Mast cells in testicular biopsies of azoospermic men
Summary This work aimed at identifying mast cells in testicular biopsies from 10 normal fertile controls, 20 patients with obstructive azoospermia and 70 patients with nonobstructive azoospermia. The biopsies were stained with haematoxylin and eosin stain for tubular‐modified Johnson score and with...
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| Veröffentlicht in: | Andrologia 2007-10, Vol.39 (5), p.185-189 |
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| creator | Roaiah, M. M. F. Khatab, H. Mostafa, T. |
| description | Summary
This work aimed at identifying mast cells in testicular biopsies from 10 normal fertile controls, 20 patients with obstructive azoospermia and 70 patients with nonobstructive azoospermia. The biopsies were stained with haematoxylin and eosin stain for tubular‐modified Johnson score and with toluidine blue stain for mast cells. Two populations of mast cells, peritubular and interstitial, were demonstrated in all sections with varied counts. Testicular sections with Sertoli cell only and spermatogenic arrest patterns demonstrated a significant increase in both peritubular and interstitial mast cells compared with other groups, whereas obstructive azoospermia demonstrated a nonsignificant increase compared with the controls. Mast cell count was significantly correlated negatively with Johnson score for both peritubular (P = 0.001) and interstitial (P = 0.001) populations. Whether these results could be a cause or an effect, a special role might be assigned to mast cells in the pathogenesis of disturbed spermatogenesis. |
| doi_str_mv | 10.1111/j.1439-0272.2007.00793.x |
| format | Article |
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This work aimed at identifying mast cells in testicular biopsies from 10 normal fertile controls, 20 patients with obstructive azoospermia and 70 patients with nonobstructive azoospermia. The biopsies were stained with haematoxylin and eosin stain for tubular‐modified Johnson score and with toluidine blue stain for mast cells. Two populations of mast cells, peritubular and interstitial, were demonstrated in all sections with varied counts. Testicular sections with Sertoli cell only and spermatogenic arrest patterns demonstrated a significant increase in both peritubular and interstitial mast cells compared with other groups, whereas obstructive azoospermia demonstrated a nonsignificant increase compared with the controls. Mast cell count was significantly correlated negatively with Johnson score for both peritubular (P = 0.001) and interstitial (P = 0.001) populations. Whether these results could be a cause or an effect, a special role might be assigned to mast cells in the pathogenesis of disturbed spermatogenesis.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/j.1439-0272.2007.00793.x</identifier><identifier>PMID: 17714217</identifier><identifier>CODEN: ANDRDQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Azoospermia ; Azoospermia - pathology ; Azoospermia - physiopathology ; Biological and medical sciences ; Biopsy ; Birth control ; Case-Control Studies ; Cell Count ; Gynecology. Andrology. Obstetrics ; Humans ; Male ; Male genital diseases ; male infertility ; mast cells ; Mast Cells - pathology ; Mast Cells - physiology ; Medical sciences ; Middle Aged ; Spermatogenesis - physiology ; Sterility. Assisted procreation ; testis ; Testis - pathology ; Testis - physiopathology ; testis biopsy</subject><ispartof>Andrologia, 2007-10, Vol.39 (5), p.185-189</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4843-14ca9d4decf02e2e13ccca845d57afb778d97fa6990608019fb80a2a15c75f763</citedby><cites>FETCH-LOGICAL-c4843-14ca9d4decf02e2e13ccca845d57afb778d97fa6990608019fb80a2a15c75f763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1439-0272.2007.00793.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1439-0272.2007.00793.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19018220$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17714217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roaiah, M. M. F.</creatorcontrib><creatorcontrib>Khatab, H.</creatorcontrib><creatorcontrib>Mostafa, T.</creatorcontrib><title>Mast cells in testicular biopsies of azoospermic men</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>Summary
