Nerve growth factor is critical for cardiac sensory innervation and rescues neuropathy in diabetic hearts

Molecular mechanisms regulating the cardiac sensory nervous system remain poorly understood. Cardiac sensory nerve impairment causes silent myocardial ischemia, a main cause of sudden death in diabetes mellitus (DM). The present study focused on the roles of nerve growth factor (NGF) in the regulati...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2006-11, Vol.114 (22), p.2351-2363
Hauptverfasser:	IEDA, Masaki, KANAZAWA, Hideaki, MAKINO, Shinji, SANO, Motoaki, FUKUDA, Keiichi, IEDA, Yasuyo, KIMURA, Kensuke, MATSUMURA, Keisuke, TOMITA, Yuichi, YAGI, Takashi, ONIZUKA, Takeshi, SHIMOJI, Kenichiro, OGAWA, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways - physiology Afferent Pathways - physiopathology Animals Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Crosses, Genetic Diabetes Mellitus, Experimental - genetics Diabetic Neuropathies - genetics Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Fundamental and applied biological sciences. Psychology Gene Transfer Techniques Heart Conduction System - physiology Heart Conduction System - physiopathology Hormones. Endocrine system Male Medical sciences Mice Mice, Knockout Mice, Transgenic Myosin Heavy Chains - genetics Nerve Growth Factor - deficiency Nerve Growth Factor - genetics Pharmacology. Drug treatments Promoter Regions, Genetic Rats Vertebrates: cardiovascular system
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