Indole-3-Carbinol Selectively Uncouples Expression and Activity of Estrogen Receptor Subtypes in Human Breast Cancer Cells

Estrogen-responsive breast cancer cells, such as MCF7 and T47D cells, express both estrogen receptor (ER)-α (ERα) and ERβ. Indole-3-carbinol (I3C) strongly down-regulated ERα protein and transcript levels, without altering the level of ERβ protein, in both cell lines. In cells transfected with the E...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2006-12, Vol.20 (12), p.3070-3082
Hauptverfasser:	Sundar, Shyam N, Kerekatte, Vaishali, Equinozio, Caterina N, Doan, Victor B, Bjeldanes, Leonard F, Firestone, Gary L
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticarcinogenic Agents - pharmacology Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Proliferation - drug effects Down-Regulation Estrogen Receptor alpha - antagonists & inhibitors Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen Receptor beta - antagonists & inhibitors Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism Estrogens - pharmacology Humans Indoles - pharmacology Promoter Regions, Genetic Receptors, Progesterone - metabolism Transcription Factor AP-1 - agonists Transcription Factor AP-1 - metabolism Transcription, Genetic - drug effects Tumor Cells, Cultured
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