5 -(3 -Cyclopentyl -2 -thioxo -2,3 -dihydro -1H -benzimidazol -5 -yl )-1-methyl -1H-pyrrole -2 -carbonitrile : A novel, highly potent, selective, and orally active non-steroidal progesterone receptor agonist

We have recently discovered 5-(3-cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (14) as a potent, selective, and orally active non-steroidal progesterone receptor (PR) agonist. Compound 14 and its analog 13 possessed sub-nanomolar in vitro potency (EC(50) 0...

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