Effect of the ABO blood group on the proliferative and clonogenic capacity of umbilical cord stem cells
Possible effects of the ABO blood group on the proliferative and self-renewal capacity of umbilical cord CD34+ cells were evaluated. A, B and O (all Rh D+) CD34+ cells isolated from three placental blood samples were cultured in four platforms with hematopoietic growth factors on a 3-dimensional bio...
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| Veröffentlicht in: | Transfusion and apheresis science 2006-10, Vol.35 (2), p.119-123 |
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| container_title | Transfusion and apheresis science |
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| creator | Galan, Isabel Santolaya-Forgas, Joaquin Leon, Juan De Uhlmann, Rebecca A. Montenegro, Daniel Hume, Roderick Mari, Giancarlo |
| description | Possible effects of the ABO blood group on the proliferative and self-renewal capacity of umbilical cord CD34+ cells were evaluated. A, B and O (all Rh D+) CD34+ cells isolated from three placental blood samples were cultured in four platforms with hematopoietic growth factors on a 3-dimensional biocompatible matrix. Results from this study suggest that proliferation of CD34+ cells with the O phenotype may be greater than that of cells with the A or B phenotypes. Further
ex vivo studies are required to confirm this finding and to determine the effect of the number and type of other genetically determined cell surface antigens on the capacity of hematopoietic stem cells to respond to cytokines. In addition, clinical studies aimed at determining if the CD34+ donor blood group affects the time to functional hematological reconstitution are recommended. |
| doi_str_mv | 10.1016/j.transci.2006.05.012 |
| format | Article |
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ex vivo studies are required to confirm this finding and to determine the effect of the number and type of other genetically determined cell surface antigens on the capacity of hematopoietic stem cells to respond to cytokines. In addition, clinical studies aimed at determining if the CD34+ donor blood group affects the time to functional hematological reconstitution are recommended.</description><identifier>ISSN: 1473-0502</identifier><identifier>EISSN: 1878-1683</identifier><identifier>DOI: 10.1016/j.transci.2006.05.012</identifier><identifier>PMID: 17045528</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>ABO Blood-Group System - genetics ; Antigens, CD34 - genetics ; Cell Culture Techniques ; Cell Proliferation - drug effects ; Cells, Cultured ; Female ; Health technology assessment ; Hematopoiesis ; Hematopoietic Stem Cells - cytology ; Humans ; Infant, Newborn ; Intercellular Signaling Peptides and Proteins - pharmacology ; Male ; Umbilical Cord - cytology</subject><ispartof>Transfusion and apheresis science, 2006-10, Vol.35 (2), p.119-123</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-e02cff4fbc3befad01d3293310ad6082b74971ace47706096d217219dad502f43</citedby><cites>FETCH-LOGICAL-c363t-e02cff4fbc3befad01d3293310ad6082b74971ace47706096d217219dad502f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1473050206001121$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17045528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galan, Isabel</creatorcontrib><creatorcontrib>Santolaya-Forgas, Joaquin</creatorcontrib><creatorcontrib>Leon, Juan De</creatorcontrib><creatorcontrib>Uhlmann, Rebecca A.</creatorcontrib><creatorcontrib>Montenegro, Daniel</creatorcontrib><creatorcontrib>Hume, Roderick</creatorcontrib><creatorcontrib>Mari, Giancarlo</creatorcontrib><title>Effect of the ABO blood group on the proliferative and clonogenic capacity of umbilical cord stem cells</title><title>Transfusion and apheresis science</title><addtitle>Transfus Apher Sci</addtitle><description>Possible effects of the ABO blood group on the proliferative and self-renewal capacity of umbilical cord CD34+ cells were evaluated. A, B and O (all Rh D+) CD34+ cells isolated from three placental blood samples were cultured in four platforms with hematopoietic growth factors on a 3-dimensional biocompatible matrix. Results from this study suggest that proliferation of CD34+ cells with the O phenotype may be greater than that of cells with the A or B phenotypes. Further
