Cardioprotective Effect of Edaravone against Ischaemia–Reperfusion Injury in the Rabbit Heart Before, during and after Reperfusion Treatment
The free radical scavenger edaravone is able to stimulate prostacyclin release and inhibit the lipoxygenase pathway in the arachidonic acid cascade. The effect of edaravone administration on myocardial damage in rabbit hearts subjected to ischaemia–reperfusion was examined at different times relativ...
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| Veröffentlicht in: | Journal of international medical research 2006-09, Vol.34 (5), p.475-484 |
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| creator | Fukuda, A Okubo, S Tanabe, Y Hoshiba, Y Shiobara, H Harafuji, K Kobori, Y Fujinawa, M Okubo, T Yamashina, A |
| description | The free radical scavenger edaravone is able to stimulate prostacyclin release and inhibit the lipoxygenase pathway in the arachidonic acid cascade. The effect of edaravone administration on myocardial damage in rabbit hearts subjected to ischaemia–reperfusion was examined at different times relative to reperfusion. All rabbits underwent sustained coronary artery occlusion for 30 min followed by 3 h of reperfusion. Rabbits were divided into the following groups: control; early (3 mg/kg edaravone IV 10 min before reperfusion); immediate (3 mg/kg edaravone IV immediately after the start of reperfusion); and late (3, 6 or 10 mg/kg edaravone IV 5 min after the start of reperfusion). Single bolus administration of edaravone 10 min before reperfusion or immediately upon initiation of reperfusion appears to be associated with reductions in infarction size and the percentage of apoptotic cells, but treatment with edaravone 5 min after initiation of reperfusion does not appear to have this protective effect. |
| doi_str_mv | 10.1177/147323000603400504 |
| format | Article |
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The effect of edaravone administration on myocardial damage in rabbit hearts subjected to ischaemia–reperfusion was examined at different times relative to reperfusion. All rabbits underwent sustained coronary artery occlusion for 30 min followed by 3 h of reperfusion. Rabbits were divided into the following groups: control; early (3 mg/kg edaravone IV 10 min before reperfusion); immediate (3 mg/kg edaravone IV immediately after the start of reperfusion); and late (3, 6 or 10 mg/kg edaravone IV 5 min after the start of reperfusion). Single bolus administration of edaravone 10 min before reperfusion or immediately upon initiation of reperfusion appears to be associated with reductions in infarction size and the percentage of apoptotic cells, but treatment with edaravone 5 min after initiation of reperfusion does not appear to have this protective effect.</description><identifier>ISSN: 0300-0605</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/147323000603400504</identifier><identifier>PMID: 17133776</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Antipyrine - administration & dosage ; Antipyrine - analogs & derivatives ; Antipyrine - pharmacology ; Apoptosis - drug effects ; Cardiotonic Agents - administration & dosage ; Cardiotonic Agents - pharmacology ; DNA Fragmentation - drug effects ; Drug Evaluation, Preclinical ; Free Radical Scavengers - therapeutic use ; Myocardial Infarction - drug therapy ; Myocardial Infarction - prevention & control ; Myocardial Reperfusion Injury - drug therapy ; Myocardial Reperfusion Injury - pathology ; Myocardial Reperfusion Injury - prevention & control ; Rabbits ; Time Factors</subject><ispartof>Journal of international medical research, 2006-09, Vol.34 (5), p.475-484</ispartof><rights>2006 SAGE Publications</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-c4bc4b3ff3a34e1be8aa3fe8f6cf6e56d3b1d18dfb4b174dd9f1b8edd4eec9f13</citedby><cites>FETCH-LOGICAL-c407t-c4bc4b3ff3a34e1be8aa3fe8f6cf6e56d3b1d18dfb4b174dd9f1b8edd4eec9f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/147323000603400504$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/147323000603400504$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/147323000603400504?