Combined effects of moderately elevated blood glucose and locally produced TGF-beta1 on glomerular morphology and renal collagen production

There is a correlation between renal graft rejection and blood glucose (BG) levels. Furthermore, diabetic patients may develop non-diabetic renal diseases, which in some circumstances progress rapidly. Since transforming growth factor-beta1 (TGF-beta) levels are elevated in many renal diseases, the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2007-09, Vol.22 (9), p.2485-2496
Hauptverfasser:	Krag, Søren, Nyengaard, Jens R, Wogensen, Lise
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Body Weight - drug effects Collagen - biosynthesis Collagen - genetics Extracellular Matrix - drug effects Extracellular Matrix - metabolism Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation - drug effects Glomerular Basement Membrane - drug effects Glomerular Basement Membrane - ultrastructure Glomerular Mesangium - drug effects Glomerular Mesangium - enzymology Immunohistochemistry Kidney Glomerulus - cytology Kidney Glomerulus - drug effects Kidney Glomerulus - enzymology Male Mice Mice, Inbred C57BL Peptide Hydrolases - genetics Phosphoproteins - metabolism Protease Inhibitors - pharmacology Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!