Mutant tumor necrosis factor receptor associated with tumor necrosis factor receptor–associated periodic syndrome is altered antigenically and is retained within patients' leukocytes

Objective To investigate the effect of mutations in tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) in TNFR‐associated periodic syndrome (TRAPS) on the binding of anti‐TNFRSF1A monoclonal antibodies (mAb), and to investigate the subcellular distribution of mutant versus wild‐type (WT...

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Veröffentlicht in:	Arthritis and rheumatism 2007-08, Vol.56 (8), p.2765-2773
Hauptverfasser:	Todd, Ian, Radford, Paul M., Daffa, Noura, Bainbridge, Susan E., Powell, Richard J., Tighe, Patrick J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibody Diversity - genetics Antibody Diversity - immunology Binding Sites - genetics Binding Sites - immunology Biological and medical sciences Cell Line Diseases of the osteoarticular system Errors of metabolism Familial Mediterranean Fever - genetics Familial Mediterranean Fever - immunology Humans Inflammatory joint diseases Malformations and congenital and or hereditary diseases involving bones. Joint deformations Medical sciences Metabolic diseases Miscellaneous hereditary metabolic disorders Mutation Neutrophils - immunology Neutrophils - metabolism Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type I - immunology Receptors, Tumor Necrosis Factor, Type I - metabolism Transfection
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