Gatifloxacin acutely stimulates insulin secretion and chronically suppresses insulin biosynthesis

Gatifloxacin can cause both hypoglycemia and hyperglycemia in both diabetic and non-diabetic patients. Gatifloxacin recently has been reported to stimulate insulin secretion by inhibition of ATP-sensitive K + (K ATP) channels in pancreatic β-cells. Gatifloxacin-induced hypoglycemia is associated wit...

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Veröffentlicht in:	European journal of pharmacology 2006-12, Vol.553 (1), p.67-72
Hauptverfasser:	Yamada, Chizumi, Nagashima, Kazuaki, Takahashi, Akira, Ueno, Hiroyuki, Kawasaki, Yukiko, Yamada, Yuichiro, Seino, Yutaka, Inagaki, Nobuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - pharmacology Biological and medical sciences Blood Glucose - metabolism Cell Line, Tumor Cell Separation Fluoroquinolones - pharmacology Gatifloxacin Glyburide - pharmacology Hyperglycemia Hypoglycemia Hypoglycemic Agents - pharmacology In Vitro Techniques Insulin - biosynthesis Insulin - metabolism Insulin Antagonists Insulin Secretion Insulinoma - metabolism Islet insulin content Islets of Langerhans - drug effects Islets of Langerhans - metabolism K ATP (ATP-sensitive K +) channel Male Medical sciences Mice Mice, Inbred C57BL Pancreatic Neoplasms - metabolism Pharmacology. Drug treatments Quinolones - pharmacology RNA, Messenger - biosynthesis
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