Challenges and obstacles of ocular pharmacokinetics and drug delivery
Modern biological research has produced increasing number of promising therapeutic possibilities for medical treatment. These include for example growth factors, monoclonal antibodies, gene knockdown methods, gene therapy, surgical transplantations and tissue engineering. Ocular application of these...
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| Veröffentlicht in: | Advanced drug delivery reviews 2006-11, Vol.58 (11), p.1131-1135 |
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| container_title | Advanced drug delivery reviews |
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| creator | Urtti, Arto |
| description | Modern biological research has produced increasing number of promising therapeutic possibilities for medical treatment. These include for example growth factors, monoclonal antibodies, gene knockdown methods, gene therapy, surgical transplantations and tissue engineering. Ocular application of these possibilities involves drug delivery in many forms. Ocular drug delivery is hampered by the barriers protecting the eye. This review presents an overview of the essential factors in ocular pharmacokinetics and selected pharmacological future challenges in ophthalmology. |
| doi_str_mv | 10.1016/j.addr.2006.07.027 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Advanced drug delivery reviews, 2006-11, Vol.58 (11), p.1131-1135 |
| issn | 0169-409X 1872-8294 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Blood-Aqueous Barrier - metabolism Drug delivery Drug Delivery Systems Epithelial barriers Eye Eye - metabolism Eye Diseases - drug therapy Humans Pharmaceutical Preparations - administration & dosage Pharmacokinetics Posterior segment |
| title | Challenges and obstacles of ocular pharmacokinetics and drug delivery |
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