Intelligent biosynthetic nanobiomaterials for hyperthermic combination chemotherapy and thermal drug targeting of HSP90 inhibitor geldanamycin
An intelligent biosynthetic nanobiomaterial (IBN) platform was explored for drug delivery applications for hyperthermic combination chemotherapy and thermal drug targeting. Geldanamycin (GA), a heat shock protein 90 inhibitor, was conjugated to novel thermosensitive poly(K) 8-poly(VPGXG) 60 block co...
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| Veröffentlicht in: | Journal of controlled release 2007-09, Vol.122 (1), p.16-23 |
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| creator | Bae, Younsoo Buresh, Rita A. Williamson, Tracy P. Chen, Tze-Haw Howard Furgeson, Darin Y. |
| description | An intelligent biosynthetic nanobiomaterial (IBN) platform was explored for drug delivery applications for hyperthermic combination chemotherapy and thermal drug targeting. Geldanamycin (GA), a heat shock protein 90 inhibitor, was conjugated to novel thermosensitive poly(K)
8-poly(VPGXG)
60 block copolymers [K
8-ELP(1-60)] with guest residues as valine, alanine and glycine in a 5:2:3 ratio at the ‘X’ position. The conjugates were completely soluble in PBS and showed a characteristic thermosensitive inverse phase transition. [K
8-ELP(1-60)]-GA conjugate nanoparticles showed a size ranging from 50 to 200 nm depending upon temperature. Relevant to systemic drug delivery
in vivo, these IBNs stably disperse in aqueous solution. Cytotoxicity assays have shown that the IBN from [K
8-ELP(1-60)]-GA conjugates exhibits effective hyperthermic combination chemotherapy with facile heat modulation. |
| doi_str_mv | 10.1016/j.jconrel.2007.06.005 |
| format | Article |
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8-poly(VPGXG)
60 block copolymers [K
8-ELP(1-60)] with guest residues as valine, alanine and glycine in a 5:2:3 ratio at the ‘X’ position. The conjugates were completely soluble in PBS and showed a characteristic thermosensitive inverse phase transition. [K
8-ELP(1-60)]-GA conjugate nanoparticles showed a size ranging from 50 to 200 nm depending upon temperature. Relevant to systemic drug delivery
in vivo, these IBNs stably disperse in aqueous solution. Cytotoxicity assays have shown that the IBN from [K
8-ELP(1-60)]-GA conjugates exhibits effective hyperthermic combination chemotherapy with facile heat modulation.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2007.06.005</identifier><identifier>PMID: 17651857</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject><![CDATA[Antibiotics, Antineoplastic - administration & dosage ; Antibiotics, Antineoplastic - chemistry ; Benzoquinones - administration & dosage ; Benzoquinones - chemistry ; Biological and medical sciences ; Breast Neoplasms - drug therapy ; Breast Neoplasms - therapy ; Cell Line, Tumor ; Combined Modality Therapy ; DNA, Recombinant - chemistry ; Drug Delivery Systems ; Geldanamycin ; General pharmacology ; Heat shock protein 90 ; HSP90 Heat-Shock Proteins - antagonists & inhibitors ; Humans ; Hyperthermia ; Hyperthermia, Induced - methods ; Intelligent biosynthetic nanobiomaterial (IBN) ; Lactams, Macrocyclic - administration & dosage ; Lactams, Macrocyclic - chemistry ; Medical sciences ; Nanocomposites - administration & dosage ; Nanocomposites - chemistry ; Peptides - administration & dosage ; Peptides - chemistry ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Recombinant block copolymer ; Recombinant Proteins - administration & dosage ; Recombinant Proteins - chemistry ; Thermal drug targeting]]></subject><ispartof>Journal of controlled release, 2007-09, Vol.122 (1), p.16-23</ispartof><rights>2007 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-8dab5e3f133a7bcedde2ed11ab02ffe5b6d26729f9110d2e65d4cc76028945463</citedby><cites>FETCH-LOGICAL-c424t-8dab5e3f133a7bcedde2ed11ab02ffe5b6d26729f9110d2e65d4cc76028945463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jconrel.2007.06.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19055953$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17651857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bae, Younsoo</creatorcontrib><creatorcontrib>Buresh, Rita A.