Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides

New chemistry was developed to introduce a nitrogen substituent at the C12 position of ketolide template. This led to syntheses of novel C11, C12-cyclic urea analogues of ketolides that exhibited potent in vitro antibacterial activity. C11, C12-cyclic urea analogues of ketolides were designed and sy...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-09, Vol.17 (18), p.5013-5018
Hauptverfasser:	Kaneko, Takushi, McMillen, William, Lynch, Meghan Keaney
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cyclic urea Haemophillus influenzae Ketene acetal Ketolide Ketolides - chemical synthesis Ketolides - chemistry Ketolides - pharmacology Macrolide Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Streptococcus pneumoniae Streptococcus pyogenes Streptococcus pyogenes - drug effects Telithromycin Urea - chemistry
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