Impact of Salmonella Typhimurium DT104 virulence factors invC and sseD on the onset, clinical course, colonization patterns and immune response of porcine salmonellosis

The present study was conducted to study the impact of the virulence factors invC and sseD of the two type III secretion systems of Salmonella enterica serovar Typhimurium ( S. Typhimurium) on the pathogenesis of the porcine S. Typhimurium DT104 infection. For this purpose, two S. Typhimurium mutant...

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Veröffentlicht in:	Veterinary microbiology 2007-10, Vol.124 (3), p.274-285
Hauptverfasser:	Brumme, Steffi, Arnold, Thorsten, Sigmarsson, Haukur, Lehmann, Jörg, Scholz, Holger C., Hardt, Wolf-Dietrich, Hensel, Andreas, Truyen, Uwe, Roesler, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation bacterial colonization Bacterial diseases Bacterial diseases of the digestive system and abdomen Bacterial Proteins - genetics Bacterial Proteins - physiology Bacteriology Biological and medical sciences Cytokines Cytokines - analysis Cytokines - biosynthesis Cytokines - genetics disease course disease models ELISA Enzyme-Linked Immunosorbent Assay - methods Enzyme-Linked Immunosorbent Assay - veterinary Feces - microbiology food pathogens Fundamental and applied biological sciences. Psychology gene expression Gene Expression Regulation, Bacterial Glyceraldehyde-3-Phosphate Dehydrogenases - genetics Human bacterial diseases Immune response Immunity, Cellular Infectious diseases invC Male Medical sciences Membrane Proteins - genetics messenger RNA microbial genetics Microbiology Miscellaneous molecular genetics mutants Mutation pathogenesis Pig Polymerase Chain Reaction - methods Polymerase Chain Reaction - veterinary Proton-Translocating ATPases - genetics Proton-Translocating ATPases - physiology Random Allocation Real-time PCR Salmonella enterica Salmonella enterica subsp. enterica serovar Typhimurium Salmonella Infections, Animal - immunology Salmonella Infections, Animal - microbiology Salmonella Typhimurium Salmonella typhimurium - genetics Salmonella typhimurium - immunology Salmonella typhimurium - pathogenicity Salmonellosis signs and symptoms (animals and humans) sseD strains Swine swine diseases Swine Diseases - immunology Swine Diseases - microbiology Type III secretion system virulence Virulence Factors - genetics Virulence Factors - physiology
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