Association of HLA DQ B1 and HLA DR B1 alleles with goitrous juvenile autoimmune hypothyroidism--a case control study
The present study was designed to analyze the distribution of HLA DQ B1* and DR B1* in patients with goitrous juvenile autoimmune hypothyroidism from Hyderabad, India. Analysis indicated an increase in the frequencies of HLA DQ B1* 03 allele (P < 0.000) and HLA DR B1* 04 (P < 0.05) alleles in...
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| Veröffentlicht in: | Journal of clinical immunology 2007-09, Vol.27 (5), p.486-489 |
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| container_title | Journal of clinical immunology |
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| creator | Rekha, P L Valluri, Vijayalakshmi Rakh, Shilpa S Pantula, Vinod Ishaq, M |
| description | The present study was designed to analyze the distribution of HLA DQ B1* and DR B1* in patients with goitrous juvenile autoimmune hypothyroidism from Hyderabad, India. Analysis indicated an increase in the frequencies of HLA DQ B1* 03 allele (P < 0.000) and HLA DR B1* 04 (P < 0.05) alleles in this group of patients when compared to the controls, whereas the frequency of DQB1* 05 was found to be decreased in patients' group compared to the controls (p < 0.01). To conclude, we report a positive correlation between DQ B1* 03 and DR B1* 04 and goitrous juvenile autoimmune hypothyroidism, whereas DQB1* 05 is observed to be negatively correlated with this thyroid dysfunction. Since the disease-susceptible HLA class II alleles appear to differ in various ethnic groups for some autoimmune diseases, the observed association from Indian series of patients holds significance. |
| doi_str_mv | 10.1007/s10875-007-9102-2 |
| format | Article |
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Analysis indicated an increase in the frequencies of HLA DQ B1* 03 allele (P < 0.000) and HLA DR B1* 04 (P < 0.05) alleles in this group of patients when compared to the controls, whereas the frequency of DQB1* 05 was found to be decreased in patients' group compared to the controls (p < 0.01). To conclude, we report a positive correlation between DQ B1* 03 and DR B1* 04 and goitrous juvenile autoimmune hypothyroidism, whereas DQB1* 05 is observed to be negatively correlated with this thyroid dysfunction. 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| subjects | Adolescent Alleles Case-Control Studies Female Genetic Predisposition to Disease Graves Disease - genetics Graves Disease - immunology HLA-DQ Antigens - genetics HLA-DQ beta-Chains HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Hypothyroidism - genetics Hypothyroidism - immunology Male |
| title | Association of HLA DQ B1 and HLA DR B1 alleles with goitrous juvenile autoimmune hypothyroidism--a case control study |
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