High-Septal Pacing Reduces Ventricular Electrical Remodeling and Proarrhythmia in Chronic Atrioventricular Block Dogs
High-Septal Pacing Reduces Ventricular Electric Remodeling and Proarrhythmia in Chronic Atrioventricular Block Dogs Stephan K. G. Winckels, Morten B. Thomsen, Peter Oosterhoff, Avram Oros, Jet D. M. Beekman, Nico J. M. Attevelt, Leo Kretzers, Marc A. Vos The importance of the ventricular activation...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2007-08, Vol.50 (9), p.906-913 |
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| creator | Winckels, Stephan K.G., MD Thomsen, Morten B., PhD Oosterhoff, Peter, MSc Oros, Avram, MD Beekman, Jet D.M Attevelt, Nico J.M Kretzers, Leo, MSc Vos, Marc A., PhD |
| description | High-Septal Pacing Reduces Ventricular Electric Remodeling and Proarrhythmia in Chronic Atrioventricular Block Dogs Stephan K. G. Winckels, Morten B. Thomsen, Peter Oosterhoff, Avram Oros, Jet D. M. Beekman, Nico J. M. Attevelt, Leo Kretzers, Marc A. Vos The importance of the ventricular activation sequence on the magnitude of ventricular remodeling is investigated in the dog model of chronic atrioventricular block. For this purpose, atrioventricular block dogs that were paced from the high interventricular septum were compared to dogs with uncontrolled idioventricular rhythm. After 4 weeks of similar bradycardia, electrical remodeling and proarrhythmic response to dofetilide were less in the high-septal pacing group, suggesting that the pattern of ventricular activation does play a larger role in electric remodeling than previously assumed. |
| doi_str_mv | 10.1016/j.jacc.2007.05.019 |
| format | Article |
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G. Winckels, Morten B. Thomsen, Peter Oosterhoff, Avram Oros, Jet D. M. Beekman, Nico J. M. Attevelt, Leo Kretzers, Marc A. Vos The importance of the ventricular activation sequence on the magnitude of ventricular remodeling is investigated in the dog model of chronic atrioventricular block. For this purpose, atrioventricular block dogs that were paced from the high interventricular septum were compared to dogs with uncontrolled idioventricular rhythm. After 4 weeks of similar bradycardia, electrical remodeling and proarrhythmic response to dofetilide were less in the high-septal pacing group, suggesting that the pattern of ventricular activation does play a larger role in electric remodeling than previously assumed.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2007.05.019</identifier><identifier>PMID: 17719479</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Action Potentials ; Animals ; Arrhythmias, Cardiac - prevention & control ; Biological and medical sciences ; Bradycardia - physiopathology ; Cardiac arrhythmia ; Cardiac dysrhythmias ; Cardiac Pacing, Artificial - methods ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Disease Models, Animal ; Dogs ; Electrocardiography ; Electrophysiologic Techniques, Cardiac ; Experiments ; Fixed rates ; Heart ; Heart Block - physiopathology ; Heart Block - therapy ; Heart Conduction System - physiopathology ; Heart rate ; Heart Ventricles - innervation ; Heart Ventricles - physiopathology ; Internal Medicine ; Medical sciences ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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G. Winckels, Morten B. Thomsen, Peter Oosterhoff, Avram Oros, Jet D. M. Beekman, Nico J. M. Attevelt, Leo Kretzers, Marc A. Vos The importance of the ventricular activation sequence on the magnitude of ventricular remodeling is investigated in the dog model of chronic atrioventricular block. For this purpose, atrioventricular block dogs that were paced from the high interventricular septum were compared to dogs with uncontrolled idioventricular rhythm. After 4 weeks of similar bradycardia, electrical remodeling and proarrhythmic response to dofetilide were less in the high-septal pacing group, suggesting that the pattern of ventricular activation does play a larger role in electric remodeling than previously assumed.</description><subject>Action Potentials</subject><subject>Animals</subject><subject>Arrhythmias, Cardiac - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Bradycardia - physiopathology</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiac Pacing, Artificial - methods</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Electrocardiography</subject><subject>Electrophysiologic Techniques, Cardiac</subject><subject>Experiments</subject><subject>Fixed rates</subject><subject>Heart</subject><subject>Heart Block - physiopathology</subject><subject>Heart Block - therapy</subject><subject>Heart Conduction System - physiopathology</subject><subject>Heart rate</subject><subject>Heart Ventricles - innervation</subject><subject>Heart Ventricles - physiopathology</subject><subject>Internal Medicine</subject><subject>Medical sciences</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Vascular system</topic><topic>Cardiovascular</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Electrocardiography</topic><topic>Electrophysiologic Techniques, Cardiac</topic><topic>Experiments</topic><topic>Fixed rates</topic><topic>Heart</topic><topic>Heart Block - physiopathology</topic><topic>Heart Block - therapy</topic><topic>Heart Conduction System - physiopathology</topic><topic>Heart rate</topic><topic>Heart Ventricles - innervation</topic><topic>Heart Ventricles - physiopathology</topic><topic>Internal Medicine</topic><topic>Medical sciences</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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G. Winckels, Morten B. Thomsen, Peter Oosterhoff, Avram Oros, Jet D. M. Beekman, Nico J. M. Attevelt, Leo Kretzers, Marc A. Vos The importance of the ventricular activation sequence on the magnitude of ventricular remodeling is investigated in the dog model of chronic atrioventricular block. For this purpose, atrioventricular block dogs that were paced from the high interventricular septum were compared to dogs with uncontrolled idioventricular rhythm. After 4 weeks of similar bradycardia, electrical remodeling and proarrhythmic response to dofetilide were less in the high-septal pacing group, suggesting that the pattern of ventricular activation does play a larger role in electric remodeling than previously assumed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17719479</pmid><doi>10.1016/j.jacc.2007.05.019</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Action Potentials Animals Arrhythmias, Cardiac - prevention & control Biological and medical sciences Bradycardia - physiopathology Cardiac arrhythmia Cardiac dysrhythmias Cardiac Pacing, Artificial - methods Cardiology Cardiology. Vascular system Cardiovascular Disease Models, Animal Dogs Electrocardiography Electrophysiologic Techniques, Cardiac Experiments Fixed rates Heart Heart Block - physiopathology Heart Block - therapy Heart Conduction System - physiopathology Heart rate Heart Ventricles - innervation Heart Ventricles - physiopathology Internal Medicine Medical sciences Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Sinuses Thoracic surgery Ventricular Remodeling - physiology |
| title | High-Septal Pacing Reduces Ventricular Electrical Remodeling and Proarrhythmia in Chronic Atrioventricular Block Dogs |
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