Epoxyeicosatrienoic Acid Inhibition Alters Renal Hemodynamics During Pregnancy

In this study we examined the expression of cytochrome P450 (CYP) 2C and CYP2J Isoforms in renal proximal tubules and microvessels isolated from rats at different stages of pregnancy. We also selectively inhibited epoxyeicosatrienoic acid (EET) production by the administration of N-methanesulfonyl-6...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2006-12, Vol.231 (11), p.1744-1752
Hauptverfasser:	Huang, Hui, Chang, Hsin-Hsin, Xu, Yue, Reddy, D. Sudarshan, Du, Juan, Zhou, Yiqiang, Dong, Zheng, Falck, John R., Wang, Mong-Heng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acids - pharmacology Cytochrome P-450 Enzyme System - metabolism Epoxy Compounds - pharmacology Female Kidney - drug effects Kidney - physiology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - enzymology Microcirculation - drug effects Microcirculation - physiology Oxygenases - metabolism Pregnancy Pregnancy, Animal - drug effects Pregnancy, Animal - physiology Rats Rats, Sprague-Dawley Renal Circulation - drug effects Renal Circulation - physiology
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