Enhanced Levels of Oxidized Low-Density Lipoprotein Prime Monocytes to Cytokine Overproduction via Upregulation of CD14 and Toll-Like Receptor 4 in Unstable Angina

OBJECTIVES—The purpose of this study was to establish whether oxidized low-density lipoprotein (oxLDL) contributes to cytokine overproduction via upregulation of CD14 and toll-like receptor-4 (TLR-4) expression on circulating monocytes of unstable angina (UA) patients. METHODS AND RESULTS—Expression...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2007-09, Vol.27 (9), p.1991-1997
Hauptverfasser:	Pasini, A Fratta, Anselmi, M, Garbin, U, Franchi, E, Stranieri, C, Nava, M C, Boccioletti, V, Vassanelli, C, Cominacini, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angina, Unstable - blood Angina, Unstable - metabolism Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood. Blood coagulation. Reticuloendothelial system Cardiology. Vascular system Coronary heart disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Heart Humans Interleukin-1beta - metabolism Interleukin-6 - metabolism Lipopolysaccharide Receptors - metabolism Lipoproteins, LDL - physiology Male Medical sciences Middle Aged Monocytes - metabolism Pharmacology. Drug treatments Toll-Like Receptor 4 - metabolism Up-Regulation
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