Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of a clinical cohort
Background Symptoms of memory loss are a common complaint within the general population and a frequent reason for seeking medical advice. However, the clinical relevance of these symptoms to future development of neurodegenerative disease is uncertain. The aim of this study is to characterise a coho...
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| Veröffentlicht in: | International journal of geriatric psychiatry 2006-12, Vol.21 (12), p.1206-1212 |
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| container_title | International journal of geriatric psychiatry |
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| creator | Archer, H. A. MacFarlane, F. Price, S. Moore, E. K. Pepple, T. Cutler, D. Frost, C. Fox, N. C. Rossor, M. N. |
| description | Background
Symptoms of memory loss are a common complaint within the general population and a frequent reason for seeking medical advice. However, the clinical relevance of these symptoms to future development of neurodegenerative disease is uncertain. The aim of this study is to characterise a cohort of individuals with symptoms of memory loss and varying memory impairment, who will be followed longitudinally with serial neuropsychology and neuroimaging to evaluate the clinical relevance of symptoms of memory loss.
Method
Fifty‐eight subjects with symptoms of memory loss were recruited from the National Hospital for Neurology and Neurosurgery. All subjects underwent clinical assessment, APOE4 genotyping, neuroimaging and neuropsychological tests.
Results
Those with mild cognitive impairment (MCI) had an increased prevalence of the APOE4 allele, impaired performance on tests of memory, measures of IQ and naming compared to controls. Baseline brain volumes were decreased and ventricular size increased. Those with symptoms of memory loss but no cognitive impairment (SNCI) performed significantly worse on tests of memory than the control group.
Conclusions
The MCI represent a group with multiple risk factors for progression to AD. The SNCI group may represent a heterogeneous group with some individuals in the early stages of AD whilst others' memory complaints are more likely linked to anxiety or personality traits. Copyright © 2006 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/gps.1644 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68198402</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21153018</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4454-83e4ea83273e3442d54a1479abdc9c0800176c7fd272e423baf9ed255d2804153</originalsourceid><addsrcrecordid>eNqF0V1rFDEUBuAgFrtWwV8gQVB6MzVfkw_vpNq1sFRBreBNyGYyNXUymSYz6vx7s-5gRRCvQnIeziHnBeARRicYIfL8asgnmDN2B6wwUqrCmPO7YIWkrCtOKDoE93O-RqjUsLwHDjFXQnAhV-DmVYR5DsMYQ4axhcGFmGbow2B8Cq4foY0puTzEvoFjLLer3o_-m_uDvIAG2hRzhtnZ0cfedDCPUzPvGpZS53tvy5uNX2IaH4CD1nTZPVzOI_Dx7PWH0zfV5u36_PTlprKM1ayS1DFnJCWCOsoYaWpmMBPKbBurLJIIYcGtaBsiiGOEbk2rXEPquiESMVzTI_Bs33dI8WZyedTBZ-u6zvQuTllziZVkiPwXEly6ISwLfPIXvI5TKr8thqAaU45pQcd79GsjybV6SD6YNGuM9C4sXcLSu7AKfbz0m7bBNbdwSaeApwswuSywTaa3Pt86SZmq6c5Ve_fdd27-50C9fvd-Gbx4n0f347c36avmgopaf7pY680lwZ8vL5QW9CftKbnY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220513613</pqid></control><display><type>article</type><title>Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of a clinical cohort</title><source>MEDLINE</source><source>Wiley Online Library (Online service)</source><creator>Archer, H. A. ; MacFarlane, F. ; Price, S. ; Moore, E. K. ; Pepple, T. ; Cutler, D. ; Frost, C. ; Fox, N. C. ; Rossor, M. N.</creator><creatorcontrib>Archer, H. A. ; MacFarlane, F. ; Price, S. ; Moore, E. K. ; Pepple, T. ; Cutler, D. ; Frost, C. ; Fox, N. C. ; Rossor, M. N.</creatorcontrib><description>Background
Symptoms of memory loss are a common complaint within the general population and a frequent reason for seeking medical advice. However, the clinical relevance of these symptoms to future development of neurodegenerative disease is uncertain. The aim of this study is to characterise a cohort of individuals with symptoms of memory loss and varying memory impairment, who will be followed longitudinally with serial neuropsychology and neuroimaging to evaluate the clinical relevance of symptoms of memory loss.
Method
Fifty‐eight subjects with symptoms of memory loss were recruited from the National Hospital for Neurology and Neurosurgery. All subjects underwent clinical assessment, APOE4 genotyping, neuroimaging and neuropsychological tests.
Results
Those with mild cognitive impairment (MCI) had an increased prevalence of the APOE4 allele, impaired performance on tests of memory, measures of IQ and naming compared to controls. Baseline brain volumes were decreased and ventricular size increased. Those with symptoms of memory loss but no cognitive impairment (SNCI) performed significantly worse on tests of memory than the control group.
