Chk1 Instability Is Coupled to Mitotic Cell Death of p53-deficient Cells in Response to Virus-induced DNA Damage Signaling

Adeno-associated virus (AAV) DNA, by mimicking a stalled replication fork, provokes a DNA damage response that can arrest cells in the G2/M phase of the cell-cycle. This response depends strictly on DNA damage signaling kinases ATR and Chk1. Here, we used AAV to study long-term effects of DNA damage...

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Veröffentlicht in:	Journal of molecular biology 2007-09, Vol.372 (2), p.397-406
Hauptverfasser:	Jurvansuu, Jaana, Fragkos, Michalis, Ingemarsdotter, Carin, Beard, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus cdc25 Phosphatases - antagonists & inhibitors cdc25 Phosphatases - metabolism Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - metabolism Cell Death Cell Line Checkpoint Kinase 1 Chk1 Chromosomes - genetics Cyclin B - antagonists & inhibitors Cyclin B - metabolism Cyclin B1 Dependovirus - genetics Dependovirus - physiology DNA Damage DNA damage signaling Enzyme Stability Metaphase Mitosis p53 Polo-Like Kinase 1 Protein Kinases - metabolism Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - metabolism Signal Transduction Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics
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