Effects of BMP-2 and pulsed electromagnetic field (PEMF) on rat primary osteoblastic cell proliferation and gene expression

Bone morphogenetic proteins (BMPs) strongly promote osteoblast differentiation. Pulsed electromagnetic fields (PEMFs) promote fracture healing in non‐union fractures. In this study, we hypothesized that a combined BMP‐2 and PEMF stimulation would augment bone formation to a greater degree than treat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of orthopaedic research 2007-09, Vol.25 (9), p.1213-1220
Hauptverfasser:	Selvamurugan, Nagarajan, Kwok, Sukyee, Vasilov, Anatoliy, Jefcoat, Stephen C., Partridge, Nicola C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Animals Animals, Newborn Biomarkers - metabolism BMP-2 bone formation Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - pharmacology Cell Proliferation - drug effects Cell Proliferation - radiation effects Cells, Cultured Collagen Type I - genetics Collagen Type I - metabolism Dose-Response Relationship, Drug Electromagnetic Fields Gene Expression - drug effects Gene Expression - radiation effects osteoblast Osteoblasts - drug effects Osteoblasts - pathology Osteoblasts - radiation effects Osteocalcin - genetics Osteocalcin - metabolism PEMF Rats RNA, Messenger - metabolism Skull - cytology Transforming Growth Factor beta - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!