gain-of-function screen for genes that influence axon guidance identifies the NF-kappaB protein dorsal and reveals a requirement for the kinase pelle in Drosophila photoreceptor axon targeting

To identify novel regulators of nervous system development, we used the GAL4-UAS misexpression system in Drosophila to screen for genes that influence axon guidance in developing embryos. We mobilized the Gene Search (GS) P element and identified 42 lines with insertions in unique loci, including le...

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Veröffentlicht in:	Genetics (Austin) 2007-08, Vol.176 (4), p.2247-2263
Hauptverfasser:	Mindorff, E.N, O'Keefe, D.D, Labbe, A, Yang, J.P, Ou, Y, Yoshikawa, S, van Meyel, D.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals axon targeting axons Axons - metabolism Axons - ultrastructure Base Sequence DNA Primers - genetics Drosophila melanogaster Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Female genes Genes, Insect insect development Male Motor Neurons - cytology Motor Neurons - metabolism mutants Mutation NF-kappa B - genetics NF-kappa B - metabolism nuclear factor kappaB Nuclear Proteins - genetics Nuclear Proteins - metabolism Pelle kinase Phenotype Phosphoproteins - genetics Phosphoproteins - metabolism Photoreceptor Cells, Invertebrate - embryology Photoreceptor Cells, Invertebrate - metabolism photoreceptors protein kinases Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Signal Transduction - genetics transcription factors Transcription Factors - genetics Transcription Factors - metabolism
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