Effect of arundic acid on serum S-100beta in ischemic stroke
We prospectively examined the effect of arundic acid (AA; ONO-2506) on S-100beta, an astrocyte-derived protein, in a phase I acute stroke study. Subjects with acute ischemic stroke were randomized to daily infusion of AA or placebo for 7 days. Serum S-100beta levels were assayed pre-infusion on Days...
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| Veröffentlicht in: | Journal of the neurological sciences 2006-12, Vol.251 (1-2), p.57-61 |
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| container_title | Journal of the neurological sciences |
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| creator | Pettigrew, L Creed Kasner, Scott E Gorman, Mark Atkinson, Richard P Funakoshi, Yosuke Ishibashi, Hideyasu |
| description | We prospectively examined the effect of arundic acid (AA; ONO-2506) on S-100beta, an astrocyte-derived protein, in a phase I acute stroke study. Subjects with acute ischemic stroke were randomized to daily infusion of AA or placebo for 7 days. Serum S-100beta levels were assayed pre-infusion on Days 1-7 and post-infusion on Days 1, 3, and 7, and correlated with National Institutes of Health Stroke Scale (NIHSS). Samples were obtained from 86 subjects (46 AA, 40 placebo). Increase in S-100beta protein level from baseline was less in the AA cohort than in the placebo cohort at 7 (p=0.0471; t-test) and 12 (p=0.0095)-hours post-infusion on Day 3. Baseline NIHSS correlated with maximal S-100beta levels between Days 1 and 3 in the AA (r=0.51; p=0.0003) and placebo (r=0.41; p=0.0084) cohorts and in the pooled aggregate (n=86; r=0.46; p |
| format | Article |
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Subjects with acute ischemic stroke were randomized to daily infusion of AA or placebo for 7 days. Serum S-100beta levels were assayed pre-infusion on Days 1-7 and post-infusion on Days 1, 3, and 7, and correlated with National Institutes of Health Stroke Scale (NIHSS). Samples were obtained from 86 subjects (46 AA, 40 placebo). Increase in S-100beta protein level from baseline was less in the AA cohort than in the placebo cohort at 7 (p=0.0471; t-test) and 12 (p=0.0095)-hours post-infusion on Day 3. Baseline NIHSS correlated with maximal S-100beta levels between Days 1 and 3 in the AA (r=0.51; p=0.0003) and placebo (r=0.41; p=0.0084) cohorts and in the pooled aggregate (n=86; r=0.46; p<0.0001). The same correlations were observed between Day 10 NIHSS and Day 1-3 maximum serum S-100beta levels. Treatment with AA was associated with lower serum levels of S-100beta after acute ischemic stroke. Our results showing correlation between S-100beta and NIHSS indicate that this protein is a clinically relevant marker of neurological deficit in acute stroke.</description><identifier>ISSN: 0022-510X</identifier><identifier>PMID: 17092520</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Aged ; Aged, 80 and over ; Analysis of Variance ; Brain Ischemia - blood ; Brain Ischemia - drug therapy ; Caprylates - pharmacology ; Caprylates - therapeutic use ; Cohort Studies ; Dose-Response Relationship, Drug ; Double-Blind Method ; Enzyme-Linked Immunosorbent Assay - methods ; Female ; Humans ; Male ; Middle Aged ; Nerve Growth Factors - blood ; S100 Calcium Binding Protein beta Subunit ; S100 Proteins - blood ; Severity of Illness Index ; Statistics, Nonparametric ; Time Factors</subject><ispartof>Journal of the neurological sciences, 2006-12, Vol.251 (1-2), p.57-61</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17092520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pettigrew, L Creed</creatorcontrib><creatorcontrib>Kasner, Scott E</creatorcontrib><creatorcontrib>Gorman, Mark</creatorcontrib><creatorcontrib>Atkinson, Richard P</creatorcontrib><creatorcontrib>Funakoshi, Yosuke</creatorcontrib><creatorcontrib>Ishibashi, Hideyasu</creatorcontrib><creatorcontrib>Arundic Acid (ONO-2506) Stroke Study Group</creatorcontrib><title>Effect of arundic acid on serum S-100beta in ischemic stroke</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>We prospectively examined the effect of arundic acid (AA; ONO-2506) on S-100beta, an astrocyte-derived protein, in a phase I acute stroke study. Subjects with acute ischemic stroke were randomized to daily infusion of AA or placebo for 7 days. Serum S-100beta levels were assayed pre-infusion on Days 1-7 and post-infusion on Days 1, 3, and 7, and correlated with National Institutes of Health Stroke Scale (NIHSS). Samples were obtained from 86 subjects (46 AA, 40 placebo). Increase in S-100beta protein level from baseline was less in the AA cohort than in the placebo cohort at 7 (p=0.0471; t-test) and 12 (p=0.0095)-hours post-infusion on Day 3. Baseline NIHSS correlated with maximal S-100beta levels between Days 1 and 3 in the AA (r=0.51; p=0.0003) and placebo (r=0.41; p=0.0084) cohorts and in the pooled aggregate (n=86; r=0.46; p<0.0001). The same correlations were observed between Day 10 NIHSS and Day 1-3 maximum serum S-100beta levels. Treatment with AA was associated with lower serum levels of S-100beta after acute ischemic stroke. Our results showing correlation between S-100beta and NIHSS indicate that this protein is a clinically relevant marker of neurological deficit in acute stroke.