Endocrine regulation of ageing

Key Points Mutations in single genes can increase the lifespans of lower metazoan organisms (worms and flies) and mammals. Many of these mutations affect genes that are involved in endocrine signalling pathways. Attenuation of signalling through the insulin/insulin-like growth factor-1 (IGF1) pathwa...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2007-09, Vol.8 (9), p.681-691
Hauptverfasser:	Russell, Steven J., Kahn, C. Ronald
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - physiology Animals Biochemistry Biomedical and Life Sciences Body fat Cancer Research Causes of Cell Biology Cellular signal transduction Developmental Biology Diabetes Endocrine System - physiology Food Genes Genetic aspects Glucuronidase - genetics Glucuronidase - pharmacology Health aspects Hormones Humans Insulin Insulin - physiology Kinases Life expectancy Life Sciences Life span Longevity - physiology Mortality Mutation Phosphorylation Physiological aspects Prevention Proteins review-article Signal Transduction Stem Cells Worms
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