Constitutive activation of the ERK-MAPK pathway in the suprachiasmatic nuclei inhibits circadian resetting

Circadian entrainment involves photic stimulation of the suprachiasmatic molecular oscillator, including activation of the ERK/MAP kinase, which is phosphorylated endogenously during the day and in response to light during the night. We aimed to disrupt the diurnal cycle of ERK phosphorylation by in...

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Veröffentlicht in:	FEBS letters 2006-12, Vol.580 (28), p.6665-6668
Hauptverfasser:	Hainich, Ernesto C., Pizzio, Gastón A., Golombek, Diego A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Circadian Circadian Rhythm - physiology Cricetinae Enzyme Activation ERK Extracellular Signal-Regulated MAP Kinases - metabolism Green Fluorescent Proteins - metabolism Male MAP Kinase Mesocricetus - physiology Mitogen-Activated Protein Kinases - metabolism Motor Activity - physiology Suprachiasmatic Nucleus - enzymology Suprachiasmatic Nucleus - physiology Suprachiasmtaic Transfection
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