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Brain Ischemia - blood</subject><subject>Brain Ischemia - drug therapy</subject><subject>Caprylates - pharmacology</subject><subject>Caprylates - therapeutic use</subject><subject>Cohort Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nerve Growth Factors - blood</subject><subject>S100 Calcium Binding Protein beta Subunit</subject><subject>S100 Proteins - blood</subject><subject>Severity of Illness Index</subject><subject>Statistics, Nonparametric</subject><subject>Time Factors</subject><issn>0022-510X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1zztPwzAUBWAPoLa0_AXkiS3StRM7tsSCqvKQKjHQgS3y41oE4iTYycC_JxLtdJZPR-dckQ0A54Vg8LEmNzl_AYBUSq_ImtWgueCwIQ-HENBNdAjUpLn3raPGtZ4OPc2Y5kjfCwZgcTK07Wmb3SfGxeQpDd-4I9fBdBlvz7klp6fDaf9SHN-eX_ePx2IUFRTcCrC1CgYrrdEZj6FWnumS6TqUqFA4UUkOKK3Xtgq2DkEx4y0owaUsyy25_68d0_AzY56auAzBrjM9DnNupGK6Ykwt8O4MZxvRN2Nqo0m_zeVu-Qfj207j</recordid><startdate>20061221</startdate><enddate>20061221</enddate><creator>Pettigrew, L Creed</creator><creator>Kasner, Scott E</creator><creator>Gorman, Mark</creator><creator>Atkinson, Richard P</creator><creator>Funakoshi, Yosuke</creator><creator>Ishibashi, Hideyasu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20061221</creationdate><title>Effect of arundic acid on serum S-100beta in ischemic stroke</title><author>Pettigrew, L Creed ; Kasner, Scott E ; Gorman, Mark ; Atkinson, Richard P ; Funakoshi, Yosuke ; Ishibashi, Hideyasu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p540-2b50b78fae499ecadef78d193197f3e8e5c54620e6bd9b4fb7ff81adb08526633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Brain Ischemia - blood</topic><topic>Brain Ischemia - drug therapy</topic><topic>Caprylates - pharmacology</topic><topic>Caprylates - therapeutic use</topic><topic>Cohort Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Enzyme-Linked Immunosorbent Assay - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nerve Growth Factors - blood</topic><topic>S100 Calcium Binding Protein beta Subunit</topic><topic>S100 Proteins - blood</topic><topic>Severity of Illness Index</topic><topic>Statistics, Nonparametric</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pettigrew, L Creed</creatorcontrib><creatorcontrib>Kasner, Scott E</creatorcontrib><creatorcontrib>Gorman, Mark</creatorcontrib><creatorcontrib>Atkinson, Richard P</creatorcontrib><creatorcontrib>Funakoshi, Yosuke</creatorcontrib><creatorcontrib>Ishibashi, Hideyasu</creatorcontrib><creatorcontrib>Arundic Acid (ONO-2506) Stroke Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pettigrew, L Creed</au><au>Kasner, Scott E</au><au>Gorman, Mark</au><au>Atkinson, Richard P</au><au>Funakoshi, Yosuke</au><au>Ishibashi, Hideyasu</au><aucorp>Arundic Acid (ONO-2506) Stroke Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of arundic acid on serum S-100beta in ischemic stroke</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2006-12-21</date><risdate>2006</risdate><volume>251</volume><issue>1-2</issue><spage>57</spage><epage>61</epage><pages>57-61</pages><issn>0022-510X</issn><abstract>We prospectively examined the effect of arundic acid (AA; ONO-2506) on S-100beta, an astrocyte-derived protein, in a phase I acute stroke study. Subjects with acute ischemic stroke were randomized to daily infusion of AA or placebo for 7 days. Serum S-100beta levels were assayed pre-infusion on Days 1-7 and post-infusion on Days 1, 3, and 7, and correlated with National Institutes of Health Stroke Scale (NIHSS). Samples were obtained from 86 subjects (46 AA, 40 placebo). Increase in S-100beta protein level from baseline was less in the AA cohort than in the placebo cohort at 7 (p=0.0471; t-test) and 12 (p=0.0095)-hours post-infusion on Day 3. Baseline NIHSS correlated with maximal S-100beta levels between Days 1 and 3 in the AA (r=0.51; p=0.0003) and placebo (r=0.41; p=0.0084) cohorts and in the pooled aggregate (n=86; r=0.46; p<0.0001). The same correlations were observed between Day 10 NIHSS and Day 1-3 maximum serum S-100beta levels. Treatment with AA was associated with lower serum levels of S-100beta after acute ischemic stroke. Our results showing correlation between S-100beta and NIHSS indicate that this protein is a clinically relevant marker of neurological deficit in acute stroke.</abstract><cop>Netherlands</cop><pmid>17092520</pmid><tpages>5</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Analysis of Variance Brain Ischemia - blood Brain Ischemia - drug therapy Caprylates - pharmacology Caprylates - therapeutic use Cohort Studies Dose-Response Relationship, Drug Double-Blind Method Enzyme-Linked Immunosorbent Assay - methods Female Humans Male Middle Aged Nerve Growth Factors - blood S100 Calcium Binding Protein beta Subunit S100 Proteins - blood Severity of Illness Index Statistics, Nonparametric Time Factors |
| title | Effect of arundic acid on serum S-100beta in ischemic stroke |
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