Long-term tolerance to kidney allografts in a preclinical canine model
Durable immune tolerance supporting vascularized allotransplantation offers the possibility of extending graft survival and avoiding harmful complications of chronic immunosuppression. Immune tolerance to renal allografts was induced in a preclinical canine model through engraftment of donor hematop...
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| Veröffentlicht in: | Transplantation 2007-08, Vol.84 (4), p.545-547 |
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| container_title | Transplantation |
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| creator | KUHR, Christian S YUNUSOV, Murad SALE, George LORETZ, Carol STORB, Rainer |
| description | Durable immune tolerance supporting vascularized allotransplantation offers the possibility of extending graft survival and avoiding harmful complications of chronic immunosuppression. Immune tolerance to renal allografts was induced in a preclinical canine model through engraftment of donor hematopoietic cells using a combination of low-dose total body irradiation and a short course of immunosuppression. Subsequently, donor renal allografts were transplanted accompanied by bilateral native nephrectomies. With 5-year follow up, we found normal renal function in all recipients and no histological evidence of acute or chronic rejection. This tolerance does not extend universally to donor skin grafts, however, with two of four animals rejecting delayed donor skin grafts. Hematopoietic chimerism produces durable and robust immune tolerance to kidney allografts, although incomplete tolerance to donor skin grafting. |
| doi_str_mv | 10.1097/01.tp.0000270325.84036.52 |
| format | Article |
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Immune tolerance to renal allografts was induced in a preclinical canine model through engraftment of donor hematopoietic cells using a combination of low-dose total body irradiation and a short course of immunosuppression. Subsequently, donor renal allografts were transplanted accompanied by bilateral native nephrectomies. With 5-year follow up, we found normal renal function in all recipients and no histological evidence of acute or chronic rejection. This tolerance does not extend universally to donor skin grafts, however, with two of four animals rejecting delayed donor skin grafts. Hematopoietic chimerism produces durable and robust immune tolerance to kidney allografts, although incomplete tolerance to donor skin grafting.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/01.tp.0000270325.84036.52</identifier><identifier>PMID: 17713441</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Animals ; Biological and medical sciences ; Dogs ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft Survival - immunology ; Immune Tolerance - immunology ; Immunosuppression ; Kidney - pathology ; Kidney - physiology ; Kidney Transplantation - immunology ; Kidney Transplantation - pathology ; Kidney Transplantation - physiology ; Medical sciences ; Models, Animal ; Skin Transplantation - immunology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Time Factors ; Tissue, organ and graft immunology ; Transplantation Tolerance - immunology</subject><ispartof>Transplantation, 2007-08, Vol.84 (4), p.545-547</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-2f9f25f5c1c1468b1657ec3b959b87e68970aa86d24be941fe10f095f587c1153</citedby><cites>FETCH-LOGICAL-c427t-2f9f25f5c1c1468b1657ec3b959b87e68970aa86d24be941fe10f095f587c1153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19037782$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17713441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUHR, Christian S</creatorcontrib><creatorcontrib>YUNUSOV, Murad</creatorcontrib><creatorcontrib>SALE, George</creatorcontrib><creatorcontrib>LORETZ, Carol</creatorcontrib><creatorcontrib>STORB, Rainer</creatorcontrib><title>Long-term tolerance to kidney allografts in a preclinical canine model</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Durable immune tolerance supporting vascularized allotransplantation offers the possibility of extending graft survival and avoiding harmful complications of chronic immunosuppression. Immune tolerance to renal allografts was induced in a preclinical canine model through engraftment of donor hematopoietic cells using a combination of low-dose total body irradiation and a short course of immunosuppression. Subsequently, donor renal allografts were transplanted accompanied by bilateral native nephrectomies. With 5-year follow up, we found normal renal function in all recipients and no histological evidence of acute or chronic rejection. This tolerance does not extend universally to donor skin grafts, however, with two of four animals rejecting delayed donor skin grafts. Hematopoietic chimerism produces durable and robust immune tolerance to kidney allografts, although incomplete tolerance to donor skin grafting.