ErbB receptor regulation by dexamethasone in mouse type II epithelial cells

Glucocorticoids stimulate foetal surfactant synthesis. Therefore, they are used in impending pre-term birth. One mechanism of action on surfactant synthesis is through the induction of neuregulin (NRG) secretion by foetal lung fibroblasts. The direct effects on signalling pathways, and specifically...

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Veröffentlicht in:	The European respiratory journal 2006-12, Vol.28 (6), p.1117-1123
Hauptverfasser:	Dammann, C. E. L, Nassimi, N, Liu, W, Nielsen, H. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Biological and medical sciences Blotting, Western Cells, Cultured Culture Media, Conditioned - pharmacology Dexamethasone - pharmacology Dimerization Epithelial Cells - drug effects Epithelial Cells - metabolism Female Fibroblasts - cytology Fibroblasts - metabolism Immunoprecipitation Lung - embryology Lung - metabolism Medical sciences Mice Neuregulins - pharmacology Phosphorylation Pneumology Pregnancy Pulmonary Surfactants - metabolism Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - metabolism Receptor, ErbB-4 Signal Transduction
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