The human pyramidal syndrome Redux
Experimental studies in nonhuman primates have questioned the selectivity of pyramidal tract damage in giving rise to the classical pyramidal syndrome in humans, characterized by permanent spastic hemiplegia (PSH). According to this view, concomitant injury of extrapyramidal pathways is necessary fo...
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| Veröffentlicht in: | Neuroreport 2007-09, Vol.18 (14), p.1417-1421 |
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| container_title | Neuroreport |
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| creator | Tovar-Moll, Fernanda Moll, Jorge Bramati, Ivanei Edson de Souza, Andrea Silveira Andreiuolo, Pedro Angelo de Oliveira-Souza, Ricardo |
| description | Experimental studies in nonhuman primates have questioned the selectivity of pyramidal tract damage in giving rise to the classical pyramidal syndrome in humans, characterized by permanent spastic hemiplegia (PSH). According to this view, concomitant injury of extrapyramidal pathways is necessary for the development of both hemiplegia and spasticity. In this study we used conventional magnetic resonance imaging and diffusion tensor imaging tractography to characterize the anatomical correlates of PSH in a patient with a rare and discrete unilateral lesion of the medullary pyramid. Our findings support the hypothesis that damage confined to the medullary pyramid/pyramidal tract is sufficient to produce PSH. In contrast to nonhuman primates, the human ‘pyramidal’ and ‘pyramid’ syndromes are equivalent clinico-anatomic concepts. |
| doi_str_mv | 10.1097/WNR.0b013e3282e9a509 |
| format | Article |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Biological and medical sciences Diffusion Magnetic Resonance Imaging - methods Female Fundamental and applied biological sciences. Psychology Hemiplegia - pathology Hemiplegia - physiopathology Humans Imaging, Three-Dimensional Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Neuropsychological Tests Primates Pyramidal Tracts - pathology Pyramidal Tracts - physiopathology Syndrome Vertebrates: nervous system and sense organs |
| title | The human pyramidal syndrome Redux |
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