Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass
Low bone mineral density is frequently seen in COPD patients. Advanced COPD, low BMI and muscle depletion are risk factors for developing low bone mineral density (BMD). Low bone mineral density is seen in 75% of the GOLD stage IV patients. We set out to investigate the prevalence of low bone minera...
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| Veröffentlicht in: | Osteoporosis international 2007-09, Vol.18 (9), p.1197-1202 |
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| description | Low bone mineral density is frequently seen in COPD patients. Advanced COPD, low BMI and muscle depletion are risk factors for developing low bone mineral density (BMD). Low bone mineral density is seen in 75% of the GOLD stage IV patients.
We set out to investigate the prevalence of low bone mineral density (BMD) in chronic obstructive pulmonary disease (COPD) as well as the predictors of abnormal bone mineral density.
A cross-sectional design was used to evaluate 115 subjects with COPD (GOLD stages II-IV). Bone mineral density (BMD) was measured using an ultrasound densitometer. The forced expiratory volume in 1 s (FEV(1)) was assessed and fat-free mass was measured using bioelectrical impedance analysis. Chi-square tests and logistic regression were used for analysis.
The prevalence of a T-score < -1.0 SD and > -2.5 SD was 28.6% in GOLD stage II, 40.3% in GOLD stage III and 57.1% in GOLD stage IV. The prevalence of a T-score |
| doi_str_mv | 10.1007/s00198-007-0355-7 |
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We set out to investigate the prevalence of low bone mineral density (BMD) in chronic obstructive pulmonary disease (COPD) as well as the predictors of abnormal bone mineral density.
A cross-sectional design was used to evaluate 115 subjects with COPD (GOLD stages II-IV). Bone mineral density (BMD) was measured using an ultrasound densitometer. The forced expiratory volume in 1 s (FEV(1)) was assessed and fat-free mass was measured using bioelectrical impedance analysis. Chi-square tests and logistic regression were used for analysis.
The prevalence of a T-score < -1.0 SD and > -2.5 SD was 28.6% in GOLD stage II, 40.3% in GOLD stage III and 57.1% in GOLD stage IV. The prevalence of a T-score <or=-2.5 SD was 0% in GOLD stage II, 9.6% in GOLD stage III and 17.9% in GOLD stage IV. In a logistic model FFM, BMI and FEV(1) were significant predictors of abnormal bone mineral density. Patients in GOLD stage IV have a 7.6 times greater risk of abnormal bone mineral density than patients in GOLD stage II.
Low bone mineral density is frequently present in COPD patients. Low FFM, BMI and FEV(1) are risk factors for developing a low T-score. A low FFM or BMI in GOLD stage IV strongly suggests loss of BMD and warrants further examination.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-007-0355-7</identifier><identifier>PMID: 17347789</identifier><language>eng</language><publisher>London: Springer</publisher><subject>Biological and medical sciences ; Body fat ; Body Mass Index ; Bone density ; Bone Density - physiology ; Chi-Square Distribution ; Chronic obstructive pulmonary disease ; Chronic obstructive pulmonary disease, asthma ; Correlation analysis ; Cross-Sectional Studies ; Diseases of the osteoarticular system ; Female ; Forced Expiratory Volume ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Osteoarticular system. Muscles ; Osteoporosis ; Osteoporosis - etiology ; Osteoporosis - physiopathology ; Osteoporosis. Osteomalacia. Paget disease ; Pneumology ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Risk factors ; Thinness - physiopathology</subject><ispartof>Osteoporosis international, 2007-09, Vol.18 (9), p.1197-1202</ispartof><rights>2007 INIST-CNRS</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-2fe15f614b8d5cf6941398c6a3b29590db652911950458b43d8bc89e426961153</citedby><cites>FETCH-LOGICAL-c465t-2fe15f614b8d5cf6941398c6a3b29590db652911950458b43d8bc89e426961153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18976397$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17347789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VRIEZE, A</creatorcontrib><creatorcontrib>DE GREEF, M. H. G</creatorcontrib><creatorcontrib>WYKSTRA, P. J</creatorcontrib><creatorcontrib>WEMPE, J. B</creatorcontrib><title>Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><description>Low bone mineral density is frequently seen in COPD patients. Advanced COPD, low BMI and muscle depletion are risk factors for developing low bone mineral density (BMD). Low bone mineral density is seen in 75% of the GOLD stage IV patients.
We set out to investigate the prevalence of low bone mineral density (BMD) in chronic obstructive pulmonary disease (COPD) as well as the predictors of abnormal bone mineral density.
A cross-sectional design was used to evaluate 115 subjects with COPD (GOLD stages II-IV). Bone mineral density (BMD) was measured using an ultrasound densitometer. The forced expiratory volume in 1 s (FEV(1)) was assessed and fat-free mass was measured using bioelectrical impedance analysis. Chi-square tests and logistic regression were used for analysis.
The prevalence of a T-score < -1.0 SD and > -2.5 SD was 28.6% in GOLD stage II, 40.3% in GOLD stage III and 57.1% in GOLD stage IV. The prevalence of a T-score <or=-2.5 SD was 0% in GOLD stage II, 9.6% in GOLD stage III and 17.9% in GOLD stage IV. In a logistic model FFM, BMI and FEV(1) were significant predictors of abnormal bone mineral density. Patients in GOLD stage IV have a 7.6 times greater risk of abnormal bone mineral density than patients in GOLD stage II.
