to stress, hunger, macronutrient-varied PFs, a diet-induced obesity (DIO) regimen and daily vs intermittent access to a PF+chow diet, were assessed. Subjects: One hundred and twenty female Sprague-Dawley rats. Measurements: Reliability of intake patterns within rats; food intake and body weight after various challenges over acute (1, 2, 4 h), 24-h and 2-week periods. Results: Although BEP and BER rats did not differ in amount of chow consumed, BEPs consumed >50% more intermittent PF than BERs (P<0.001) and consistently so (alpha=0.86). BEPs suppressed chow but not PF intake when stressed, and ate as much when sated as when hungry. Conversely, BERs were more affected by stress and ate less PF, not chow, when stressed and were normally hyperphagic to energy deficit. BEP overeating generalized to other PFs varying in sucrose, fat and nutrition content. Half the rats in each group proved to be obesity prone after a no-choice high fat diet (DIO diet) but a continuous diet of PF+chow normalized the BEPs high drive for PF. Conclusion: Greater intermittent intake of PF predicts binge-eating independent of susceptibility to weight gain. Daily fat consumption in a nutritious source (DIO-diet; analogous to a fatty meal) promoted overeating and weight gain but limiting fat to daily non-nutritive food (PF+chow; analogous to a snack with a low fat meal), did not. The data offer an animal model of lean and obese binge-eating, and obesity with and without binge-eating that can be used to identify the unique physiology of these groups and henceforth suggest more specifically targeted treatments for binge-eating and obesity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>17372614</pmid><doi>10.1038/sj.ijo.0803614</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2007-09, Vol.31 (9), p.1357-1367 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68208880 |
| source | MEDLINE; Nature Journals Online; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Adult and adolescent clinical studies Animal models Animals Binge eating binging Biological and medical sciences Body weight Bulimia Compulsive eating Diet Disease Models, Animal disease resistance Eating behavior Eating behavior disorders epidemiological studies Epidemiology etiology Feeding. Feeding behavior Female Food food intake food quality Food Supply Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Health aspects Health Promotion and Disease Prevention human behavior Hunger Hunger - physiology Internal Medicine Junk food Medical sciences Medicine Medicine & Public Health Metabolic Diseases Miscellaneous Motivation nutritive value Obesity Obesity - etiology original-article palatability Physiology prediction psychological stress Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Public Health Rats Rats, Sprague-Dawley Stress, Psychological - complications Vertebrates: anatomy and physiology, studies on body, several organs or systems weight gain |
| title | High intake of palatable food predicts binge-eating independent of susceptibility to obesity: an animal model of lean vs obese binge-eating and obesity with and without binge-eating |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T22%3A28%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%20intake%20of%20palatable%20food%20predicts%20binge-eating%20independent%20of%20susceptibility%20to%20obesity:%20an%20animal%20model%20of%20lean%20vs%20obese%20binge-eating%20and%20obesity%20with%20and%20without%20binge-eating&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Boggiano,%20M.M&rft.date=2007-09-01&rft.volume=31&rft.issue=9&rft.spage=1357&rft.epage=1367&rft.pages=1357-1367&rft.issn=0307-0565&rft.eissn=1476-5497&rft.coden=IJOBDP&rft_id=info:doi/10.1038/sj.ijo.0803614&rft_dat=%3Cgale_proqu%3EA188792723%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219273457&rft_id=info:pmid/17372614&rft_galeid=A188792723&rfr_iscdi=true |