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dogs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Survival - immunology</subject><subject>Immune Tolerance - immunology</subject><subject>Immunosuppression</subject><subject>Kidney - pathology</subject><subject>Kidney - physiology</subject><subject>Kidney Transplantation - immunology</subject><subject>Kidney Transplantation - pathology</subject><subject>Kidney Transplantation - physiology</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Skin Transplantation - immunology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Time Factors</subject><subject>Tissue, organ and graft immunology</subject><subject>Transplantation Tolerance - immunology</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1OHDEUha0IFDYkr4CGAroZ7vW_S4QCibRSmqS2PF4bTfD8YM8WvD3esNKWcWMX3znW_S4h1wgdglF3gN26dFAPVcCo6DQHJjtBP5ENCsZbCRrOyAaAY4uMqQvypZS_lRdMqc_kApVCxjluyON2np7bNeSxWecUspt8qK_mZdhN4a1xKc3P2cW1NMPUuGbJwadhGrxLjXfTMIVmnHchfSXn0aUSvh3vS_Ln8fvvhx_t9tfTz4f7bes5VWtLo4lUROHRI5e6RylU8Kw3wvRaBamNAue03FHeB8MxBoQIpia08lhHuyS3H71Lnl_3oax2HIoPKbkpzPtipUajFGP_BSlIKSQ7NJoP0Oe5lByiXfIwuvxmEezBtgW062JPtu0_21bQmr06frLvx7A7JY96K3BzBFypyuJB71BOnIG6D03ZO0dah1A</recordid><startdate>20070827</startdate><enddate>20070827</enddate><creator>KUHR, Christian S</creator><creator>YUNUSOV, Murad</creator><creator>SALE, George</creator><creator>LORETZ, Carol</creator><creator>STORB, Rainer</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070827</creationdate><title>Long-term tolerance to kidney allografts in a preclinical canine model</title><author>KUHR, Christian S ; YUNUSOV, Murad ; SALE, George ; LORETZ, Carol ; STORB, Rainer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-2f9f25f5c1c1468b1657ec3b959b87e68970aa86d24be941fe10f095f587c1153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dogs</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Graft Survival - immunology</topic><topic>Immune Tolerance - immunology</topic><topic>Immunosuppression</topic><topic>Kidney - pathology</topic><topic>Kidney - physiology</topic><topic>Kidney Transplantation - immunology</topic><topic>Kidney Transplantation - pathology</topic><topic>Kidney Transplantation - physiology</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Skin Transplantation - immunology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Time Factors</topic><topic>Tissue, organ and graft immunology</topic><topic>Transplantation Tolerance - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUHR, Christian S</creatorcontrib><creatorcontrib>YUNUSOV, Murad</creatorcontrib><creatorcontrib>SALE, George</creatorcontrib><creatorcontrib>LORETZ, Carol</creatorcontrib><creatorcontrib>STORB, Rainer</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUHR, Christian S</au><au>YUNUSOV, Murad</au><au>SALE, George</au><au>LORETZ, Carol</au><au>STORB, Rainer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term tolerance to kidney allografts in a preclinical canine model</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2007-08-27</date><risdate>2007</risdate><volume>84</volume><issue>4</issue><spage>545</spage><epage>547</epage><pages>545-547</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Durable immune tolerance supporting vascularized allotransplantation offers the possibility of extending graft survival and avoiding harmful complications of chronic immunosuppression. Immune tolerance to renal allografts was induced in a preclinical canine model through engraftment of donor hematopoietic cells using a combination of low-dose total body irradiation and a short course of immunosuppression. Subsequently, donor renal allografts were transplanted accompanied by bilateral native nephrectomies. With 5-year follow up, we found normal renal function in all recipients and no histological evidence of acute or chronic rejection. This tolerance does not extend universally to donor skin grafts, however, with two of four animals rejecting delayed donor skin grafts. Hematopoietic chimerism produces durable and robust immune tolerance to kidney allografts, although incomplete tolerance to donor skin grafting.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>17713441</pmid><doi>10.1097/01.tp.0000270325.84036.52</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Transplantation, 2007-08, Vol.84 (4), p.545-547 |
| issn | 0041-1337 1534-6080 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Dogs Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Survival - immunology Immune Tolerance - immunology Immunosuppression Kidney - pathology Kidney - physiology Kidney Transplantation - immunology Kidney Transplantation - pathology Kidney Transplantation - physiology Medical sciences Models, Animal Skin Transplantation - immunology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors Tissue, organ and graft immunology Transplantation Tolerance - immunology |
| title | Long-term tolerance to kidney allografts in a preclinical canine model |
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