Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes

Melanosome transport in melanocytes is a model system for the study of cytoskeletal regulation of intracellular transport. Melanophilin (Mlph) is a Rab27a- and myosin Va (MyoVa)-binding protein that regulates this process. Using yeast two-hybrid screening, we identified MT plus-end binding protein (...

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Veröffentlicht in:	Journal of cell science 2007-09, Vol.120 (17), p.3111-3122
Hauptverfasser:	Hume, Alistair N, Ushakov, Dmitry S, Tarafder, Abul K, Ferenczi, Michael A, Seabra, Miguel C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Sequence Animals Binding Sites Biological Transport - physiology Humans Melanocytes - cytology Melanocytes - metabolism Melanosomes - metabolism Melanosomes - ultrastructure Mice Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Molecular Sequence Data Myosin Heavy Chains - genetics Myosin Heavy Chains - metabolism Myosin Type V - genetics Myosin Type V - metabolism Protein Binding rab GTP-Binding Proteins - genetics rab GTP-Binding Proteins - metabolism rab27 GTP-Binding Proteins RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Sequence Alignment Two-Hybrid System Techniques
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