ex vivo studies are required to confirm this finding and to determine the effect of the number and type of other genetically determined cell surface antigens on the capacity of hematopoietic stem cells to respond to cytokines. In addition, clinical studies aimed at determining if the CD34+ donor blood group affects the time to functional hematological reconstitution are recommended.</description><subject>ABO Blood-Group System - genetics</subject><subject>Antigens, CD34 - genetics</subject><subject>Cell Culture Techniques</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells, Cultured</subject><subject>Female</subject><subject>Health technology assessment</subject><subject>Hematopoiesis</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Intercellular Signaling Peptides and Proteins - pharmacology</subject><subject>Male</subject><subject>Umbilical Cord - cytology</subject><issn>1473-0502</issn><issn>1878-1683</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9r3DAQxUVpaP5-hBaderMzkmzJPoU0pEkgkEt7FrI02mqxrY1kB_Lto-0u9NjTDMObN29-hHxlUDNg8npbL8nM2YaaA8ga2hoY_0TOWKe6islOfC59o0QFLfBTcp7zFoAp1ssv5JQpaNqWd2dkc-892oVGT5c_SG9_vNBhjNHRTYrrjsb573iX4hg8JrOEN6RmdtSOcY4bnIOl1uyMDcv73mOdhjAGa0ZqY3I0LzhRi-OYL8mJN2PGq2O9IL9_3v-6e6yeXx6e7m6fKyukWCoEbr1v_GDFgN44YE7wXggGxkno-KCaXjFjsVEKJPTScaY4651x5U3fiAvy_eBbIr-umBc9hbxPYGaMa9ayKwQ6zouwPQhtijkn9HqXwmTSu2ag94T1Vh8J6z1hDa0uhMvet-OBdZjQ_ds6Ii2Cm4MAy5tvAZMuFjhbdCEV0trF8J8TH6TIj9Y</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Galan, Isabel</creator><creator>Santolaya-Forgas, Joaquin</creator><creator>Leon, Juan De</creator><creator>Uhlmann, Rebecca A.</creator><creator>Montenegro, Daniel</creator><creator>Hume, Roderick</creator><creator>Mari, Giancarlo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Effect of the ABO blood group on the proliferative and clonogenic capacity of umbilical cord stem cells</title><author>Galan, Isabel ; Santolaya-Forgas, Joaquin ; Leon, Juan De ; Uhlmann, Rebecca A. ; Montenegro, Daniel ; Hume, Roderick ; Mari, Giancarlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-e02cff4fbc3befad01d3293310ad6082b74971ace47706096d217219dad502f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ABO Blood-Group System - genetics</topic><topic>Antigens, CD34 - genetics</topic><topic>Cell Culture Techniques</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells, Cultured</topic><topic>Female</topic><topic>Health technology assessment</topic><topic>Hematopoiesis</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Intercellular Signaling Peptides and Proteins - pharmacology</topic><topic>Male</topic><topic>Umbilical Cord - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galan, Isabel</creatorcontrib><creatorcontrib>Santolaya-Forgas, Joaquin</creatorcontrib><creatorcontrib>Leon, Juan De</creatorcontrib><creatorcontrib>Uhlmann, Rebecca A.</creatorcontrib><creatorcontrib>Montenegro, Daniel</creatorcontrib><creatorcontrib>Hume, Roderick</creatorcontrib><creatorcontrib>Mari, Giancarlo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion and apheresis science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galan, Isabel</au><au>Santolaya-Forgas, Joaquin</au><au>Leon, Juan De</au><au>Uhlmann, Rebecca A.</au><au>Montenegro, Daniel</au><au>Hume, Roderick</au><au>Mari, Giancarlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of the ABO blood group on the proliferative and clonogenic capacity of umbilical cord stem cells</atitle><jtitle>Transfusion and apheresis science</jtitle><addtitle>Transfus Apher Sci</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>35</volume><issue>2</issue><spage>119</spage><epage>123</epage><pages>119-123</pages><issn>1473-0502</issn><eissn>1878-1683</eissn><abstract>Possible effects of the ABO blood group on the proliferative and self-renewal capacity of umbilical cord CD34+ cells were evaluated. A, B and O (all Rh D+) CD34+ cells isolated from three placental blood samples were cultured in four platforms with hematopoietic growth factors on a 3-dimensional biocompatible matrix. Results from this study suggest that proliferation of CD34+ cells with the O phenotype may be greater than that of cells with the A or B phenotypes. Further
ex vivo studies are required to confirm this finding and to determine the effect of the number and type of other genetically determined cell surface antigens on the capacity of hematopoietic stem cells to respond to cytokines. In addition, clinical studies aimed at determining if the CD34+ donor blood group affects the time to functional hematological reconstitution are recommended.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17045528</pmid><doi>10.1016/j.transci.2006.05.012</doi><tpages>5</tpages></addata></record> |
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| ispartof | Transfusion and apheresis science, 2006-10, Vol.35 (2), p.119-123 |
| issn | 1473-0502 1878-1683 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ABO Blood-Group System - genetics Antigens, CD34 - genetics Cell Culture Techniques Cell Proliferation - drug effects Cells, Cultured Female Health technology assessment Hematopoiesis Hematopoietic Stem Cells - cytology Humans Infant, Newborn Intercellular Signaling Peptides and Proteins - pharmacology Male Umbilical Cord - cytology |
| title | Effect of the ABO blood group on the proliferative and clonogenic capacity of umbilical cord stem cells |
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