Conclusions
The MCI represent a group with multiple risk factors for progression to AD. The SNCI group may represent a heterogeneous group with some individuals in the early stages of AD whilst others' memory complaints are more likely linked to anxiety or personality traits. Copyright © 2006 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.1644</identifier><identifier>PMID: 16977678</identifier><identifier>CODEN: IJGPES</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Aged ; Alzheimer Disease - diagnosis ; Alzheimer Disease - pathology ; Alzheimer Disease - psychology ; Alzheimer's disease ; Apolipoprotein E4 - genetics ; Biological and medical sciences ; Brain - pathology ; clinical ; Cognition Disorders - diagnosis ; Cognition Disorders - pathology ; Cognition Disorders - psychology ; Cross-Sectional Studies ; Disease Progression ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Genetics ; Genotype ; Geriatric Assessment ; Geriatric psychiatry ; Geriatric psychology ; Geriatrics ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Memory ; Memory Disorders - etiology ; Memory Disorders - pathology ; memory loss ; Middle Aged ; mild cognitive impairment ; Miscellaneous ; Neuropsychological Tests ; Neuropsychology ; Prognosis ; Psychiatric Status Rating Scales ; Psychoanalysis ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; symptoms</subject><ispartof>International journal of geriatric psychiatry, 2006-12, Vol.21 (12), p.1206-1212</ispartof><rights>Copyright © 2006 John Wiley & Sons, Ltd.</rights><rights>2007 INIST-CNRS</rights><rights>Copyright John Wiley and Sons, Limited Dec 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4454-83e4ea83273e3442d54a1479abdc9c0800176c7fd272e423baf9ed255d2804153</citedby><cites>FETCH-LOGICAL-c4454-83e4ea83273e3442d54a1479abdc9c0800176c7fd272e423baf9ed255d2804153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.1644$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.1644$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18349538$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16977678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Archer, H. A.</creatorcontrib><creatorcontrib>MacFarlane, F.</creatorcontrib><creatorcontrib>Price, S.</creatorcontrib><creatorcontrib>Moore, E. K.</creatorcontrib><creatorcontrib>Pepple, T.</creatorcontrib><creatorcontrib>Cutler, D.</creatorcontrib><creatorcontrib>Frost, C.</creatorcontrib><creatorcontrib>Fox, N. C.</creatorcontrib><creatorcontrib>Rossor, M. N.</creatorcontrib><title>Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of a clinical cohort</title><title>International journal of geriatric psychiatry</title><addtitle>Int. J. Geriat. Psychiatry</addtitle><description>Background
Symptoms of memory loss are a common complaint within the general population and a frequent reason for seeking medical advice. However, the clinical relevance of these symptoms to future development of neurodegenerative disease is uncertain. The aim of this study is to characterise a cohort of individuals with symptoms of memory loss and varying memory impairment, who will be followed longitudinally with serial neuropsychology and neuroimaging to evaluate the clinical relevance of symptoms of memory loss.
Method
Fifty‐eight subjects with symptoms of memory loss were recruited from the National Hospital for Neurology and Neurosurgery. All subjects underwent clinical assessment, APOE4 genotyping, neuroimaging and neuropsychological tests.
Results
Those with mild cognitive impairment (MCI) had an increased prevalence of the APOE4 allele, impaired performance on tests of memory, measures of IQ and naming compared to controls. Baseline brain volumes were decreased and ventricular size increased. Those with symptoms of memory loss but no cognitive impairment (SNCI) performed significantly worse on tests of memory than the control group.
Conclusions
The MCI represent a group with multiple risk factors for progression to AD. The SNCI group may represent a heterogeneous group with some individuals in the early stages of AD whilst others' memory complaints are more likely linked to anxiety or personality traits. Copyright © 2006 John Wiley & Sons, Ltd.</description><subject>Aged</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease</subject><subject>Apolipoprotein E4 - genetics</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>clinical</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - pathology</subject><subject>Cognition Disorders - psychology</subject><subject>Cross-Sectional Studies</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Geriatric Assessment</subject><subject>Geriatric psychiatry</subject><subject>Geriatric psychology</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Memory Disorders - etiology</subject><subject>Memory Disorders - pathology</subject><subject>memory loss</subject><subject>Middle Aged</subject><subject>mild cognitive impairment</subject><subject>Miscellaneous</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>Prognosis</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychoanalysis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>symptoms</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V1rFDEUBuAgFrtWwV8gQVB6MzVfkw_vpNq1sFRBreBNyGYyNXUymSYz6vx7s-5gRRCvQnIeziHnBeARRicYIfL8asgnmDN2B6wwUqrCmPO7YIWkrCtOKDoE93O-RqjUsLwHDjFXQnAhV-DmVYR5DsMYQ4axhcGFmGbow2B8Cq4foY0puTzEvoFjLLer3o_-m_uDvIAG2hRzhtnZ0cfedDCPUzPvGpZS53tvy5uNX2IaH4CD1nTZPVzOI_Dx7PWH0zfV5u36_PTlprKM1ayS1DFnJCWCOsoYaWpmMBPKbBurLJIIYcGtaBsiiGOEbk2rXEPquiESMVzTI_Bs33dI8WZyedTBZ-u6zvQuTllziZVkiPwXEly6ISwLfPIXvI5TKr8thqAaU45pQcd79GsjybV6SD6YNGuM9C4sXcLSu7AKfbz0m7bBNbdwSaeApwswuSywTaa3Pt86SZmq6c5Ve_fdd27-50C9fvd-Gbx4n0f347c36avmgopaf7pY680lwZ8vL5QW9CftKbnY</recordid><startdate>200612</startdate><enddate>200612</enddate><creator>Archer, H. A.