Living with p53, Dying of p53

The p53 tumor suppressor protein acts as a major defense against cancer. Among its most distinctive features is the ability to elicit both apoptotic death and cell cycle arrest. In this issue of Cell, Das et al. (2007) and Tanaka et al. (2007) provide new insights into the mechanisms that dictate th...

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Veröffentlicht in:	Cell 2007-08, Vol.130 (4), p.597-600
Hauptverfasser:	Aylon, Yael, Oren, Moshe
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Apoptosis - physiology Cell Cycle - genetics Cell Cycle - physiology Cell Death - genetics Cell Death - physiology DNA Damage DNA-Binding Proteins Gene Expression Regulation, Neoplastic Models, Biological Neoplasms - genetics Protein Binding Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - physiology
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Beschreibung
Zusammenfassung:	The p53 tumor suppressor protein acts as a major defense against cancer. Among its most distinctive features is the ability to elicit both apoptotic death and cell cycle arrest. In this issue of Cell, Das et al. (2007) and Tanaka et al. (2007) provide new insights into the mechanisms that dictate the life and death decisions of p53.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2007.08.005