Low bone mineral density is frequently present in COPD patients. Low FFM, BMI and FEV(1) are risk factors for developing a low T-score. A low FFM or BMI in GOLD stage IV strongly suggests loss of BMD and warrants further examination.</description><subject>Biological and medical sciences</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>Bone density</subject><subject>Bone Density - physiology</subject><subject>Chi-Square Distribution</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Correlation analysis</subject><subject>Cross-Sectional Studies</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osteoarticular system. Muscles</subject><subject>Osteoporosis</subject><subject>Osteoporosis - etiology</subject><subject>Osteoporosis - physiopathology</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Pneumology</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Risk factors</subject><subject>Thinness - physiopathology</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkUuLFDEUhYMoTjv6A9xIEHRlNKm8l9I-oWFcKLgLqdTNWEN10iYpmvn3pumGAVf3Lr5z7uMg9JLR94xS_aFSyqwhvSWUS0n0I7RhgnMyWCUfow21XBMr2O8r9KzWO9pBa_VTdMU0F1obu0GHXT7iMSfA-zlB8QueINW53eM54e3Nj0_44NsMqVVcYPENJtwyPuZSAS9rusVxTaHNOb3DS3c6wnz7p2Gfpu4TCvjaBdE3Egv0Eb7W5-hJ9EuFF5d6jX59-fxz-43sbr5-337ckSCUbGSIwGRUTIxmkiGqfgW3JijPx8FKS6dRycEyZiUV0oyCT2YMxoIYlFWMSX6N3p59DyX_XaE2t59rgGXxCfJanTLMUiNUB1__B97ltaS-mxuYMQNVmneInaFQcq0FojuUee_LvWPUnbJw5yzcqT1l4XTXvLoYr-MepgfF5fkdeHMBfA1-icWnMNcHzlituNX8HwR_kEI</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>VRIEZE, A</creator><creator>DE GREEF, M. 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B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-2fe15f614b8d5cf6941398c6a3b29590db652911950458b43d8bc89e426961153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>Bone density</topic><topic>Bone Density - physiology</topic><topic>Chi-Square Distribution</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Correlation analysis</topic><topic>Cross-Sectional Studies</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osteoarticular system. Muscles</topic><topic>Osteoporosis</topic><topic>Osteoporosis - etiology</topic><topic>Osteoporosis - physiopathology</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Pneumology</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Risk factors</topic><topic>Thinness - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VRIEZE, A</creatorcontrib><creatorcontrib>DE GREEF, M. H. G</creatorcontrib><creatorcontrib>WYKSTRA, P. J</creatorcontrib><creatorcontrib>WEMPE, J. 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H. G</au><au>WYKSTRA, P. J</au><au>WEMPE, J. B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass</atitle><jtitle>Osteoporosis international</jtitle><addtitle>Osteoporos Int</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>18</volume><issue>9</issue><spage>1197</spage><epage>1202</epage><pages>1197-1202</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Low bone mineral density is frequently seen in COPD patients. Advanced COPD, low BMI and muscle depletion are risk factors for developing low bone mineral density (BMD). Low bone mineral density is seen in 75% of the GOLD stage IV patients.
We set out to investigate the prevalence of low bone mineral density (BMD) in chronic obstructive pulmonary disease (COPD) as well as the predictors of abnormal bone mineral density.
A cross-sectional design was used to evaluate 115 subjects with COPD (GOLD stages II-IV). Bone mineral density (BMD) was measured using an ultrasound densitometer. The forced expiratory volume in 1 s (FEV(1)) was assessed and fat-free mass was measured using bioelectrical impedance analysis. Chi-square tests and logistic regression were used for analysis.
The prevalence of a T-score < -1.0 SD and > -2.5 SD was 28.6% in GOLD stage II, 40.3% in GOLD stage III and 57.1% in GOLD stage IV. The prevalence of a T-score <or=-2.5 SD was 0% in GOLD stage II, 9.6% in GOLD stage III and 17.9% in GOLD stage IV. In a logistic model FFM, BMI and FEV(1) were significant predictors of abnormal bone mineral density. Patients in GOLD stage IV have a 7.6 times greater risk of abnormal bone mineral density than patients in GOLD stage II.
Low bone mineral density is frequently present in COPD patients. Low FFM, BMI and FEV(1) are risk factors for developing a low T-score. A low FFM or BMI in GOLD stage IV strongly suggests loss of BMD and warrants further examination.</abstract><cop>London</cop><pub>Springer</pub><pmid>17347789</pmid><doi>10.1007/s00198-007-0355-7</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Body fat Body Mass Index Bone density Bone Density - physiology Chi-Square Distribution Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma Correlation analysis Cross-Sectional Studies Diseases of the osteoarticular system Female Forced Expiratory Volume Humans Investigative techniques, diagnostic techniques (general aspects) Logistic Models Male Medical sciences Middle Aged Osteoarticular system. Muscles Osteoporosis Osteoporosis - etiology Osteoporosis - physiopathology Osteoporosis. Osteomalacia. Paget disease Pneumology Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - physiopathology Radiodiagnosis. Nmr imagery. Nmr spectrometry Risk factors Thinness - physiopathology |
| title | Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass |
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