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17133776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukuda, A</creatorcontrib><creatorcontrib>Okubo, S</creatorcontrib><creatorcontrib>Tanabe, Y</creatorcontrib><creatorcontrib>Hoshiba, Y</creatorcontrib><creatorcontrib>Shiobara, H</creatorcontrib><creatorcontrib>Harafuji, K</creatorcontrib><creatorcontrib>Kobori, Y</creatorcontrib><creatorcontrib>Fujinawa, M</creatorcontrib><creatorcontrib>Okubo, T</creatorcontrib><creatorcontrib>Yamashina, A</creatorcontrib><title>Cardioprotective Effect of Edaravone against Ischaemia–Reperfusion Injury in the Rabbit Heart Before, during and after Reperfusion Treatment</title><title>Journal of international medical research</title><addtitle>J Int Med Res</addtitle><description>The free radical scavenger edaravone is able to stimulate prostacyclin release and inhibit the lipoxygenase pathway in the arachidonic acid cascade. 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Single bolus administration of edaravone 10 min before reperfusion or immediately upon initiation of reperfusion appears to be associated with reductions in infarction size and the percentage of apoptotic cells, but treatment with edaravone 5 min after initiation of reperfusion does not appear to have this protective effect.</description><subject>Animals</subject><subject>Antipyrine - administration & dosage</subject><subject>Antipyrine - analogs & derivatives</subject><subject>Antipyrine - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Cardiotonic Agents - administration & dosage</subject><subject>Cardiotonic Agents - pharmacology</subject><subject>DNA Fragmentation - drug effects</subject><subject>Drug Evaluation, Preclinical</subject><subject>Free Radical Scavengers - therapeutic use</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Infarction - prevention & control</subject><subject>Myocardial Reperfusion Injury - drug therapy</subject><subject>Myocardial Reperfusion Injury - pathology</subject><subject>Myocardial Reperfusion Injury - prevention & control</subject><subject>Rabbits</subject><subject>Time Factors</subject><issn>0300-0605</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UV1LYzEQDeKi9eMP7MOSJ5_smjRp7vVxt1QtCIK4z5fJzaSm9CY1yS345i_wxX_oLzGlBYUFYZg5zJxzYGYI-cnZb86r6oLLSowEY0wxIRkbM7lHBpvmcNPdJwNWyrBMx4fkKKUFY3KkxqMDcsgrLkRVqQF5nUA0LqxiyNhmt0Y6tbYgGiydGoiwDh4pzMH5lOkstY-AnYP3l7d7XGG0fXLB05lf9PGZOk_zI9J70NpleoMQM_2LNkQ8p6aPzs8peEPBZoz0q_4hIuQOfT4hPywsE57u6jH5dzV9mNwMb--uZ5M_t8NWsiqXrEsIawUIiVxjDSAs1la1VuFYGaG54bWxWmpeSWMuLdc1GiMR24LFMTnb-pbFn3pMuelcanG5BI-hT42q-aWSakMcbYltDClFtM0qug7ic8NZs_lC8_8XiujXzr3XHZpPye7shXCxJSSYY7MIffRl2-8sPwA4FpSc</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Fukuda, A</creator><creator>Okubo, S</creator><creator>Tanabe, Y</creator><creator>Hoshiba, Y</creator><creator>Shiobara, H</creator><creator>Harafuji, K</creator><creator>Kobori, Y</creator><creator>Fujinawa, M</creator><creator>Okubo, T</creator><creator>Yamashina, A</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Cardioprotective Effect of Edaravone against Ischaemia–Reperfusion Injury in the Rabbit Heart Before, during and after Reperfusion Treatment</title><author>Fukuda, A ; 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The effect of edaravone administration on myocardial damage in rabbit hearts subjected to ischaemia–reperfusion was examined at different times relative to reperfusion. All rabbits underwent sustained coronary artery occlusion for 30 min followed by 3 h of reperfusion. Rabbits were divided into the following groups: control; early (3 mg/kg edaravone IV 10 min before reperfusion); immediate (3 mg/kg edaravone IV immediately after the start of reperfusion); and late (3, 6 or 10 mg/kg edaravone IV 5 min after the start of reperfusion). Single bolus administration of edaravone 10 min before reperfusion or immediately upon initiation of reperfusion appears to be associated with reductions in infarction size and the percentage of apoptotic cells, but treatment with edaravone 5 min after initiation of reperfusion does not appear to have this protective effect.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>17133776</pmid><doi>10.1177/147323000603400504</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of international medical research, 2006-09, Vol.34 (5), p.475-484 |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Animals Antipyrine - administration & dosage Antipyrine - analogs & derivatives Antipyrine - pharmacology Apoptosis - drug effects Cardiotonic Agents - administration & dosage Cardiotonic Agents - pharmacology DNA Fragmentation - drug effects Drug Evaluation, Preclinical Free Radical Scavengers - therapeutic use Myocardial Infarction - drug therapy Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Rabbits Time Factors |
| title | Cardioprotective Effect of Edaravone against Ischaemia–Reperfusion Injury in the Rabbit Heart Before, during and after Reperfusion Treatment |
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