Basal ganglia oscillations and pathophysiology of movement disorders
Low frequency rest tremor is one of the cardinal signs of Parkinson's disease and some of its animal models. Current physiological studies and models of the basal ganglia differ as to which aspects of neuronal activity are crucial to the pathophysiology of Parkinson's disease. There is evi...
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| Veröffentlicht in: | Current opinion in neurobiology 2006-12, Vol.16 (6), p.629-637 |
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| creator | Rivlin-Etzion, Michal Marmor, Odeya Heimer, Gali Raz, Aeyal Nini, Asaph Bergman, Hagai |
| description | Low frequency rest tremor is one of the cardinal signs of Parkinson's disease and some of its animal models. Current physiological studies and models of the basal ganglia differ as to which aspects of neuronal activity are crucial to the pathophysiology of Parkinson's disease. There is evidence that neural oscillations and synchronization play a central role in the generation of the disease. However, parkinsonian tremor is not strictly correlated with the synchronous oscillations in the basal ganglia networks. Rather, abnormal basal ganglia output enforces abnormal thalamo-cortical processing leading to akinesia, the main negative symptom of Parkinson's disease. Parkinsonian tremor has probably evolved as a downstream compensatory mechanism. |
| doi_str_mv | 10.1016/j.conb.2006.10.002 |
| format | Article |
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Current physiological studies and models of the basal ganglia differ as to which aspects of neuronal activity are crucial to the pathophysiology of Parkinson's disease. There is evidence that neural oscillations and synchronization play a central role in the generation of the disease. However, parkinsonian tremor is not strictly correlated with the synchronous oscillations in the basal ganglia networks. Rather, abnormal basal ganglia output enforces abnormal thalamo-cortical processing leading to akinesia, the main negative symptom of Parkinson's disease. Parkinsonian tremor has probably evolved as a downstream compensatory mechanism.</description><identifier>ISSN: 0959-4388</identifier><identifier>EISSN: 1873-6882</identifier><identifier>DOI: 10.1016/j.conb.2006.10.002</identifier><identifier>PMID: 17084615</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Basal Ganglia - metabolism ; Basal Ganglia - physiopathology ; Biological Clocks - physiology ; Dopamine - deficiency ; Frontal Lobe - physiopathology ; Humans ; Models, Neurological ; Nerve Net - metabolism ; Nerve Net - physiopathology ; Neural Pathways - metabolism ; Neural Pathways - physiopathology ; Parkinson Disease - metabolism ; Parkinson Disease - physiopathology ; Thalamus - physiopathology</subject><ispartof>Current opinion in neurobiology, 2006-12, Vol.16 (6), p.629-637</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-b677fd2bb2e123b894db533de52e29ed3e0e667e0476439fffa8f9bd3462b2b73</citedby><cites>FETCH-LOGICAL-c385t-b677fd2bb2e123b894db533de52e29ed3e0e667e0476439fffa8f9bd3462b2b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0959438806001401$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17084615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rivlin-Etzion, Michal</creatorcontrib><creatorcontrib>Marmor, Odeya</creatorcontrib><creatorcontrib>Heimer, Gali</creatorcontrib><creatorcontrib>Raz, Aeyal</creatorcontrib><creatorcontrib>Nini, Asaph</creatorcontrib><creatorcontrib>Bergman, Hagai</creatorcontrib><title>Basal ganglia oscillations and pathophysiology of movement disorders</title><title>Current opinion in neurobiology</title><addtitle>Curr Opin Neurobiol</addtitle><description>Low frequency rest tremor is one of the cardinal signs of Parkinson's disease and some of its animal models. 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| ispartof | Current opinion in neurobiology, 2006-12, Vol.16 (6), p.629-637 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Basal Ganglia - metabolism Basal Ganglia - physiopathology Biological Clocks - physiology Dopamine - deficiency Frontal Lobe - physiopathology Humans Models, Neurological Nerve Net - metabolism Nerve Net - physiopathology Neural Pathways - metabolism Neural Pathways - physiopathology Parkinson Disease - metabolism Parkinson Disease - physiopathology Thalamus - physiopathology |
| title | Basal ganglia oscillations and pathophysiology of movement disorders |
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