</creator><creator>MacFarlane, F.</creator><creator>Price, S.</creator><creator>Moore, E. K.</creator><creator>Pepple, T.</creator><creator>Cutler, D.</creator><creator>Frost, C.</creator><creator>Fox, N. C.</creator><creator>Rossor, M. N.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200612</creationdate><title>Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of a clinical cohort</title><author>Archer, H. A. ; MacFarlane, F. ; Price, S. ; Moore, E. K. ; Pepple, T. ; Cutler, D. ; Frost, C. ; Fox, N. C. ; Rossor, M. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4454-83e4ea83273e3442d54a1479abdc9c0800176c7fd272e423baf9ed255d2804153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - psychology</topic><topic>Alzheimer's disease</topic><topic>Apolipoprotein E4 - genetics</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>clinical</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - pathology</topic><topic>Cognition Disorders - psychology</topic><topic>Cross-Sectional Studies</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Geriatric Assessment</topic><topic>Geriatric psychiatry</topic><topic>Geriatric psychology</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Memory Disorders - etiology</topic><topic>Memory Disorders - pathology</topic><topic>memory loss</topic><topic>Middle Aged</topic><topic>mild cognitive impairment</topic><topic>Miscellaneous</topic><topic>Neuropsychological Tests</topic><topic>Neuropsychology</topic><topic>Prognosis</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychoanalysis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>symptoms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Archer, H. A.</creatorcontrib><creatorcontrib>MacFarlane, F.</creatorcontrib><creatorcontrib>Price, S.</creatorcontrib><creatorcontrib>Moore, E. K.</creatorcontrib><creatorcontrib>Pepple, T.</creatorcontrib><creatorcontrib>Cutler, D.</creatorcontrib><creatorcontrib>Frost, C.</creatorcontrib><creatorcontrib>Fox, N. C.</creatorcontrib><creatorcontrib>Rossor, M. N.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Archer, H. A.</au><au>MacFarlane, F.</au><au>Price, S.</au><au>Moore, E. K.</au><au>Pepple, T.</au><au>Cutler, D.</au><au>Frost, C.</au><au>Fox, N. C.</au><au>Rossor, M. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of a clinical cohort</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int. J. Geriat. Psychiatry</addtitle><date>2006-12</date><risdate>2006</risdate><volume>21</volume><issue>12</issue><spage>1206</spage><epage>1212</epage><pages>1206-1212</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><coden>IJGPES</coden><abstract>Background
Symptoms of memory loss are a common complaint within the general population and a frequent reason for seeking medical advice. However, the clinical relevance of these symptoms to future development of neurodegenerative disease is uncertain. The aim of this study is to characterise a cohort of individuals with symptoms of memory loss and varying memory impairment, who will be followed longitudinally with serial neuropsychology and neuroimaging to evaluate the clinical relevance of symptoms of memory loss.
Method
Fifty‐eight subjects with symptoms of memory loss were recruited from the National Hospital for Neurology and Neurosurgery. All subjects underwent clinical assessment, APOE4 genotyping, neuroimaging and neuropsychological tests.
Results
Those with mild cognitive impairment (MCI) had an increased prevalence of the APOE4 allele, impaired performance on tests of memory, measures of IQ and naming compared to controls. Baseline brain volumes were decreased and ventricular size increased. Those with symptoms of memory loss but no cognitive impairment (SNCI) performed significantly worse on tests of memory than the control group.
Conclusions
The MCI represent a group with multiple risk factors for progression to AD. The SNCI group may represent a heterogeneous group with some individuals in the early stages of AD whilst others' memory complaints are more likely linked to anxiety or personality traits. Copyright © 2006 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>16977678</pmid><doi>10.1002/gps.1644</doi><tpages>7</tpages></addata></record> |
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| ispartof | International journal of geriatric psychiatry, 2006-12, Vol.21 (12), p.1206-1212 |
| issn | 0885-6230 1099-1166 |
| language | eng |
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| subjects | Aged Alzheimer Disease - diagnosis Alzheimer Disease - pathology Alzheimer Disease - psychology Alzheimer's disease Apolipoprotein E4 - genetics Biological and medical sciences Brain - pathology clinical Cognition Disorders - diagnosis Cognition Disorders - pathology Cognition Disorders - psychology Cross-Sectional Studies Disease Progression Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Genetics Genotype Geriatric Assessment Geriatric psychiatry Geriatric psychology Geriatrics Humans Magnetic Resonance Imaging - methods Male Medical sciences Memory Memory Disorders - etiology Memory Disorders - pathology memory loss Middle Aged mild cognitive impairment Miscellaneous Neuropsychological Tests Neuropsychology Prognosis Psychiatric Status Rating Scales Psychoanalysis Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Public health. Hygiene Public health. Hygiene-occupational medicine symptoms |
| title | Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of a clinical cohort |
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