Differential antiviral effect of PEG-interferon-alpha-2b on HIV and HCV in the treatment of HIV/HCV co-infected patients

The major antiviral effect of interferon (IFN)-alpha on hepatitis C virus (HCV) is blocking of virion production from infected cells. We now investigate the previously unknown mechanism of action of IFN-alpha against HIV. HIV kinetics in parallel to HCV kinetics and IFN pharmacokinetics during pegyl...

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Veröffentlicht in:	AIDS (London) 2007-09, Vol.21 (14), p.1855-1865
Hauptverfasser:	Neumann, Au, Polis, Ma, Rozenberg, L, Jackson, Jo, Reitano, Kn, McLaughlin, M, Koratich, C, Dewar, Rl, Masur, H, Haagmans, Bl, Kottilil, Shyam
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV Antiviral Agents - blood Antiviral Agents - pharmacokinetics Antiviral Agents - therapeutic use Female Hepacivirus - drug effects Hepatitis C - complications Hepatitis C - drug therapy Hepatitis C - virology Hepatitis C virus HIV Infections - complications HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects Human immunodeficiency virus Humans Interferon-alpha - blood Interferon-alpha - pharmacokinetics Interferon-alpha - therapeutic use Male Middle Aged Models, Biological Pilot Projects Polyethylene Glycols Prospective Studies Recombinant Proteins Ribavirin - therapeutic use RNA, Viral - analysis Viral Load Virus Replication - drug effects
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