Novobiocin: Redesigning a DNA Gyrase Inhibitor for Selective Inhibition of Hsp90

Novobiocin is a member of the coumermycin family of antibiotics and is a well-established inhibitor of DNA gyrase. Recent studies have shown that novobiocin binds to a previously unrecognized ATP-binding site at the C-terminus of Hsp90 and induces degradation of Hsp90-dependent client proteins at ∼7...

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Veröffentlicht in:	Journal of the American Chemical Society 2006-12, Vol.128 (48), p.15529-15536
Hauptverfasser:	Burlison, Joseph A, Neckers, Len, Smith, Andrew B, Maxwell, Anthony, Blagg, Brian S. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Blotting, Western Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides Carbohydrates. Nucleosides and nucleotides Cell Line, Tumor Cell Survival - drug effects Chemistry Exact sciences and technology General and physical chemistry Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives HSP90 Heat-Shock Proteins - antagonists & inhibitors Humans Molecular Structure Novobiocin - analogs & derivatives Novobiocin - chemical synthesis Novobiocin - pharmacology Nucleosides, nucleotides and oligonucleotides Organic chemistry Preparations and properties Protein Folding Structure-Activity Relationship Substrate Specificity Topoisomerase II Inhibitors
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