</creatorcontrib><creatorcontrib>Williamson, Tracy P.</creatorcontrib><creatorcontrib>Chen, Tze-Haw Howard</creatorcontrib><creatorcontrib>Furgeson, Darin Y.</creatorcontrib><title>Intelligent biosynthetic nanobiomaterials for hyperthermic combination chemotherapy and thermal drug targeting of HSP90 inhibitor geldanamycin</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>An intelligent biosynthetic nanobiomaterial (IBN) platform was explored for drug delivery applications for hyperthermic combination chemotherapy and thermal drug targeting. Geldanamycin (GA), a heat shock protein 90 inhibitor, was conjugated to novel thermosensitive poly(K)
8-poly(VPGXG)
60 block copolymers [K
8-ELP(1-60)] with guest residues as valine, alanine and glycine in a 5:2:3 ratio at the ‘X’ position. The conjugates were completely soluble in PBS and showed a characteristic thermosensitive inverse phase transition. [K
8-ELP(1-60)]-GA conjugate nanoparticles showed a size ranging from 50 to 200 nm depending upon temperature. Relevant to systemic drug delivery
in vivo, these IBNs stably disperse in aqueous solution. Cytotoxicity assays have shown that the IBN from [K
8-ELP(1-60)]-GA conjugates exhibits effective hyperthermic combination chemotherapy with facile heat modulation.</description><subject>Antibiotics, Antineoplastic - administration & dosage</subject><subject>Antibiotics, Antineoplastic - chemistry</subject><subject>Benzoquinones - administration & dosage</subject><subject>Benzoquinones - chemistry</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - therapy</subject><subject>Cell Line, Tumor</subject><subject>Combined Modality Therapy</subject><subject>DNA, Recombinant - chemistry</subject><subject>Drug Delivery Systems</subject><subject>Geldanamycin</subject><subject>General pharmacology</subject><subject>Heat shock protein 90</subject><subject>HSP90 Heat-Shock Proteins - antagonists & inhibitors</subject><subject>Humans</subject><subject>Hyperthermia</subject><subject>Hyperthermia, Induced - methods</subject><subject>Intelligent biosynthetic nanobiomaterial (IBN)</subject><subject>Lactams, Macrocyclic - administration & dosage</subject><subject>Lactams, Macrocyclic - chemistry</subject><subject>Medical sciences</subject><subject>Nanocomposites - administration & dosage</subject><subject>Nanocomposites - chemistry</subject><subject>Peptides - administration & dosage</subject><subject>Peptides - chemistry</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Recombinant block copolymer</subject><subject>Recombinant Proteins - administration & dosage</subject><subject>Recombinant Proteins - chemistry</subject><subject>Thermal drug targeting</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdGK1DAUhoMo7uzoIyi50bvWJG3S9kpk0d2FBQX1OqTJaSdDm4xJZqEv4TObOoW93KtA8uU_h_9D6B0lJSVUfDqWR-1dgKlkhDQlESUh_AXa0bapirrr-Eu0y1xbVIJ3V-g6xiPJRFU3r9EVbQSnLW926O-9SzBNdgSXcG99XFw6QLIaO-V8vphVgmDVFPHgAz4sJwgZCHMmtJ9761Sy3mF9gNmvD-q0YOUM_g-pCZtwHnFSYcyhbsR-wHc_f3QEW3ewvU05c4TJKKfmRVv3Br0a8ix4u5179Pvb1183d8XD99v7my8Pha5ZnYrWqJ5DNdCqUk2vwRhgYChVPWHDALwXhomGdUNHKTEMBDe11o0grO1qXotqjz5eck_B_zlDTHK2UecilAN_jlK0uVXeVs-CjJKKEr4m8guog48xwCBPwc4qLJISuRqTR7kZk6sxSYRcfezR-23AuZ_BPP3aFGXgwwaoqNU0BOW0jU9cRzjv-Lrp5wsHubdHC0FGbcHlcmwAnaTx9plV_gHvwrtl</recordid><startdate>20070911</startdate><enddate>20070911</enddate><creator>Bae, Younsoo</creator><creator>Buresh, Rita A.</creator><creator>Williamson, Tracy P.</creator><creator>Chen, Tze-Haw Howard</creator><creator>Furgeson, Darin Y.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070911</creationdate><title>Intelligent biosynthetic nanobiomaterials for hyperthermic combination chemotherapy and thermal drug targeting of HSP90 inhibitor geldanamycin</title><author>Bae, Younsoo ; Buresh, Rita A. ; Williamson, Tracy P. ; Chen, Tze-Haw Howard ; Furgeson, Darin Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-8dab5e3f133a7bcedde2ed11ab02ffe5b6d26729f9110d2e65d4cc76028945463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Antibiotics, Antineoplastic - administration & dosage</topic><topic>Antibiotics, Antineoplastic - chemistry</topic><topic>Benzoquinones - administration & dosage</topic><topic>Benzoquinones - chemistry</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - therapy</topic><topic>Cell Line, Tumor</topic><topic>Combined Modality Therapy</topic><topic>DNA, Recombinant - chemistry</topic><topic>Drug Delivery Systems</topic><topic>Geldanamycin</topic><topic>General pharmacology</topic><topic>Heat shock protein 90</topic><topic>HSP90 Heat-Shock Proteins - antagonists & inhibitors</topic><topic>Humans</topic><topic>Hyperthermia</topic><topic>Hyperthermia, Induced - methods</topic><topic>Intelligent biosynthetic nanobiomaterial (IBN)</topic><topic>Lactams, Macrocyclic - administration & dosage</topic><topic>Lactams, Macrocyclic - chemistry</topic><topic>Medical sciences</topic><topic>Nanocomposites - administration & dosage</topic><topic>Nanocomposites - chemistry</topic><topic>Peptides - administration & dosage</topic><topic>Peptides - chemistry</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Recombinant block copolymer</topic><topic>Recombinant Proteins - administration & dosage</topic><topic>Recombinant Proteins - chemistry</topic><topic>Thermal drug targeting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bae, Younsoo</creatorcontrib><creatorcontrib>Buresh, Rita A.</creatorcontrib><creatorcontrib>Williamson, Tracy P.</creatorcontrib><creatorcontrib>Chen, Tze-Haw Howard</creatorcontrib><creatorcontrib>Furgeson, Darin Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bae, Younsoo</au><au>Buresh, Rita A.</au><au>Williamson, Tracy P.</au><au>Chen, Tze-Haw Howard</au><au>Furgeson, Darin Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intelligent biosynthetic nanobiomaterials for hyperthermic combination chemotherapy and thermal drug targeting of HSP90 inhibitor geldanamycin</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2007-09-11</date><risdate>2007</risdate><volume>122</volume><issue>1</issue><spage>16</spage><epage>23</epage><pages>16-23</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>An intelligent biosynthetic nanobiomaterial (IBN) platform was explored for drug delivery applications for hyperthermic combination chemotherapy and thermal drug targeting. Geldanamycin (GA), a heat shock protein 90 inhibitor, was conjugated to novel thermosensitive poly(K)
8-poly(VPGXG)
60 block copolymers [K
8-ELP(1-60)] with guest residues as valine, alanine and glycine in a 5:2:3 ratio at the ‘X’ position. The conjugates were completely soluble in PBS and showed a characteristic thermosensitive inverse phase transition. [K
8-ELP(1-60)]-GA conjugate nanoparticles showed a size ranging from 50 to 200 nm depending upon temperature. Relevant to systemic drug delivery
in vivo, these IBNs stably disperse in aqueous solution. Cytotoxicity assays have shown that the IBN from [K
8-ELP(1-60)]-GA conjugates exhibits effective hyperthermic combination chemotherapy with facile heat modulation.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17651857</pmid><doi>10.1016/j.jconrel.2007.06.005</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of controlled release, 2007-09, Vol.122 (1), p.16-23 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - chemistry Benzoquinones - administration & dosage Benzoquinones - chemistry Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - therapy Cell Line, Tumor Combined Modality Therapy DNA, Recombinant - chemistry Drug Delivery Systems Geldanamycin General pharmacology Heat shock protein 90 HSP90 Heat-Shock Proteins - antagonists & inhibitors Humans Hyperthermia Hyperthermia, Induced - methods Intelligent biosynthetic nanobiomaterial (IBN) Lactams, Macrocyclic - administration & dosage Lactams, Macrocyclic - chemistry Medical sciences Nanocomposites - administration & dosage Nanocomposites - chemistry Peptides - administration & dosage Peptides - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Recombinant block copolymer Recombinant Proteins - administration & dosage Recombinant Proteins - chemistry Thermal drug targeting |
| title | Intelligent biosynthetic nanobiomaterials for hyperthermic combination chemotherapy and thermal drug targeting of HSP90 inhibitor geldanamycin |
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