Early detection and monitoring of cartilage alteration in the experimental meniscectomised guinea pig model of osteoarthritis by 99mTc-NTP 15-5 scintigraphy

This study in the meniscectomised guinea pig aimed to demonstrate that the radiotracer (99m)Tc-NTP 15-5 would have pathophysiological validity for in vivo osteoarthritis imaging. The specificity of (99m)Tc-NTP 15-5 for cartilage was determined in healthy animals (n = 13), by tissue radioactivity cou...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2007-08, Vol.34 (8), p.1280-1290
Hauptverfasser:	Miot-Noirault, Elisabeth, Vidal, Aurélien, Pastoureau, Philippe, Bonafous, Jacques, Chomel, Agnès, Sarry, Laurent, Audin, Laurent, Madelmont, Jean-Claude, Moins, Nicole
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Animals Arthritis Autoradiography Biomedical materials Cartilage Cartilage - diagnostic imaging Cartilage - pathology Cartilage diseases Cartilage Diseases - diagnostic imaging Cartilage Diseases - pathology Disease Models, Animal Early Diagnosis Guinea Pigs Heterocyclic Compounds, 1-Ring In vivo methods and tests Joints (anatomy) Joints - diagnostic imaging Joints - pathology Knee Male Medical imaging Menisci, Tibial - pathology Models, Chemical Nuclear medicine Osteoarthritis Osteoarthritis - diagnosis Osteoarthritis - diagnostic imaging Quaternary Ammonium Compounds Radioactive tracers Radioactivity Radionuclide Imaging - methods Rodents Scintigraphy Technetium Time Factors
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