This work aimed at identifying mast cells in testicular biopsies from 10 normal fertile controls, 20 patients with obstructive azoospermia and 70 patients with nonobstructive azoospermia. The biopsies were stained with haematoxylin and eosin stain for tubular‐modified Johnson score and with toluidine blue stain for mast cells. Two populations of mast cells, peritubular and interstitial, were demonstrated in all sections with varied counts. Testicular sections with Sertoli cell only and spermatogenic arrest patterns demonstrated a significant increase in both peritubular and interstitial mast cells compared with other groups, whereas obstructive azoospermia demonstrated a nonsignificant increase compared with the controls. Mast cell count was significantly correlated negatively with Johnson score for both peritubular (P = 0.001) and interstitial (P = 0.001) populations. Whether these results could be a cause or an effect, a special role might be assigned to mast cells in the pathogenesis of disturbed spermatogenesis.</description><subject>Adult</subject><subject>Azoospermia</subject><subject>Azoospermia - pathology</subject><subject>Azoospermia - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Birth control</subject><subject>Case-Control Studies</subject><subject>Cell Count</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>male infertility</subject><subject>mast cells</subject><subject>Mast Cells - pathology</subject><subject>Mast Cells - physiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Spermatogenesis - physiology</subject><subject>Sterility. Assisted procreation</subject><subject>testis</subject><subject>Testis - pathology</subject><subject>Testis - physiopathology</subject><subject>testis biopsy</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkFtLwzAYhoMobsz9BemN3rXm1CYBb4ZnnIqgeBnSNIHMdq1Jh9Nfb-rGvPWDkECeN3l5AEgQzFCcs0WGKBEpxAxnGEKWxSVItt4D493FPhhDAklK80KMwDSEBYxDc8YoPQQjxBiiGLExoA8q9Ik2dR0St0x6E3qnV7XySenaLjgTktYm6rttQ2d843TSmOUROLCqDma63Sfg9frq5eI2nT_d3F3M5qmmnJIUUa1ERSujLcQGG0S01orTvMqZsiVjvBLMqkIIWEAOkbAlhworlGuWW1aQCTjdvNv59mMVq8nGhaGrWpp2FWTBkSAFGkC-AbVvQ_DGys67RvkviaAcpMmFHNzIwY0cpMlfaXIdo8fbP1ZlY6q_4FZRBE62gApa1darpXbhjxMQcYxh5M433Kerzde_C8jZ42U8xHi6ibvQm_Uurvy7LBhhuXx7vJH37Jby5_xFPpAfyqiVVA</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Roaiah, M. M. F.</creator><creator>Khatab, H.</creator><creator>Mostafa, T.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200710</creationdate><title>Mast cells in testicular biopsies of azoospermic men</title><author>Roaiah, M. M. F. ; Khatab, H. ; Mostafa, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4843-14ca9d4decf02e2e13ccca845d57afb778d97fa6990608019fb80a2a15c75f763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Azoospermia</topic><topic>Azoospermia - pathology</topic><topic>Azoospermia - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Birth control</topic><topic>Case-Control Studies</topic><topic>Cell Count</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>male infertility</topic><topic>mast cells</topic><topic>Mast Cells - pathology</topic><topic>Mast Cells - physiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Spermatogenesis - physiology</topic><topic>Sterility. Assisted procreation</topic><topic>testis</topic><topic>Testis - pathology</topic><topic>Testis - physiopathology</topic><topic>testis biopsy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roaiah, M. M. F.</creatorcontrib><creatorcontrib>Khatab, H.</creatorcontrib><creatorcontrib>Mostafa, T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roaiah, M. M. F.</au><au>Khatab, H.</au><au>Mostafa, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mast cells in testicular biopsies of azoospermic men</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2007-10</date><risdate>2007</risdate><volume>39</volume><issue>5</issue><spage>185</spage><epage>189</epage><pages>185-189</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><coden>ANDRDQ</coden><abstract>Summary
This work aimed at identifying mast cells in testicular biopsies from 10 normal fertile controls, 20 patients with obstructive azoospermia and 70 patients with nonobstructive azoospermia. The biopsies were stained with haematoxylin and eosin stain for tubular‐modified Johnson score and with toluidine blue stain for mast cells. Two populations of mast cells, peritubular and interstitial, were demonstrated in all sections with varied counts. Testicular sections with Sertoli cell only and spermatogenic arrest patterns demonstrated a significant increase in both peritubular and interstitial mast cells compared with other groups, whereas obstructive azoospermia demonstrated a nonsignificant increase compared with the controls. Mast cell count was significantly correlated negatively with Johnson score for both peritubular (P = 0.001) and interstitial (P = 0.001) populations. Whether these results could be a cause or an effect, a special role might be assigned to mast cells in the pathogenesis of disturbed spermatogenesis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17714217</pmid><doi>10.1111/j.1439-0272.2007.00793.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Azoospermia Azoospermia - pathology Azoospermia - physiopathology Biological and medical sciences Biopsy Birth control Case-Control Studies Cell Count Gynecology. Andrology. Obstetrics Humans Male Male genital diseases male infertility mast cells Mast Cells - pathology Mast Cells - physiology Medical sciences Middle Aged Spermatogenesis - physiology Sterility. Assisted procreation testis Testis - pathology Testis - physiopathology testis biopsy |
| title | Mast cells in testicular biopsies of azoospermic men |
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